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    v1.0.31
    OpenPayerBilling CodesEndoscopy Procedures on the RectumCPT cpt-45392-colonoscope-eus-guided-fna-biopsy
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    CPT 45392: Colonoscopy with Endoscopic Ultrasound–Guided FNA/Biopsy

    Medicare pays $271 on average nationally for this procedure.

    CPT code 45392 describes a diagnostic and interventional colonoscopy with endoscopic ultrasound–guided fine needle aspiration or biopsy, performed using a colonoscope to visualize the rectum, sigmoid, descending, transverse, ascending colon, cecum, and adjacent structures; service type: endoscopic ultrasound–guided tissue sampling; typical site of service: outpatient endoscopy suite or ambulatory surgical center where colonoscopic EUS with biopsy is performed.

    For related coverage guidance, see recent payer policy updates: Achalasia and Gastroesophageal Reflux Disease (GERD) - Minimally Invasive Procedures - Medical Policy, Esophageal Brush Biopsy, Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old patient with a history of iron-deficiency anemia and an occult positive fecal immunochemical test is referred for diagnostic evaluation. The gastroenterologist performs a colonoscopy using a flexible colonoscope to inspect the rectum, sigmoid, descending, transverse, ascending colon and cecum. During the exam the endoscopist identifies a subepithelial lesion in the ascending colon suspicious for a mass. Using the colonoscope’s working channel and endoscopic ultrasound guidance, the provider advances a fine needle to obtain targeted aspirate or core biopsy of the lesion for cytology and histology. The procedure is performed in an endoscopy suite with moderate sedation, with pathology specimens submitted to the laboratory. Typical workflow steps include pre-procedure consent and assessment, sedation and monitoring, colonoscopic inspection, endoscopic ultrasound–guided FNA/biopsy via the colonoscope, hemostasis as needed, recovery and post-procedure instructions, and submission of specimens to pathology for diagnostic evaluation. Payer interactions for authorization and claims use standard endoscopy documentation, operative note with lesion size/location, number of passes, specimen handling, and applicable modifier reporting.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    45378Colonoscopy, flexible, diagnostic, including collection of specimens by brushing or washing, when performed (separate procedure)Often performed as the initial diagnostic colonoscopy; may precede targeted EUS-guided biopsy if lesion identified.
    43237Upper GI endoscopy, flexible, transoral; with EUS-guided fine needle aspiration/biopsy(s) — this represents upper endoscopic EUS with FNAAnalogous EUS-guided FNA code for the upper GI tract; useful for cross-referencing EUS billing principles and modifiers.
    43238Upper gastrointestinal endoscopy with ultrasound guided transendoscopic biopsy(s) by FNA — with image documentationRelated for EUS-guided sampling technique coding conventions in endoscopy.
    43245Endoscopic ultrasound, diagnostic, with or without FNA — limited examples for upper GIProvides context on EUS procedural coding; colonoscopic EUS-guided FNA uses a specific colonoscopic code (45392).
    88312Surgical pathology, gross and microscopic examination, intermediate complexityRepresents common pathology CPT codes for cytology/histology processing of specimens obtained during FNA/biopsy.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RC0000X
    207L00000X
    207RA0000X
    364S00000X
    291U00000X
    364SP1700X
    2083A0100X
    208100000X

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Achalasia and Gastroesophageal Reflux Disease (GERD) - Minimally Invasive Procedures - Medical PolicyHealth-New-England2027-02-01
    Esophageal Brush Biopsycaresourcegeorgia2026-12-01
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Gastric Pacing/Gastric Electrical Stimulation (GES)Cigna2026-11-15
    Percutaneous Electrical Nerve Field Stimulation for Disorders of Gut-Brain Interactionpremerabluecrossofwashington2026-11-06
    Percutaneous electrical nerve field stimulation for disorders of gut-brain interactionpremerabluecrossofwashington2026-11-06
    Percutaneous Electrical Nerve Field Stimulation for Disorders of Gut-Brain Interactionpremerabluecrossofwashington2026-11-06
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Non-invasive Testing for Liver FibrosisModa Health2026-11-01
    Surgical Site of Care - Colonoscopy and Sigmoidoscopyregence2026-11-01

    Related Codes

    CPT-45300-PROCTOSIGMOIDOSCOPY-RIGID-DIAGNOSTIC

    CPT 45300: Diagnostic Proctosigmoidoscopy with Rigid Proctoscope

    CPT-45303-PROCTOSIGMOIDOSCOPY-WITH-STRICTURE-DILATION

    CPT 45303: Proctosigmoidoscopy with Stricture Dilation

    CPT-45305-PROCTOSIGMOIDOSCOPY-WITH-BIOPSY

    CPT 45305: Proctosigmoidoscopy with Biopsy

    CPT-45307-PROCTOSIGMOIDOSCOPY-LOWER-GI-ENDOSCOPY

    CPT 45307: Proctosigmoidoscopy of Rectum and Sigmoid Colon

    CPT-45308-PROCTOSIGMOIDOSCOPIC-LESION-REMOVAL

    CPT 45308: Proctosigmoidoscopy with Removal of Single Lesion

    CPT-45309-PROCTOSIGMOIDOSCOPY-SNARE-EXCISION-LESION

    CPT 45309: Proctosigmoidoscopy with Snare Polypectomy

    CPT-45315-PROCTOSIGMOIDOSCOPIC-POLYPECTOMY-MULTIPLE-LESIONS

    CPT 45315: Proctosigmoidoscopy with Multiple Lesion Removal

    CPT-45317-PROCTOSIGMOIDOSCOPY-WITH-HEMOSTASIS

    CPT 45317: Therapeutic Proctosigmoidoscopy for Hemorrhage Control

    CPT-45320-PROCTOSIGMOIDOSCOPIC-LESION-ABLATION

    CPT 45320: Proctosigmoidoscopic Ablation of Lesion

    CPT-45321-PROCTOSIGMOIDOSCOPIC-DECOMPRESSION-SIGMOID-VOLVULUS

    CPT 45321: Proctosigmoidoscopic Decompression of Volvulus

    Showing 1–10 of 39

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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