Manipulation under anesthesia (MUA) is a noninvasive procedure that pairs manual manipulation of a joint or the spine with an anesthetic (general, sedation, local injection, or other agents) to permit aggressive short-lever manipulations, passive stretches, and maneuvers intended to break adhesions and scar tissue when pain, spasm, or contracture prevent tolerated awake therapy. (See policy Description of Services.)
Evidence summarized by anatomic site:
- Knee: Multiple systematic reviews, case series, and randomized or controlled studies support MUA for postoperative knee arthrofibrosis after TKA and other knee surgery or fracture, reporting clinically meaningful immediate and longer-term improvements in range of motion (for example, a multicenter randomized trial reported a mean immediate ROM gain of 46° after MUA and several reviews report consistent ROM improvements and acceptable complication profiles).
- Shoulder: Evidence is limited but supportive when clinical eligibility is documented per InterQual CP: Procedures, Manipulation Under Anesthesia, Shoulder; medical necessity for shoulder MUA is contingent on meeting those InterQual clinical coverage criteria and documenting adherence.
- Spine and TMJ (and most other joints such as ankle, finger, hip, pelvis, wrist, toe): The literature is limited, methodologically weak, and inconsistent; narrative reviews and professional guidance note insufficient evidence of long-term safety or efficacy for spinal MUA, and TMJ and many peripheral joints have small uncontrolled series with mixed results, so MUA is considered unproven and not medically necessary for these indications.