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    OpenPayerBilling CodesIncision Procedures on the Salivary Gland and DuctsCPT cpt-42335-sialolithotomy-salivary-gland-stone-removal
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    CPT 42335: Sialolithotomy, Removal of Salivary Stone

    Medicare pays $444 on average nationally for this procedure.

    CPT code 42335 describes sialolithotomy, the surgical removal of a salivary gland stone from the duct or gland; this is a surgical procedure typically performed in an operating room or procedure suite under local or general anesthesia and involves direct excision or extraction of the calculus to relieve ductal obstruction and restore salivary flow.

    For related coverage guidance, see recent payer policy updates: Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Members, Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policy, Autologous Platelet-Derived Growth Factors (Platelet-Rich Plasma [PRP]).

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 45-year-old adult presenting to an otolaryngology clinic with acute submandibular gland pain and swelling, often worse with meals, consistent with obstructive sialolithiasis. After clinical examination and ultrasound or CT confirmation of a salivary gland stone, conservative measures (hydration, sialogogues, massage, antibiotics if infected) are attempted. When conservative therapy fails or the stone is accessible only via surgical removal, the patient is scheduled for a 42335 sialolithotomy. The procedure is performed in an outpatient ambulatory surgery center or hospital operating room under local anesthesia with sedation or general anesthesia depending on stone location and patient factors. The workflow includes preoperative consent and imaging review, intraoperative localization and incision into the duct or gland to extract the calculus, hemostasis, possible duct repair or stenting, and postoperative instructions addressing oral hygiene, pain control, and follow-up to assess gland function and wound healing. Typical postprocedure documentation includes operative report with stone size/location, approach (intraoral vs external), anesthesia type, any complications, and disposition (same-day discharge or brief observation).

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    41512Excision of submandibular gland, unilateralPerformed when sialolithiasis is intraparenchymal or gland removal is required after failed stone removal.
    42820Excision of sublingual glandRelevant when pathology involves the sublingual gland or adjacent ducts requiring gland excision.
    42450Sialendoscopy, diagnostic; major salivary gland, with or without duct dilationUsed for endoscopic evaluation and possible retrieval of stones as a less invasive alternative or adjunct to 42335.
    42415Incision and drainage, salivary gland or ductPerformed when associated infection or abscess necessitates drainage in conjunction with or prior to stone removal.
    76000Fluoroscopy, up to one hour physician timeMay be used intraoperatively for localization of radiopaque sialoliths during extraction.
    70150CT head or soft tissue neck without contrastPreoperative imaging commonly used to localize salivary stones not seen on ultrasound.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    74Modifier ‑74 indicates an outpatient hospital or ASC procedure that was discontinued after anesthesia was administered and after the procedure had begun. Use this modifier when anesthesia (local,…- Use modifier -74 when a procedure in an outpatient hospital or ASC setting is terminated after anesthesia has been administered and after the procedure has commenced (for example, after incision,…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207L00000X
    363LA2200X
    311500000X
    163WN1003X
    324500000X
    2080P0216X
    103TP2700X
    171000000X

    Related Payer Policy Updates

    Specialty: Orthopedics/Musculoskeletal1 / 3

    10 rows

    PolicyPayerEffective Date
    Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Membersuniverahealthcare2027-01-01
    Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policybcbsvermont2026-12-01
    Autologous Platelet-Derived Growth Factors (Platelet-Rich Plasma [PRP])Cigna2026-10-15
    Metatarsophalangeal Joint ReplacementCigna2026-10-15
    Shoulder Arthroplasty (Total, Partial, Reverse, Revision and Resurfacing)univerahealthcare2026-10-15
    Hip Arthroplasty (partial and total hip replacement)univerahealthcare2026-10-15
    Artificial Lumbar Intervertebral Disc (Lumbar Total Disc Arthroplasty)univerahealthcare2026-10-15
    Osteochondral Grafting of the Kneeuniverahealthcare2026-10-15
    Lumbar Fusion (arthrodesis) with decompressionuniverahealthcare2026-10-15
    Metal-on-Metal Total Hip Resurfacinguniverahealthcare2026-10-15

    Related Codes

    CPT-42300-PAROTID-ABSCESS-DRAINAGE

    CPT 42300: Drainage of Parotid Salivary Gland Abscess

    CPT-42305-PAROTID-ABSCESS-DRAINAGE-COMPLEX

    CPT 42305: Complex Drainage of Parotid Gland Abscess

    CPT-42310-INCISION-DRAINAGE-SUBMANDIBULAR-SUBLINGUAL-ABSCESS

    CPT 42310: Incision and Drainage of Submaxillary or Sublingual Salivary Gland Abscess

    CPT-42320-SUBMAXILLARY-SALIVARY-GLAND-ABSCESS-DRAINAGE-EXTERNAL-APPROACH

    CPT 42320: External Drainage of Submaxillary Salivary Gland

    CPT-42330-SIALOLITHOTOMY-REMOVAL-SALIVARY-GLAND-STONE

    CPT 42330: Sialolithotomy, Removal of Salivary Gland Stone

    CPT-42340-SIALOLITHOTOMY-PAROTID-GLAND-REMOVAL

    CPT 42340: Sialolithotomy, Parotid Gland

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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