| Ikramuddin et al. 2018 (RCT follow-up) |
| RYGB vs intensive medical management: at 5 years RYGB had higher composite triple end point (23% vs 4%) and higher % achieving HbA1c <7% (55% vs 14%) but more serious adverse events (66 vs 38). |
| LSG long-term data (Clapp et al. 2018; Felsenreich 2017; Flølo 2017) |
| Sleeve gastrectomy shows substantial early weight loss but notable long-term recidivism (~27.8% at ≥7 years) and revision rate (~19.9%); GERD/new Barrett’s and conversions to RYGB reported in long-term follow-up. |
| Intragastric balloon (IGB) trials (Spatz/Orbera/REDUCE/Obalon) |
| RCTs and registries show short-term clinically significant weight loss (e.g., Spatz %TBWL 15% at 32 weeks; REDUCE dual balloon %EWL ~25% at 24 weeks; Orbera meets ASGE PIVI), but most patients regain weight after removal and long-term clinical significance is unclear; adverse events and early removals reported. |
| Bariatric artery embolization (BAE) (Reddy 2020, meta-analyses) |
| Small sham-controlled RCT showed modest TBWL at 6 months (7.4 kg vs 3.0 kg); case-series meta-analyses report ~8.7 kg at 12 months but evidence insufficient and safety signals reported—considered investigational. |
| Gastric electrical stimulation (GES/CLGES) (Morales-Conde 2018; Paulus 2020; systematic reviews) |
| Early feasibility and cohort studies report modest weight loss (e.g., %TBWL ~14% at 12 months) and acceptable safety in small studies, but RCT-level durable evidence lacking; authors call for larger RCTs. |
| Endoscopic sleeve gastroplasty (ESG, OverStitch) (MERIT RCT, systematic reviews) |
| RCTs and meta-analyses show ESG produces meaningful weight loss vs lifestyle alone (%TWL ranges across studies) with SAE rates ~2% but generally less weight loss than surgical LSG; longer-term comparative data limited. |
| Endoscopic gastrointestinal liners (DJBL/EndoBarrier) (RCTs/observational) |
| DJBL yields significant weight/metabolic improvements while in place but has high AE rates including serious events (hepatic abscess, GI hemorrhage) and benefits often lost after removal; evidence insufficient for routine use. |
| Transoral endoscopic devices (TPS, GI bypass devices) |
| Feasibility and single-arm studies report large %EWL/%TWL at 6–12 months (e.g., TPS, gastrointestinal bypass sleeve), but RCT evidence limited and longer-term confirmation needed. |
| Stomach aspiration therapy (AspireAssist) |
| Observational and RCT-extension data report sustained weight loss up to 4 years (~17–18% TWL) with pooled SAE ~4.1%; evidence limited by study designs and patient selection. |
| Revisional/one-anastomosis/SADI concerns (OAGB/MGB, SADI-S/SADS) |
| Systematic reviews and prospective studies suggest OAGB/SADI may achieve substantial EWL and comorbidity remission but carry concerns for GERD, diarrhea, malabsorption, and nutritional disorders; long-term comparative data are limited and safety/nutrition issues noted. |