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    v1.0.28
    OpenPayerBilling CodesExcision Procedures on the Femur (Thigh Region) and Knee JointCPT cpt-27365-femur-knee-tumor-excision
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    CPT 27365: Excision of Tumor, Femur or Knee

    Medicare pays $1860 on average nationally for this procedure.

    CPT code 27365 describes surgical excision of a tumor from the femur or knee, a surgical oncology procedure performed to remove or biopsy suspected benign or malignant bone lesions; the service is removal of a femoral or peri‑knee tumor and the typical site of service is an inpatient or outpatient surgical setting such as an operating room or ambulatory surgery center.

    For related coverage guidance, see recent payer policy updates: Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in Adults, Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in Adults, Site of Service Ambulatory Service Center (ASC) Select.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 48-year-old patient presents with progressive left distal femur pain, swelling, and occasional night pain. Imaging (radiograph and MRI) demonstrates a lytic lesion in the metaphyseal region of the distal femur suspicious for a primary bone tumor. Core needle biopsy is nondiagnostic or suggests a neoplasm requiring excision. The orthopedic oncology surgeon schedules an open excision of the tumor from the femur/knee region under general anesthesia, performs intraoperative frozen section for margin assessment, and sends tissue for permanent pathology and possible molecular testing. Perioperative workflow includes preoperative oncologic staging, anesthesia evaluation, intraoperative specimen handling, possible reconstruction (bone graft or fixation) depending on defect size, postoperative pain control, and coordination with medical oncology for adjuvant therapy if malignancy is confirmed. Typical site of service is an inpatient or ambulatory surgery center with orthopedic oncology capabilities. Typical service type is a surgical excision of a neoplasm of the femur or knee for diagnostic and therapeutic purposes.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    27075Excision of bone tumor, pelvis; marginal, wide, or radicalPelvic bone tumor excision is an analogous major musculoskeletal tumor resection often performed in the same clinical pathways and may be billed in cases involving pelvic involvement.
    27360Incision, drainage, and/or radical resection of tumor, soft tissue of thigh/knee areaSoft tissue tumor resections around the knee/thigh may be performed concurrently or in staged procedures when both bone and soft tissue tumors are present.
    20220Removal of lesion or tumor of facial bones; radical resection (example of tumor resection CPT family)Represents related tumor resection codes in other anatomic sites and is included as context for oncologic surgical coding and technique.
    19307Mastectomy, partial or segmental (included as an example of oncologic resections)Illustrates additional oncologic resection coding commonly encountered in multidisciplinary cancer care pathways.
    76942Ultrasound, guidance for needle placement (e.g., biopsy)Often used for image-guided preoperative needle biopsy to establish diagnosis prior to open excision.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    58Modifier 58 (Staged or related procedure/service by the same physician during the postoperative period) indicates that a subsequent procedure performed by the same provider during the…- Use modifier 58 when the same physician/QHP performs a procedure during the postoperative/global period of an earlier procedure and the subsequent procedure is either planned or anticipated…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207X00000XOrthopaedic Surgery PhysicianAn orthopaedic surgeon is trained in the preservation, investigation and restoration of the form and function of the extremities, spine and associated…
    163WH0500XHemodialysis Registered NurseNursing Service Providers · Registered Nurse
    2084B0002XObesity Medicine (Psychiatry & Neurology) PhysicianA physician who specializes in the treatment of obesity demonstrates competency in and a thorough understanding of the treatment of obesity and the ge…
    343900000XNon-emergency Medical Transport (VAN)A land vehicle with a capacity to meet special height, clearance, access, and seating, for the conveyance of persons in non-emergency situations. The …
    207RA0201XAllergy & Immunology (Internal Medicine) PhysicianAn internist doctor of osteopathy that specializes in the treatment of allergy and immunologic disorders. A doctor of osteopathy that is board eligib…
    207UN0902XNuclear Imaging & Therapy PhysicianA nuclear medicine physician who specializes in nuclear imaging and therapy.
    2279P3800XPalliative/Hospice Registered Respiratory TherapistA coordinated plan of care to help dying patients and their families handle the burden of terminal care. Effective secretion management and relief of…
    122400000XDenturistA denturist is a licensed professional that serves patients with removable dental prosthetic oral health needs. A licensed denturist is trained in rem…

    Related Payer Policy Updates

    Specialty: General Surgery1 / 3

    10 rows

    PolicyPayerEffective Date
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01
    Medical Necessity Guidelines — Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Ambulatory Surgery Center (ASC) - Site of Care PolicyKaiser Permanente2026-08-01
    Inpatient Surgical Site of ServiceProvidence Health Plan2026-07-01
    Removal of Implantable DevicesBlue Cross Blue Shield - Rhode Island2026-07-01

    Related Codes

    CPT-27323-EXCISIONAL-BIOPSY-THIGH-KNEE-SUPERFICIAL-SOFT-TISSUE

    CPT 27323: Excisional Biopsy of Superficial Soft Tissue, Thigh or Knee

    CPT-27324-DEEP-SOFT-TISSUE-BIOPSY-THIGH-KNEE

    CPT 27324: Deep Tissue/Muscle Biopsy of Thigh or Knee

    CPT-27325-HAMSTRING-NEURECTOMY-NERVE-EXCISION

    CPT 27325: Neurectomy of Nerve Along Hamstring

    CPT-27326-POPLITEAL-GASTROCNEMIUS-NERVE-EXCISION-FOR-SPASM

    CPT 27326: Neurectomy of Popliteal/Gastrocnemius Nerve for Spasm

    CPT-27327-SUBCUTANEOUS-TUMOR-EXCISION-THIGH-KNEE

    CPT 27327: Excision of Subcutaneous Tumor of Thigh or Knee (<3 cm)

    CPT-27328-INTRAMUSCULAR-THIGH-KNEE-TUMOR-EXCISION-SMALL

    CPT 27328: Excision of Intramuscular Tumor of Thigh or Knee (<5 cm)

    CPT-27329-EXTENSIVE-EXCISION-SOFT-TISSUE-TUMOR-THIGH-KNEE-LESS-5CM

    CPT 27329: Extensive Excision of Soft-Tissue Tumor, Thigh/Knee (<5 cm)

    CPT-27330-KNEE-SYNOVIAL-BIOPSY-SURGICAL-DIAGNOSTIC

    CPT 27330: Open Biopsy of Synovium of Knee

    CPT-27331-KNEE-ARTHROTOMY-BIOPSY-LOOSE-BODY-REMOVAL

    CPT 27331: Knee Arthrotomy with Synovial Biopsy and Loose Body Removal

    CPT-27332-KNEE-ARTHROTOMY-MENISCAL-EXCISION

    CPT 27332: Arthrotomy with Excision of Medial or Lateral Meniscus

    Showing 1–10 of 25

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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