Manipulation under anesthesia (MUA) combines manual manipulation of a joint or the spine with anesthetic techniques (which may include general anesthesia, sedation, local injection, or other agents) to overcome pain, spasm, muscle contracture, or guarding so that specific manipulations, passive stretches, and maneuvers can break up adhesions and scar tissue and improve range of motion.
Clinical evidence supports the use of MUA for the knee in the setting of arthrofibrosis after total knee arthroplasty or other knee surgery or fracture, with randomized and systematic-review data showing immediate and sustained improvements in range of motion (for example, a 2024 multicenter randomized trial reported an immediate mean ROM improvement of 46° after MUA) and systematic reviews/meta-analyses showing clinically significant ROM gains especially when performed within 12 weeks post-operatively. Systematic reviews also identify rates and risk factors for MUA after procedures such as ACL reconstruction.
For the shoulder, MUA for adhesive capsulitis is supported when medical necessity criteria in the InterQual CP: Procedures, Manipulation Under Anesthesia, Shoulder are met; clinicians should refer to InterQual for the specific clinical coverage criteria.
Evidence for MUA of other joints (including ankle, hip, toe, wrist, TMJ) and for spinal MUA/medication-assisted manipulation is limited, inconsistent, and of low or methodologically weak quality. Published studies for spine and TMJ show small samples, lack of controls, and inconsistent outcomes, and major guideline groups have not supported routine use for low back pain; therefore MUA for these other indications is considered unproven/not medically necessary per the policy.