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    v1.0.30
    OpenPayerBilling CodesAutologous Cellular Implant of Adipose Tissue for JointsCPT cpt-0565t-autologous-fat-harvest-knee-cellular-implant
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    CPT 0565T: Adipose Harvest and Cellular Implant for Knee Injection

    CPT code 0565T describes the harvesting of autologous adipose (fat) tissue and creation of a cellular implant for injection into the patient’s knee joint, a tissue-harvesting and cellular therapy procedure performed as an operative service typically in an outpatient surgery center or hospital operating room for intra-articular knee treatment.

    For related coverage guidance, see recent payer policy updates: Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Members, Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policy, Autologous Platelet-Derived Growth Factors (Platelet-Rich Plasma [PRP]).

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old patient with symptomatic, degenerative osteoarthritis of the knee refractory to conservative measures (physical therapy, NSAIDs, intra-articular corticosteroid or hyaluronic acid injections) presents for autologous adipose-derived cellular implantation. The clinical workflow includes pre-procedure evaluation and informed consent, outpatient tumescent liposuction under local anesthesia or monitored anesthesia care to harvest subcutaneous fat (typically from the abdomen or flank), processing of the harvested adipose tissue to create a cellular implant, and image-guided intra-articular injection into the affected knee joint during the same encounter. Post-procedure monitoring occurs in the ambulatory surgery center or hospital outpatient setting; discharge with activity precautions and follow-up to assess pain, function, and potential adverse events (infection, bleeding, thromboembolism, or joint effusion).

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    0570TProcessing of autologous adipose tissue for implantation, quantification/characterization (if applicable)May be billed for additional or specific processing steps separate from harvest/creation in 0565T when defined by payer policy
    20610Arthrocentesis, aspiration and/or injection, major joint or bursa (e.g., knee)Alternative code for simple intra-articular injections; may be used when processed cellular implant is not used
    15876Suction assisted lipectomy, trunkMay describe the adipose harvesting procedure when significant liposuction beyond small-volume aspiration is performed (check payer bundling rules)
    77002Fluoroscopic guidance for needle placement (e.g., joint)May be reported when image guidance is used during intra-articular injection of the cellular implant
    76942Ultrasonic guidance for needle placementMay be reported when ultrasound guidance is used for adipose harvest or intra-articular injection
    99024Postoperative follow-up visit, global period (routine)May apply for routine postoperative visits in the global period depending on payer rules

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    101YA0400X
    2084A2900X
    261QD1600X
    2279S1500X
    226300000X
    246ZA2600X
    2080I0007X

    Related ICD-10-CM Codes

    14 rows

    ICD-10-CM CodeDescription
    M17.0Bilateral primary osteoarthritis of knee
    M17.10Unilateral primary osteoarthritis, unspecified knee
    M17.11Unilateral primary osteoarthritis, right knee
    M17.12Unilateral primary osteoarthritis, left knee
    M17.2Bilateral post-traumatic osteoarthritis of knee
    M17.4Other bilateral secondary osteoarthritis of knee
    M17.5Other unilateral secondary osteoarthritis of knee
    M17.9Osteoarthritis of knee, unspecified
    M25.461Effusion, right knee
    M25.462Effusion, left knee

    Showing 1–10 of 14

    Related Payer Policy Updates

    Specialty: Orthopedics/Musculoskeletal1 / 3

    10 rows

    PolicyPayerEffective Date
    Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Membersuniverahealthcare2027-01-01
    Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policybcbsvermont2026-12-01
    Autologous Platelet-Derived Growth Factors (Platelet-Rich Plasma [PRP])Cigna2026-10-15
    Metatarsophalangeal Joint ReplacementCigna2026-10-15
    Shoulder Arthroplasty (Total, Partial, Reverse, Revision and Resurfacing)univerahealthcare2026-10-15
    Hip Arthroplasty (partial and total hip replacement)univerahealthcare2026-10-15
    Artificial Lumbar Intervertebral Disc (Lumbar Total Disc Arthroplasty)univerahealthcare2026-10-15
    Osteochondral Grafting of the Kneeuniverahealthcare2026-10-15
    Metal-on-Metal Total Hip Resurfacinguniverahealthcare2026-10-15
    Lumbar Fusion (arthrodesis) with decompressionuniverahealthcare2026-10-15

    Related Codes

    CPT-0566T-AUTOLOGOUS-ADIPOSE-CELLULAR-KNEE-INJECTION

    CPT 0566T: Autologous Adipose‑Derived Cellular Implant Injection into Knee

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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