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    v1.0.30
    OpenPayerBilling CodesAutologous Cellular Implant of Adipose Tissue for JointsCPT cpt-0566t-autologous-adipose-cellular-knee-injection
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    CPT 0566T: Autologous Adipose‑Derived Cellular Implant Injection into Knee

    CPT code 0566T describes injection of a previously prepared autologous cellular implant derived from adipose tissue harvested by liposuction, delivered under ultrasound guidance into a single knee; this is a minimally invasive injectable autologous adipose-derived cellular implant procedure typically performed in an ambulatory surgery center or outpatient procedural clinic using ultrasound for localization and injection into the affected knee joint or periarticular space.

    For related coverage guidance, see recent payer policy updates: Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Members, Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policy, Autologous Platelet-Derived Growth Factors (Platelet-Rich Plasma [PRP]).

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old patient with chronic, symptomatic osteoarthritis of the right knee refractory to conservative care (physical therapy, oral NSAIDs, corticosteroid injections) presents for autologous adipose-derived cellular implant injection. The patient previously underwent elective mini‑liposuction under local anesthesia to harvest adipose tissue; the specimen was processed off‑site or in a cell‑processing lab to produce a previously prepared autologous cellular implant. On the day of implantation the patient is evaluated in an outpatient ambulatory surgical center or office-based procedure suite. Under sterile conditions and ultrasound guidance, the provider injects the prepared implant into the affected knee joint. Typical workflow steps include pre-procedure consent and history, site marking, ultrasound review of joint anatomy, local anesthetic as needed, injection of the implant into the intra-articular or periarticular target under ultrasound visualization, brief post-procedure observation for adverse events, and discharge with activity and follow-up instructions. Common clinical monitoring includes assessment for infection, bleeding, allergic reaction, and immediate pain relief or swelling. Billing reflects a single knee injection of an autologous adipose-derived cellular implant performed under ultrasound guidance using code 0566T.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    15830Removal of implanted material (e.g., fat graft)May be used if previously placed adipose material requires removal before or after implant processing
    0499TCellular processing procedures (example)Related to the processing steps for preparation of autologous cellular implants when billed as distinct laboratory or proprietary services
    76942Ultrasound, guidance for needle placementOften reported when separate ultrasound guidance is billed in addition to the injection procedure if payer allows
    15777Supplementation of autologous adipose tissue (liposuction-related)Codes describing adipose tissue harvest or grafting that may be part of the overall clinical episode
    99214Office or other outpatient visit, established patientTypical evaluation and management code for pre-procedure or post-procedure visits associated with the injection

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207L00000X
    207X00000X
    2084P0800X
    363A00000X
    208100000X
    208U00000X
    207XS0117X
    163WE0003X

    Related ICD-10-CM Codes

    11 rows

    ICD-10-CM CodeDescription
    M17.0Bilateral primary osteoarthritis of knee
    M17.10Unilateral primary osteoarthritis, unspecified knee
    M17.11Unilateral primary osteoarthritis, right knee
    M17.12Unilateral primary osteoarthritis, left knee
    M17.2Bilateral post-traumatic osteoarthritis of knee
    M17.4Other bilateral secondary osteoarthritis of knee
    M17.5Other unilateral secondary osteoarthritis of knee
    M17.9Osteoarthritis of knee, unspecified
    M25.561Pain in right knee
    M25.562Pain in left knee

    Showing 1–10 of 11

    Related Payer Policy Updates

    Specialty: Orthopedics/Musculoskeletal1 / 3

    10 rows

    PolicyPayerEffective Date
    Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Membersuniverahealthcare2027-01-01
    Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policybcbsvermont2026-12-01
    Autologous Platelet-Derived Growth Factors (Platelet-Rich Plasma [PRP])Cigna2026-10-15
    Metatarsophalangeal Joint ReplacementCigna2026-10-15
    Shoulder Arthroplasty (Total, Partial, Reverse, Revision and Resurfacing)univerahealthcare2026-10-15
    Hip Arthroplasty (partial and total hip replacement)univerahealthcare2026-10-15
    Artificial Lumbar Intervertebral Disc (Lumbar Total Disc Arthroplasty)univerahealthcare2026-10-15
    Osteochondral Grafting of the Kneeuniverahealthcare2026-10-15
    Metal-on-Metal Total Hip Resurfacinguniverahealthcare2026-10-15
    Lumbar Fusion (arthrodesis) with decompressionuniverahealthcare2026-10-15

    Related Codes

    CPT-0565T-AUTOLOGOUS-FAT-HARVEST-KNEE-CELLULAR-IMPLANT

    CPT 0565T: Adipose Harvest and Cellular Implant for Knee Injection

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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