CPT code 0290U is a Proprietary Laboratory Analyses (PLA) code for the MindX Blood Test™ – Pain by MindX Sciences™ Inc., a laboratory test that uses next-generation sequencing (NGS) of RNA from a blood specimen to measure expression of 36 genes and applies an algorithmic analysis to generate a predictive risk score for propensity for pain; the service is a laboratory molecular diagnostic assay (proprietary blood-based gene expression test) typically performed in a clinical diagnostic laboratory or reference laboratory setting.

For related coverage guidance, see recent payer policy updates: RTM Testing of Homocysteine Metabolism-Related Conditions, Multimarker Serum Testing Related to Ovarian Cancer, Genomic Profiling for Selecting Targeted Cancer Therapies.