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    v1.0.30
    OpenPayerBilling CodesExcision Procedures on the RectumCPT cpt-45108-anorectal-tumor-excision
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    CPT 45108: Excision of Tumor of Anorectal Muscle

    Medicare pays $379 on average nationally for this procedure.

    CPT code 45108 describes surgical excision of a tumor originating in the anorectal muscle with submission of the specimen for pathologic diagnostic analysis; this represents a surgical excision procedure typically performed in an operating room or procedure suite and coded as a surgical anorectal procedure for billing and documentation purposes.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 58-year-old adult who presents to colorectal surgery clinic with a solitary, palpable anorectal mass causing bleeding, pain, or altered bowel habits. After outpatient evaluation including history, physical examination with anoscopy or proctoscopy, and imaging as indicated (endorectal ultrasound or pelvic MRI), the surgeon elects excisional biopsy of the lesion under local, regional, or general anesthesia. In the operating room or procedure suite, the provider performs a full-thickness excision of the tumor involving the anorectal sphincter complex or anorectal muscular tissue, achieves hemostasis, and sends the specimen fresh or in formalin to the pathology laboratory for diagnostic histopathology and possible immunohistochemistry. Postoperative workflow includes specimen labeling and requisition, pathology processing and reporting, immediate postoperative recovery, and outpatient follow-up to review pathology results and plan further oncologic management if malignancy is identified.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    44120Enterolysis, adhesions; single band or extensivePerformed in cases where intra-abdominal adhesions are encountered during combined abdominal-perineal procedures; not typical for isolated 45108 but relevant if wider pelvic surgery is required
    45330Sigmoidoscopy, flexible; diagnostic, with or without collection of specimen by brushing or washing (separate procedure)Often performed preoperatively for evaluation of anorectal lesions and to obtain diagnostic biopsies before definitive excision
    46900Repair of obstetric laceration, third degree; 1st degree muscle injuryRelated to anorectal sphincter repair techniques and relevant when excision involves sphincter repair or reconstructive steps
    49000Exploratory laparotomy, exploratory abdominal incision; not otherwise specifiedPerformed when a combined abdominal approach is required for pelvic tumor access or staging beyond a perineal excision
    88305Surgical pathology, gross and microscopic examination, routine tissueRepresents the pathology billing for processing the excised specimen from 45108; often billed by the pathology provider as the technical component

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    2080P0207X
    208000000X
    207L00000X
    207K00000X
    376J00000X
    207RI0001X
    207XS0114X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    C20Malignant neoplasm of rectum
    C21.0Malignant neoplasm of anus, unspecified
    C21.1Malignant neoplasm of anal canal
    C21.2Malignant neoplasm of cloacogenic zone
    C21.8Malignant neoplasm of overlapping sites of rectum, anus and anal canal
    D49.2Neoplasm of unspecified behavior of bone, soft tissue, and skin
    K57.20Diverticulitis of large intestine with perforation and abscess without bleeding
    K57.30Diverticulosis of large intestine without perforation or abscess without bleeding
    K57.92Diverticulitis of intestine, part unspecified, without perforation or abscess without bleeding
    K60.0Acute anal fissure

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    CPT-45100-ANORECTAL-WALL-BIOPSY-ANAL-APPROACH

    CPT 45100: Anal Approach Anorectal Wall Biopsy

    CPT-45110-ABDOMINOPERINEAL-RESECTION-WITH-COLOSTOMY

    CPT 45110: Abdominoperineal Resection with Colostomy

    CPT-45111-PARTIAL-RECTAL-RESECTION-ABDOMINAL-APPROACH

    CPT 45111: Partial Resection of Rectum, Abdominal Approach

    CPT-45112-RECTAL-RESECTION-COLON-TO-ANUS-ANASTOMOSIS

    CPT 45112: Abdominoperineal Resection of Rectum

    CPT-45113-PROCTECTOMY-ILEOANAL-ANASTOMOSIS-ILEAL-POUCH

    CPT 45113: Partial Proctectomy with Ileoanal Anastomosis and Ileal Pouch

    CPT-45114-RECTAL-RESECTION-ANASTOMOSIS-ABDOMINAL-SACRAL-APPROACH

    CPT 45114: Abdominoperineal Resection with Colorectal Anastomosis

    CPT-45116-POSTERIOR-APPROACH-RECTAL-RESECTION-ANASTOMOSIS

    CPT 45116: Posterior Low Rectal Resection with Colon-Rectum Anastomosis

    CPT-45119-RESTORATIVE-PROCTOCOLECTOMY-WITH-COLONIC-POUCH

    CPT 45119: Abdominoperineal Proctocolectomy with Colonic Pouch

    CPT-45120-ABDOMINOPERINEAL-RECTAL-RESECTION-COLON-ANASTOMOSIS

    CPT 45120: Abdominoperineal Resection of Rectum

    CPT-45121-PULL-THROUGH-RESECTION-ABDOMINAL-PERINEAL-COLORECTAL-ANASTOMOSIS

    CPT 45121: Abdominoperineal Resection with Colon-to-Anus Anastomosis

    Showing 1–10 of 19

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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