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    v1.0.30
    OpenPayerBilling CodesOther Renal Introduction (Injection/Change/Removal) ProceduresCPT cpt-50390-renal-cyst-aspiration-sclerotherapy
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    CPT 50390: Renal Cyst Aspiration with Sclerotherapy

    Medicare pays $82 on average nationally for this procedure.

    CPT code 50390 describes aspiration or drainage of a renal cyst, including injection of a sclerosing agent (for example, acetic acid or ethanol) to collapse the cyst when it causes symptoms; the service is a renal cyst aspiration/sclerotherapy procedure typically performed as a radiologic or interventional procedure in an outpatient radiology suite, ambulatory surgery center, or hospital procedure room.

    For related coverage guidance, see recent payer policy updates: Vafseo (vadadustat) for anemia in CKD on dialysis, Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family Plans, Kerendia (finerenone) — Coverage Criteria.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 55-year-old adult presenting with intermittent flank pain, urinary frequency, or visible hematuria. Imaging (renal ultrasound or CT) demonstrates a simple or symptomatic renal cyst causing discomfort or recurrent symptoms. The urologist or interventional radiologist schedules a percutaneous renal cyst aspiration with possible sclerotherapy. The procedure is performed under ultrasound or CT guidance in an outpatient procedure suite, ambulatory surgery center, or hospital radiology/interventional suite. After informed consent and local anesthesia with or without conscious sedation, the provider advances a needle into the cyst, aspirates fluid for diagnostic analysis, evacuates cyst contents, and often injects a sclerosing agent (for example, ethanol) to reduce recurrence. Post-procedure monitoring occurs for vital signs, bleeding, or pain; discharge instructions address activity restrictions and signs of complication. Documentation includes indication, imaging guidance used, amount and character of aspirated fluid, agent instilled (if any), sedation and anesthesia details, laterality, and any specimens sent for pathology or culture.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    10022Fine needle aspiration; with imaging guidanceMay be used if a diagnostic fine needle aspiration of renal cyst fluid is performed under imaging guidance prior to or during cyst management
    49405Catheter drainage, percutaneous, simple (e.g., for renal or perirenal abscess)Related percutaneous drainage codes when catheter placement is required for ongoing drainage rather than single aspiration
    76604Ultrasound, abdominal, real time with image documentation; limited or follow-upFrequently performed to localize and guide the aspiration and to document cyst size pre- and post-procedure
    77012CT guidance for needle placementUsed when CT guidance is employed for percutaneous needle localization during cyst aspiration or injection
    99144Moderate sedation services provided by the same physician performing the procedure (revised code depends on payer)Reported when the provider or qualified clinician administers and monitors conscious sedation during the procedure
    88305Level IV surgical pathology, gross and microscopic examinationUsed if aspirated fluid or tissue is sent for cytology or pathology evaluation

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    363L00000X
    207RC0000X
    207K00000X
    103TR0400X
    235500000X
    133VN1501X
    207T00000X
    251K00000X

    Related Payer Policy Updates

    Specialty: Nephrology1 / 3

    10 rows

    PolicyPayerEffective Date
    Vafseo (vadadustat) for anemia in CKD on dialysisCigna2026-08-15
    Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family PlansCigna2026-08-15
    Kerendia (finerenone) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-05
    Voyxact (sibeprenlimab-szsl) — Prior authorization / medical necessity for primary IgA nephropathyColorado Rocky Mountain Health Plans2026-08-01
    Oxlumo (lumasiran) and Rivfloza (nedosiran) — Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Korsuva (difelikefalin) — Medical Benefit Drug Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Complement Inhibitors - EmpaveliCigna2026-08-01
    Tolvaptan (Jynarque)Cigna2026-08-01
    Nephrology - Filspari (sparsentan) coverageCigna2026-08-01
    Rivfloza (nedosiran) prior authorization for PH1UnitedHealthcare2026-08-01

    Related Codes

    CPT-50391-THERAPEUTIC-INSTILLATION-RENAL-PELVIS-URETER

    CPT 50391: Intrarenal/Ureteral Therapeutic Agent Injection

    CPT-50396-URETERAL-NEPHROSTOMY-PYELOSTOMY-PRESSURE-MEASUREMENT

    CPT 50396: Ureteral/Nephrostomy Tube Pressure Measurement

    CPT-50436-PERCUTANEOUS-NEPHROSTOMY-TRACT-DILATION

    CPT 50436: Dilation of Percutaneous Nephrostomy Tract

    CPT-50437-PERCUTANEOUS-NEPHROSTOMY-TRACT-DILATION-AND-CREATION

    CPT 50437: Nephrostomy Tract Dilation and New Tract Creation

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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