Summary & Overview
CPT 0277U: Versiti Platelet Function Disorder Panel, NGS Multigene Test
CPT code 0277U denotes a Proprietary Laboratory Analyses (PLA) test: the Versiti™ Platelet Function Disorder Panel. This NGS-based panel sequences 40 genes and includes duplication/deletion analysis of the PLAU gene to aid differential diagnosis of platelet function disorders and assess familial risk for inherited conditions. As a PLA code, 0277U is specific to the manufacturer/lab and applies only to the named Versiti™ assay. Nationally, PLA codes like 0277U matter because they identify single-source molecular diagnostics that can affect coverage determinations, prior authorization workflows, and lab billing practices.
Key payers discussed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of clinical context for the assay, the typical service and specimen types, and how PLA designation shapes coding and billing. The publication summarizes payer coverage patterns, common modifier usage, and relevant clinical considerations clinicians and billing staff should be aware of when encountering 0277U. It also outlines expected documentation elements and the kinds of policy updates that most directly affect single-source genetic tests. Data not provided in the input (for example, specific payer pricing, individual payer policy language, and ICD-10 linkage) is identified as unavailable.
Billing Code Overview
CPT code 0277U is a Proprietary Laboratory Analyses (PLA) code for the Versiti™ Platelet Function Disorder Panel performed by Versiti™ Diagnostic Laboratories. The test uses next-generation sequencing (NGS) analysis of 40 genes plus duplication/deletion analysis of the PLAU gene. Report 0277U only for the Versiti™ test when performed on specimens such as blood, buccal swab, or amniotic fluid.
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Service type: Genetic testing — targeted multigene NGS panel with gene-level duplication/deletion analysis
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Typical site of service: Clinical diagnostic laboratories or specialized molecular pathology laboratories; specimens are collected in outpatient clinic settings, hospitals, or prenatal diagnostic centers
Clinical & Coding Specifications
Clinical Context
A 28-year-old woman with a lifelong history of easy bruising, prolonged bleeding after dental procedures, and a family history of a platelet function disorder is referred to a hematology clinic for genetic evaluation. Prior platelet function studies (platelet aggregation, PFA-100) suggest an inherited platelet defect but are nondiagnostic. The hematologist orders the Versiti™ Platelet Function Disorder Panel (0277U) on a blood specimen to perform next-generation sequencing of 40 genes and duplication/deletion analysis of the PLAU gene. The laboratory receives the specimen, performs DNA extraction, NGS and copy number analysis, and returns a report identifying pathogenic, likely pathogenic, or variants of uncertain significance. Results inform differential diagnosis, guide family screening, and influence management such as bleeding precautions, peri-procedural planning, and genetic counseling referrals. Typical sites of service include an outpatient hematology clinic or specialty laboratory; specimen sources include peripheral blood, buccal swab, or amniotic fluid when prenatal evaluation is indicated. Billing is performed by the testing laboratory using PLA code 0277U per manufacturer/laboratory-specific reporting rules.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
90 |