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    v1.0.28
    OpenPayerBilling CodesEndoscopy Procedures on the RectumCPT cpt-45388-colonoscopic-lesion-destruction
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    CPT 45388: Flexible Colonoscopy with Lesion Destruction

    Medicare pays $2782 on average nationally for this procedure.

    CPT code 45388 describes a flexible colonoscopy procedure to destroy one or more tumors, polyps, or other lesions using endoscopic techniques; the service is a therapeutic endoscopic lesion destruction performed via flexible colonoscope and typically provided in an outpatient endoscopy suite or ambulatory surgical center.

    For related coverage guidance, see recent payer policy updates: Esophagogastroduodenoscopy (EGD) Coverage Policy, Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD), Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver Disease.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old patient with intermittent rectal bleeding and a positive fecal immunochemical test undergoes a diagnostic flexible colonoscopy. During the examination the endoscopist identifies one or more sessile polyps and a friable neoplastic-appearing lesion in the sigmoid colon. The provider performs endoscopic tumor destruction and polypectomy using electrocautery and snare technique, with possible pre- and post-dilation of a partially obstructing lesion and optional guide wire passage to access the site. The typical clinical workflow includes pre-procedure evaluation and consent, moderate sedation administered by an anesthesia professional or endoscopist, colonoscopic inspection, lesion identification and treatment (ablation, snare polypectomy, or tumor debulking), hemostasis as needed, and post-procedure recovery with discharge instructions.

    Typical site of service: Ambulatory surgery center or hospital outpatient department.

    Service type: Therapeutic flexible colonoscopy with lesion destruction (endoscopic tumor/lesion ablation or removal).

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    45380Colonoscopy, flexible; with biopsy, single or multipleOften performed when a targeted biopsy is needed in addition to or instead of lesion destruction during colonoscopy.
    45385Colonoscopy, flexible; with removal of tumor(s), polyp(s), or other lesions by snare techniqueAlternative or adjunct technique when polypectomy is performed; may be reported when snare polypectomy is the primary removal method.
    45390Colonoscopy, flexible; with transendoscopic stent placementPerformed when dilation and stenting are required for obstructing colorectal lesions in conjunction with tumor debulking.
    45395Colonoscopy, flexible; with dilation of stenosis (eg, balloon, guide wire)Used when pre- or post-procedure dilation of a stricture is performed during the therapeutic colonoscopy.
    43239Upper GI endoscopy with biopsy and/or dilation (example upper GI)Not directly related anatomically but listed when concurrent upper and lower endoscopic procedures are performed in the same session; report per payer rules.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    74Modifier ‑74 indicates an outpatient hospital or ASC procedure that was discontinued after anesthesia was administered and after the procedure had begun. Use this modifier when anesthesia (local,…- Use modifier -74 when a procedure in an outpatient hospital or ASC setting is terminated after anesthesia has been administered and after the procedure has commenced (for example, after incision,…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    171WH0202XHome Modifications ContractorA contractor who makes modifications to homes to accommodate a health condition.
    376J00000XHomemakerAn individual who provides general household activities such as meal preparation, laundry, and light housekeeping, when the individual regularly respo…
    2081H0002XHospice and Palliative Medicine (Physical Medicine & Rehabilitation) PhysicianA physical medicine and rehabilitation physician with special knowledge and skills to prevent and relieve the suffering experienced by patients with l…
    164X00000XLicensed Vocational NurseAn individual with post-high school vocational training and practical experience in the provision of nursing care at a level less than that required f…
    163WG0000XGeneral Practice Registered NurseNursing Service Providers · Registered Nurse
    1835C0205XCritical Care PharmacistA licensed pharmacist who has demonstrated specialized knowledge and skill in the delivery of patient care services by pharmacists, as integral member…
    207RA0000XAdolescent Medicine (Internal Medicine) PhysicianAn internist who specializes in adolescent medicine is a multi-disciplinary healthcare specialist trained in the unique physical, psychological and so…
    2251N0400XNeurology Physical TherapistA licensed physical therapist, including but not limited to an individual who is a Board Certified Specialist in Neurologic Physical Therapy, who has …

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01
    Celiac Disease TestingOscar Health2026-10-01
    Laboratory Testing for the Diagnosis of Inflammatory Bowel DiseaseOscar Health2026-10-01
    Percutaneous Electrical Nerve Field Stimulation (PENFS)Cigna2026-09-15
    Colorectal Cancer ScreeningBlue Cross Blue Shield - New Mexico2026-09-04

    Related Codes

    CPT-45300-PROCTOSIGMOIDOSCOPY-RIGID-DIAGNOSTIC

    CPT 45300: Diagnostic Proctosigmoidoscopy with Rigid Proctoscope

    CPT-45303-PROCTOSIGMOIDOSCOPY-WITH-STRICTURE-DILATION

    CPT 45303: Proctosigmoidoscopy with Stricture Dilation

    CPT-45305-PROCTOSIGMOIDOSCOPY-WITH-BIOPSY

    CPT 45305: Proctosigmoidoscopy with Biopsy

    CPT-45307-PROCTOSIGMOIDOSCOPY-LOWER-GI-ENDOSCOPY

    CPT 45307: Proctosigmoidoscopy of Rectum and Sigmoid Colon

    CPT-45308-PROCTOSIGMOIDOSCOPIC-LESION-REMOVAL

    CPT 45308: Proctosigmoidoscopy with Removal of Single Lesion

    CPT-45309-PROCTOSIGMOIDOSCOPY-SNARE-EXCISION-LESION

    CPT 45309: Proctosigmoidoscopy with Snare Polypectomy

    CPT-45315-PROCTOSIGMOIDOSCOPIC-POLYPECTOMY-MULTIPLE-LESIONS

    CPT 45315: Proctosigmoidoscopy with Multiple Lesion Removal

    CPT-45317-PROCTOSIGMOIDOSCOPY-WITH-HEMOSTASIS

    CPT 45317: Therapeutic Proctosigmoidoscopy for Hemorrhage Control

    CPT-45320-PROCTOSIGMOIDOSCOPIC-LESION-ABLATION

    CPT 45320: Proctosigmoidoscopic Ablation of Lesion

    CPT-45321-PROCTOSIGMOIDOSCOPIC-DECOMPRESSION-SIGMOID-VOLVULUS

    CPT 45321: Proctosigmoidoscopic Decompression of Volvulus

    Showing 1–10 of 39

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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