Randomized trial (2024, Abdel et al.): In a multicenter randomized trial of 124 participants after total knee arthroplasty and subsequent stiffness, MUA produced an immediate mean range-of-motion improvement of +46°; there was no long-term difference between groups receiving adjunctive anti-inflammatory therapy versus control at 6 weeks and 1 year.
Systematic review/meta-analysis (Patel et al. 2025): A systematic review and meta-analysis (53 studies, 2,931,517 individuals) identified risk factors associated with postoperative knee stiffness requiring MUA after primary total knee arthroplasty, including younger age, Black race, smoking, lower ASA score, and prior knee procedure.
Single-institution retrospective study (Walsh et al. 2024): Among cases of MUA or arthroscopic lysis of adhesions plus MUA after primary TKA, MUAs performed earlier postoperatively had lower revision rates and greater final knee flexion gains compared with combined procedures; reported expected flexion gains in successful cases were in the range of ~27° to 33°.
Multiple systematic reviews (2022–2025): Systematic reviews and meta-analyses (including Fackler et al. 2022, Haffar et al. 2022, Gu et al. 2018, Akhtar et al. 2024) report overall support for knee MUA in postoperative arthrofibrosis with improvements in ROM and functional scores, while evidence for other joints (spine, TMJ, toe, ankle, hip, finger, wrist, pelvis) is limited, inconsistent, or does not demonstrate consistent benefit.