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    OpenPayerBilling CodesUrethra and Bladder Transurethral Surgical ProceduresCPT cpt-52250-cystoscopic-intravesical-radioactive-therapy-for-bladder-cancer
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    CPT 52250: Cystoscopy with Intravesical Radioisotope Therapy

    Medicare pays $215 on average nationally for this procedure.

    CPT code 52250 describes cystoscopic inspection of the urethra, prostatic urethra (in men), bladder interior, and ureteric orifices with placement of an intravesical radioactive substance to treat bladder cancer; the procedure is a cystoscopic therapeutic intervention that may include fulguration or biopsy of suspicious lesions. Service type: cystoscopic therapeutic procedure with intravesical radioisotope instillation. Typical site of service: ambulatory surgery center or hospital outpatient department where cystoscopy and intravesical oncologic therapy are performed.

    For related coverage guidance, see recent payer policy updates: Abortion Services, Prolonged Services for Labor Management, Prolonged Services for Labor Management.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 72-year-old male with a history of high-grade non–muscle-invasive bladder cancer presents for intravesical radioactive isotope therapy delivered via cystoscope. The patient arrives to an ambulatory surgical center after preoperative evaluation including urinalysis and medication reconciliation. Under monitored anesthesia care or general anesthesia provided by the anesthesiologist, the urologist performs a diagnostic cystoscopy using a rigid or flexible cystoscope passed through the urethra to inspect the urethra, prostatic urethra, bladder interior, and ureteric orifices. After visual inspection, the provider instills a radioactive therapeutic agent into the bladder through the cystoscope delivery system to treat localized tumor burden; the provider may also fulgurate suspicious lesions or obtain cold cup or biopsy samples for pathology if indicated. Hemostasis is confirmed, the bladder is irrigated, and the patient is recovered in the PACU with voiding instructions and follow-up arranged with the treating urologist.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    52000Cystourethroscopy, with or without collection of specimen(s) by brushing or washing, with or without culture(s)Often used for diagnostic cystoscopy performed without therapeutic instillation; may be billed when only inspection and washings are done.
    52204Cystourethroscopy, with biopsy, single or multiple, cold; without fulgurationBilled when cystoscopic biopsy specimens are obtained without fulguration during the same session.
    52234Cystourethroscopy, with fulguration (including cryosurgery or laser); 1 or more lesionsBilled when lesions are ablated by fulguration or laser in addition to diagnostic cystoscopy.
    51720Cystourethroscopy with insertion of indwelling ureteral stentPerformed if ureteral orifice involvement necessitates stent placement during the same episode.
    99024Postoperative follow-up visit, postoperative period, during global periodUsed for routine postoperative visits during the global period after the procedure when applicable.

    Related Modifiers

    13 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Showing 1–10 of 13

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207K00000X
    208000000X
    207L00000X
    363L00000X
    224L00000X
    163WP0000X
    2471C1106X
    320600000X

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    C61Malignant neoplasm of prostate
    C67.9Malignant neoplasm of bladder, unspecified
    D09.0Carcinoma in situ of bladder
    N12Tubulo-interstitial nephritis, not specified as acute or chronic
    N13.6Pyonephrosis
    N20.0Calculus of kidney
    N20.1Calculus of ureter
    N20.2Calculus of kidney with calculus of ureter
    N30.10Interstitial cystitis (chronic) without hematuria
    N30.90Cystitis, unspecified without hematuria

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Obstetrics/Gynecology1 / 2

    10 rows

    PolicyPayerEffective Date
    Abortion ServicesNew Mexico Health Care Authority2027-01-01
    Prolonged Services for Labor ManagementPremera Bluecross2027-01-01
    Prolonged Services for Labor ManagementPremera Bluecross2027-01-01
    Maternal Serum Testing for Prediction of Adverse Obstetric OutcomesPremera Bluecross2026-10-01
    Maternal Serum Testing for Prediction of Adverse Obstetric OutcomesPremera Bluecross2026-10-01
    Maternal Serum Testing for Prediction of Adverse Obstetric OutcomesBlue Cross Blue Shield - Massachusetts2026-10-01
    Cervical Cancer ScreeningOscar Health2026-10-01
    Prenatal Testing for Fetal AneuploidyOscar Health2026-10-01
    Diagnosis of VaginitisOscar Health2026-10-01
    Prenatal Screening (Nongenetic)Oscar Health2026-10-01

    Related Codes

    CPT-52204-CYSTOURETHROSCOPY-WITH-BIOPSY

    CPT 52204: Cystourethroscopy with Biopsy

    CPT-52214-TRANSURETHRAL-BLADDER-URETHRAL-TISSUE-DESTRUCTION

    CPT 52214: Endoscopic Destruction of Bladder/Urethral Tissue

    CPT-52224-CYSTOSCOPY-LESION-DESTRUCTION-MINOR

    CPT 52224: Cystoscopy with Destruction of Minor Bladder Lesion

    CPT-52234-CYSTOSCOPIC-DESTRUCTION-SMALL-BLADDER-LESION

    CPT 52234: Cystoscopy with Destruction of Small Bladder Lesion

    CPT-52235-CYSTOSCOPIC-DESTRUCTION-MEDIUM-BLADDER-LESION-2-5CM

    CPT 52235: Cystoscopy with Fulguration of Medium Bladder Lesion

    CPT-52240-CYSTOSCOPY-LESION-FULGURATION-ABLATION-GREATER-THAN-5CM

    CPT 52240: Cystoscopy with Destruction of Bladder Lesion (>5.0 cm)

    CPT-52260-DIAGNOSTIC-CYSTOSCOPY-INTERSTITIAL-CYSTITIS-EVALUATION

    CPT 52260: Cystoscopic Inspection Under Anesthesia for Interstitial Cystitis

    CPT-52265-DIAGNOSTIC-CYSTOSCOPY-INTERSTITIAL-CYSTITIS-EVALUATION

    CPT 52265: Diagnostic Cystoscopy for Interstitial Cystitis

    CPT-52270-CYSTOSCOPIC-URETHROTOMY-INTERNAL-URETHRAL-STRICTURE

    CPT 52270: Cystoscopy with Incision of Internal Urethral Stricture (Female)

    CPT-52275-CYSTOSCOPY-INTERNAL-URETHROTOMY-STRICTURE-INCISION

    CPT 52275: Cystoscopy with Internal Urethrotomy

    Showing 1–10 of 26

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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