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    OpenPayerBilling CodesExcision Procedures on the Femur (Thigh Region) and Knee JointCPT cpt-27357-femoral-bone-cyst-excision-autograft
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    CPT 27357: Femoral Bone Cyst Excision with Autograft

    Medicare pays $781 on average nationally for this procedure.

    CPT code 27357 describes surgical excision of a bone cyst from the femur with placement of an autograft; this is an orthopedic surgical procedure intended to relieve pain and improve range of motion, typically performed in an operating room or ambulatory surgery center as an open or minimally invasive femoral bone cyst removal with grafting.

    For related coverage guidance, see recent payer policy updates: Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in Adults, Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in Adults, Site of Service Ambulatory Service Center (ASC) Select.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 12–25-year-old with an expansile bone cyst in the proximal femur presenting with progressive hip or thigh pain, localized tenderness, and limited range of motion. Imaging (plain radiographs and MRI) demonstrates a solitary unicameral or aneurysmal bone cyst that threatens cortical integrity or has caused a pathologic fracture. The orthopedic surgeon schedules operative curettage of the cyst with autograft placement to obliterate the cavity, restore structural support, and relieve symptoms. The clinical workflow includes preoperative imaging and planning, informed consent discussing risks and benefits, preoperative medical clearance, anesthesia evaluation (general or regional), intraoperative cyst curettage and graft harvest (commonly from the iliac crest), placement of autologous bone graft into the femoral defect, intraoperative imaging confirmation, and standard postoperative recovery with pain control, short-term immobilization or limited weight-bearing, and outpatient orthopedic follow-up with repeat imaging to assess healing and graft incorporation.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    27357Removal bone cyst femur, autograftPrimary procedure: curettage of femoral bone cyst with placement of autologous bone graft to fill defect and restore structural integrity.
    20936Autograft for spine or other musculoskeletal reconstruction, any donor site, includes harvesting when performedUsed to report autograft harvest and placement when separate reporting is permitted alongside the primary cyst removal procedure.
    20680Removal of implant; deep (e.g., buried), requiring incision, aseptic techniqueMay be performed if prior fixation hardware is present and removed to access the cyst.
    27075Excision of lesion of pelvis, hip, femur; lesion 1 cm or greaterAlternative/additional code when excision rather than curettage is performed on a focal femoral bone lesion.
    77012CT guidance for needle placement (eg, biopsy)Used preoperatively for image-guided biopsy or localization of the cyst if needed for diagnosis prior to definitive surgery.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    207RI0200XInfectious Disease PhysicianAn internist who deals with infectious diseases of all types and in all organ systems. Conditions requiring selective use of antibiotics call for this…
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    2279P1006XPulmonary Function Technologist Registered Respiratory TherapistAn individual who is trained and qualified to perform pulmonary diagnostic tests. In the course of conducting these tests, the Pulmonary Function Tec…
    207SG0203XClinical Molecular Genetics PhysicianA clinical molecular geneticist demonstrates competence in performing and interpreting molecular analyses relevant to the diagnosis and management of …
    207SG0207XMedical Biochemical GeneticsA medical biochemical geneticist specializes in the diagnosis, evaluation, prevention, and treatment of patients with biochemical genetic disorders, d…
    364SC0200XCritical Care Medicine Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
    156FX1700XOcularistAn ocularist is a thoroughly trained professional skilled in the art of fitting, painting, and fabricating custom ocular prostheses. In addition to cr…

    Related ICD-10-CM Codes

    22 rows

    ICD-10-CM CodeDescription
    C41.4Malignant neoplasm of pelvic bones, sacrum and coccyx
    C41.9Malignant neoplasm of bone and articular cartilage, unspecified
    D16.4Benign neoplasm of bones of skull and face
    D16.9Benign neoplasm of bone and articular cartilage, unspecified
    M12.561Traumatic arthropathy, right knee
    M12.569Traumatic arthropathy, unspecified knee
    M25.561Pain in right knee
    M25.569Pain in unspecified knee
    M79.601Pain in right arm
    M84.371AStress fracture, right ankle, initial encounter for fracture

    Showing 1–10 of 22

    Related Payer Policy Updates

    Specialty: General Surgery1 / 3

    10 rows

    PolicyPayerEffective Date
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01
    Medical Necessity Guidelines — Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Ambulatory Surgery Center (ASC) - Site of Care PolicyKaiser Permanente2026-08-01
    Inpatient Surgical Site of ServiceProvidence Health Plan2026-07-01
    Removal of Implantable DevicesBlue Cross Blue Shield - Rhode Island2026-07-01

    Related Codes

    CPT-27323-EXCISIONAL-BIOPSY-THIGH-KNEE-SUPERFICIAL-SOFT-TISSUE

    CPT 27323: Excisional Biopsy of Superficial Soft Tissue, Thigh or Knee

    CPT-27324-DEEP-SOFT-TISSUE-BIOPSY-THIGH-KNEE

    CPT 27324: Deep Tissue/Muscle Biopsy of Thigh or Knee

    CPT-27325-HAMSTRING-NEURECTOMY-NERVE-EXCISION

    CPT 27325: Neurectomy of Nerve Along Hamstring

    CPT-27326-POPLITEAL-GASTROCNEMIUS-NERVE-EXCISION-FOR-SPASM

    CPT 27326: Neurectomy of Popliteal/Gastrocnemius Nerve for Spasm

    CPT-27327-SUBCUTANEOUS-TUMOR-EXCISION-THIGH-KNEE

    CPT 27327: Excision of Subcutaneous Tumor of Thigh or Knee (<3 cm)

    CPT-27328-INTRAMUSCULAR-THIGH-KNEE-TUMOR-EXCISION-SMALL

    CPT 27328: Excision of Intramuscular Tumor of Thigh or Knee (<5 cm)

    CPT-27329-EXTENSIVE-EXCISION-SOFT-TISSUE-TUMOR-THIGH-KNEE-LESS-5CM

    CPT 27329: Extensive Excision of Soft-Tissue Tumor, Thigh/Knee (<5 cm)

    CPT-27330-KNEE-SYNOVIAL-BIOPSY-SURGICAL-DIAGNOSTIC

    CPT 27330: Open Biopsy of Synovium of Knee

    CPT-27331-KNEE-ARTHROTOMY-BIOPSY-LOOSE-BODY-REMOVAL

    CPT 27331: Knee Arthrotomy with Synovial Biopsy and Loose Body Removal

    CPT-27332-KNEE-ARTHROTOMY-MENISCAL-EXCISION

    CPT 27332: Arthrotomy with Excision of Medial or Lateral Meniscus

    Showing 1–10 of 25

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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