CPT 0574U: NanoDetect–TB™ LC–MS CFP‑10 Serum/Plasma Test

CPT code 0574U is a Proprietary Laboratory Analyses (PLA) code for NanoDetect–TB™ by NanoPin Technologies Inc., a serum or plasma liquid chromatography–mass spectrometry (LC–MS) test that detects the Mycobacterium tuberculosis CFP‑10 protein to identify active tuberculosis infection; the service is a diagnostic laboratory test typically performed in an outpatient or clinical laboratory setting and reported using PLA coding.

Customize your policy alerts

Sign up for cpt 0574U policy alerts

Get alerted when payer policies referencing 0574U are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Explore openpayer tools

View all tools

CPT 0574U: NanoDetect–TB™ LC–MS CFP‑10 Serum/Plasma Test

Customize your policy alerts

Sign up for cpt 0574U policy alerts

Get alerted when payer policies referencing 0574U are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Clinical & Coding Specifications

Clinical Context

A typical patient is an adult or adolescent presenting with signs or symptoms suggestive of active tuberculosis (TB), such as persistent cough, weight loss, night sweats, hemoptysis, or fever, or a patient with radiographic findings (eg, cavitary lung lesion) suspicious for pulmonary TB. The clinician (infectious disease specialist, pulmonologist, or primary care physician) orders 0574U (NanoDetect–TB™) when rapid, specific detection of the Mycobacterium tuberculosis CFP‑10 protein in serum or plasma will aid in diagnosing active infection, particularly when sputum is unobtainable, smear‑negative, or when prior nucleic acid tests are inconclusive.

The clinical workflow: a phlebotomy draw of serum or plasma is collected and sent to the performing laboratory, which runs the proprietary liquid chromatography–mass spectrometry (LC–MS) assay for CFP‑10. Results are reported back to the ordering clinician and integrated with clinical findings, imaging, and microbiology (eg, sputum smear, culture, NAAT) to establish the diagnosis of active TB and guide isolation, treatment initiation, and public health reporting. Typical site of service is an outpatient clinic, hospital outpatient department, or clinical laboratory receiving specimens from inpatient wards or emergency departments.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`81025`	Urinalysis, automated with microscopy	May be ordered concurrently for general infection workup and baseline renal assessment before TB therapy.
`87070`	Culture, bacterial; any other source except urine, blood or stool, aerobic	Sputum or other specimen cultures for Mycobacterium tuberculosis remain the diagnostic gold standard and are ordered alongside `0574U`.
`87481`	Infectious agent detection by nucleic acid (eg, NAAT), Mycobacterium tuberculosis complex, amplified probe technique	Molecular testing for M. tuberculosis on respiratory specimens is commonly performed before or with the CFP‑10 assay to increase diagnostic sensitivity.
`G0480`	Drug screen, definitive, any number of drugs, technical component	Baseline or concurrent testing related to therapy monitoring or evaluation of co‑ingestions that may affect treatment choices (used variably in inpatient workflows).
`36415`	Collection of venous blood by venipuncture	Phlebotomy code for specimen collection used in the outpatient or inpatient setting prior to performing `0574U`.

Related Modifiers

6 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
207RP1001X	Pulmonary Disease Physician	An internist who treats diseases of the lungs and airways. The pulmonologist diagnoses and treats cancer, pneumonia, pleurisy, asthma, occupational an…
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
364SX0200X	Oncology Clinical Nurse Specialist	Physician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
251V00000X	Voluntary or Charitable Agency	Agencies · Voluntary or Charitable
372600000X	Adult Companion	An individual who provides supervision, socialization, and non-medical care to a functionally impaired adult. Companions may assist or supervise the …
207RH0003X	Hematology & Oncology Physician	An internist doctor of osteopathy that specializes in the treatment of the combination of hematology and oncology disorders. A doctor of osteopathy t…
2251E1300X	Clinical Electrophysiology Physical Therapist	A licensed physical therapist, including but not limited to an individual who is a Board Certified Specialist in Clinical Electrophysiologic Physical …

CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Explore openpayer tools

View all tools

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`81025`	Urinalysis, automated with microscopy	May be ordered concurrently for general infection workup and baseline renal assessment before TB therapy.
`87070`	Culture, bacterial; any other source except urine, blood or stool, aerobic	Sputum or other specimen cultures for Mycobacterium tuberculosis remain the diagnostic gold standard and are ordered alongside `0574U`.
`87481`	Infectious agent detection by nucleic acid (eg, NAAT), Mycobacterium tuberculosis complex, amplified probe technique	Molecular testing for M. tuberculosis on respiratory specimens is commonly performed before or with the CFP‑10 assay to increase diagnostic sensitivity.
`G0480`	Drug screen, definitive, any number of drugs, technical component	Baseline or concurrent testing related to therapy monitoring or evaluation of co‑ingestions that may affect treatment choices (used variably in inpatient workflows).
`36415`	Collection of venous blood by venipuncture	Phlebotomy code for specimen collection used in the outpatient or inpatient setting prior to performing `0574U`.

Related Modifiers

6 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
207RP1001X	Pulmonary Disease Physician	An internist who treats diseases of the lungs and airways. The pulmonologist diagnoses and treats cancer, pneumonia, pleurisy, asthma, occupational an…
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
364SX0200X	Oncology Clinical Nurse Specialist	Physician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
251V00000X	Voluntary or Charitable Agency	Agencies · Voluntary or Charitable
372600000X	Adult Companion	An individual who provides supervision, socialization, and non-medical care to a functionally impaired adult. Companions may assist or supervise the …
207RH0003X	Hematology & Oncology Physician	An internist doctor of osteopathy that specializes in the treatment of the combination of hematology and oncology disorders. A doctor of osteopathy t…
2251E1300X	Clinical Electrophysiology Physical Therapist	A licensed physical therapist, including but not limited to an individual who is a Board Certified Specialist in Clinical Electrophysiologic Physical …

CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 0574U: NanoDetect–TB™ LC–MS CFP‑10 Serum/Plasma Test

Sign up for cpt 0574U policy alerts

OpenPayer

CPT 0574U: NanoDetect–TB™ LC–MS CFP‑10 Serum/Plasma Test

Sign up for cpt 0574U policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

CPT 0574U: NanoDetect–TB™ LC–MS CFP‑10 Serum/Plasma Test

Sign up for cpt 0574U policy alerts

CPT 0574U: NanoDetect–TB™ LC–MS CFP‑10 Serum/Plasma Test

Sign up for cpt 0574U policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does CPT code 0574U represent?

What specimen types and sites of service are appropriate for NanoDetect–TB™ (0574U)?

Which billing modifiers may be applicable when reporting 0574U?

What other tests or CPT codes are commonly ordered with 0574U?

Which payers are referenced for coverage and does the page provide reimbursement rates?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does CPT code 0574U represent?

What specimen types and sites of service are appropriate for NanoDetect–TB™ (0574U)?

Which billing modifiers may be applicable when reporting 0574U?

What other tests or CPT codes are commonly ordered with 0574U?

Which payers are referenced for coverage and does the page provide reimbursement rates?

References