CPT code 49405 denotes image-guided percutaneous catheter drainage used as first-line therapy to drain fluid collections in the abdomen and chest. This interventional procedure is clinically significant nationally because it provides a minimally invasive option to manage abscesses, effusions, and other fluid collections, often reducing need for open surgery and shortening recovery times. Payers commonly involved in covering this service include Aetna, Blue Cross Blue Shield, Cigna, UnitedHealthcare, and Medicare. Readers will find a concise explanation of the clinical intent and typical settings for the service, an overview of payer coverage considerations, and benchmarks and coding guidance relevant to billing and documentation. The publication also outlines common billing modifiers and service line implications for hospital inpatient, hospital outpatient, and ambulatory procedure center claims. Where specific input fields were not provided, such as associated taxonomies, ICD-10 diagnoses, and related codes, the document notes that data is not available in the input. This summary equips coding professionals, revenue cycle staff, and clinical leadership with the context needed to classify and submit claims for image-guided percutaneous catheter drainage under CPT code 49405.