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    v1.0.28
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j0585-onabotulinumtoxina-injection-1-unit
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    HCPCS J0585: OnabotulinumtoxinA Injection, 1 Unit

    HCPCS Level II code J0585 represents billing for an injection of onabotulinumtoxinA, 1 unit, used for chemodenervation procedures; the service is a therapeutic botulinum toxin injection and the typical site of service is an outpatient clinic or physician office where focal muscle injections are performed.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only).

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    National Reimbursement Benchmarks

    National commercial rates for J0585 center on a BUCA average commercial rate of $123.30, with individual commercial carriers clustering below and above that level. Blue Cross Blue Shield shows very tight dispersion (P75–P25 = $0.80), Cigna is similarly constrained (P75–P25 = $1.50), and UnitedHealth Group is narrow as well (P75–P25 = $0.40), indicating consistent contracted pricing among those carriers. Aetna exhibits extreme spread driven by outliers (P75–P25 = $1,351.20), reflecting substantial variability in negotiated highs versus lows across markets.

    Mean and median differentials highlight concentration versus skew: Blue Cross Blue Shield, Cigna, and UnitedHealth Group have means near their medians, consistent with symmetric distributions, while Aetna’s mean ($820.60) far exceeds its median ($375.00), signaling a right-skewed distribution. The BUCA mean ($123.30) sits between the tight regional carriers and the high-variance Aetna, representing an average commercial benchmark for comparison.

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    National Payer Mean Reimbursement Rates

    State Reimbursement Rates

    State: Alaska1 / 51

    Rate by payer

    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old patient with focal cervical dystonia presents to a neurology clinic for symptomatic management of involuntary neck muscle contractions. The treating neurologist documents focal neck muscle hyperactivity with associated pain and functional impairment after conservative therapies (oral medications, physical therapy) provided insufficient relief. The clinician discusses chemodenervation with onabotulinumtoxinA and schedules an outpatient injection visit. On the day of service the patient receives focal injections of onabotulinumtoxina with the total number of units recorded and allocated to specific targeted muscles. Standard informed consent, pre-procedure medication reconciliation, and monitoring for adverse effects (dysphagia, local weakness) are performed. The procedure typically occurs in an outpatient clinic procedure room, neurology ambulatory suite, or hospital outpatient department. Billing uses HCPCS Level II code J0585 reported per unit of onabotulinumtoxina, with documentation of indication, units administered, injection sites, and post-procedure instructions. If procedural or evaluation services occur on the same day, appropriate CPT procedure or E/M codes and applicable modifiers are appended according to payer policies.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    46505

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    2084N0400XNeurology PhysicianA Neurologist specializes in the diagnosis and treatment of diseases or impaired function of the brain, spinal cord, peripheral nerves, muscles, auton…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    207R00000XInternal Medicine PhysicianA physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    281PC2000XChildren's Chronic Disease HospitalHospitals · Chronic Disease Hospital
    207QG0300XGeriatric Medicine (Family Medicine) PhysicianA family medicine physician with special knowledge of the aging process and special skills in the diagnostic, therapeutic, preventive and rehabilitati…
    347D00000XTrainAn organization or business licensed to provide passenger train service, including light rail, subway, and traditional services.
    376G00000XNursing Home AdministratorAn individual, often licensed by the state, who is responsible for the management of a nursing home.

    Related ICD-10-CM Codes

    15 rows

    ICD-10-CM CodeDescription
    G11.4Hereditary spastic paraplegia
    G24.1Genetic torsion dystonia
    G24.2Idiopathic nonfamilial dystonia
    G24.3Spasmodic torticollis
    G24.4Idiopathic orofacial dystonia
    G24.5Blepharospasm
    G24.8Other dystonia
    G24.9Dystonia, unspecified
    G25.3Myoclonus
    G25.89Other specified extrapyramidal and movement disorders

    Showing 1–10 of 15

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Chimeric Antigen Receptor (CAR) T-Cell TherapyColorado Rocky Mountain Health Plans2026-08-01
    Allogeneic Hematopoietic Progenitor Cell TherapyAmbetter Georgia2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Idaho Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for New Jersey Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Ohio Only)UnitedHealthcare2026-08-01
    Reblozyl (luspatercept-aamt) Medical Benefit Drug PolicyUnitedHealthcare2026-08-01

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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    Chemodenervation, anal fissure (injection of botulinum toxin)
    Example of botulinum toxin use in a different anatomic site; demonstrates code for specialized injection procedures
    52287Chemodenervation of bladder (botulinum toxin)Related application of botulinum toxin for detrusor overactivity; shows bladder-directed chemodenervation workflow
    64611Chemodenervation of salivary glands (botulinum toxin)Facial/salivary gland chemodenervation code; relevant when treating sialorrhea in neurologic disease
    64612Chemodenervation of other facial muscles (botulinum toxin)Directly related to facial dystonia or orofacial injections performed in the same clinical domain
    64650Chemodenervation of eyelid/orbit (botulinum toxin)Relevant for blepharospasm treatment with botulinum toxin injections into periocular muscles
    64653Chemodenervation, lacrimal gland (botulinum toxin)Related anatomic chemodenervation procedure for lacrimal hypersecretion or related disorders
    67345Chemodenervation, extraocular muscles (botulinum toxin)Used for strabismus or extraocular muscle disorders; demonstrates extraocular application of botulinum toxin