Examples of services, procedures and drug classes that require prior authorization. This list consolidates categories, notable drug codes, procedure groups, and special-case rules (diagnosis-based exceptions and age/service setting notes).
Cancer supportive care: Prior authorization required for colony-stimulating factor drugs and bone-modifying agents administered in an outpatient setting for a cancer diagnosis. Notable HCPCS/J-codes subject to authorization: J0897, J1442, J1447, J2506, Q5101, Q5108, Q5110, Q5111, Q5120, Q5122, Q5125 (also require PA for non-oncology DX). Eflapegrastim-xnst (Rolvedon®) and other agents require PA; see Specialty Pharmacy Transactions for submission.
Bone-modifying agents: Denosumab products (Prolia®, Xgeva®) — J0897* require prior authorization.
Erythropoiesis-stimulating agents: Epoetin alfa — J0885 requires prior authorization (both oncology and non-oncology DX; PA not required for ESRD diagnosis per policy notes).
Chemotherapy injectables: Notification/prior authorization required for injectable chemotherapy drugs administered in outpatient settings for cancer diagnoses. Includes chemotherapy J-codes (J9000-J9999), leucovorin (J0640), levoleucovorin (J0641, J0642), leuprolide (J1950/J1952), lanreotide (J1932), Q-coded chemotherapy injectables, and miscellaneous unassigned HCPCS billed under miscellaneous codes.
Injectable specialty medications: Many injectable medications (including select unclassified/temporary codes C9399, J3490, J3590) require notification/prior authorization when they correspond to specific branded therapies (e.g., Nulibry™, Rivfloza™, Revcovi™) — check Specialty Pharmacy Transactions tile or call the specialty pharmacy help line.
Cardiology and selected imaging/procedures managed by eviCore: Notification/prior authorization required for both participating and non-participating providers through eviCore for listed cardiology and related procedure codes (examples include 75557, 75559, 75561, 75563, 75571-75574, 75580, 78451-78452, 93460-93461 and select CPT/052* / 0571T codes). Submit via eviCore or Provider Portal; providers may also call 1-877-PRE-AUTH or the phone numbers listed.
Cartilage implants and select musculoskeletal procedures: Prior authorization required for adults (18+) for listed cartilage implant and related codes (examples: 27412, 27415, 27416, 29866) — see Congenital Heart Disease section for pediatric exceptions.
Cerebral seizure monitoring (inpatient video EEG): Prior authorization required for inpatient services and for patients ages 18 and older for listed EEG codes (e.g., 95700-95718 variants).
Congenital heart disease: Prior authorization required. For prior authorization call 888-936-7246 or use the notification number on the member ID card.
Continuous glucose monitors (CGM): Prior authorization required when billed with Type 2 diabetes and gestational diabetes diagnosis codes. Prior authorization is not required when billed with Type 1 diabetes diagnosis codes. Example HCPCS: A4226, A4238, A4239, A9276, A9277.
Cosmetic and reconstructive procedures: Prior authorization required for many CPT codes describing cosmetic or reconstructive procedures; examples include 11950-11952, 11954, 11960, 11970-11971, 11980, 14020**, 14021**, 14061**, 14302, 15570/15572/15574, 15730, 15733, 15740, 15756, 15769, 15775-15776 and others listed in the cosmetic/reconstructive section. (See exceptions below for diagnosis-driven exemptions.)
Diagnostic and therapeutic procedures and selected genetic testing / lab services: Prior authorization required for many listed diagnostic/therapeutic CPT/HCPCS and molecular/genetic test codes performed in outpatient settings (examples: 29799, 32601, 32662, 36512-36522, 80145, 80230, 80280, 81490, 81493, 83695, 81162-81164, 81432, 81202, 81228-81229, 81277). Care providers requesting laboratory/genetic testing will be required to complete the prior authorization/notification process.
Durable medical equipment (DME): Notification/prior authorization required for listed DME codes and for DME with retail purchase or cumulative rental cost over specified thresholds (examples: A6550, A7025, A7026, A9272, A9279, A9282, A9999, B9999, E0328-E0329, E0466, E0481 — prior authorization required when retail/cumulative rental cost exceeds $500).
Eye, ear, nose and throat (ENT) and functional endoscopic sinus surgery (FESS): Prior authorization required for many ENT procedures and for FESS (example CPTs: 30117, 31237, 31240, 31253-31255, 44388*, 44392*, 44403, 45379*, 45384*, 45389). Site of service will also be reviewed as part of the prior authorization.
Gastroenterology: Prior authorization required for participating physicians for selected EGDs, capsule endoscopies, diagnostic and surveillance colonoscopies and for specified CPT codes (e.g., 44388*, 44392*, 44403, 45379*, 45384*, 45389, and codes listed on the Gastroenterology PA list accessed via Provider Portal).
Gender dysphoria treatment: Prior authorization required for numerous procedure codes when submitted with gender dysphoria diagnosis codes (F64.0, F64.1, F64.2, F64.8, F64.9, Z87.892). Examples of codes requiring PA when submitted with those diagnoses include 55970, 55980, 14001, 14041, 15734, 15738, 15750, 15757-15758, 19303, 53410, 53430, 54125, 54520, 54660, 54690, 55175, 55180, 56625, 56800 and many other listed CPTs — verify specific CPT/diagnosis pairings on Provider Portal.
Genetic testing and lab services: Prior authorization required for many outpatient genetic and molecular tests (BRCA panels and specific CPTs such as 81162-81164, 81432, 81202, 81228-81229, 81277, 81490, 81493). Providers must supply required documentation to complete the PA/notification process.
Hysterectomy and laparoscopic surgeries: Prior authorization required for specified inpatient procedures (inpatient vaginal hysterectomies require PA). Outpatient vaginal hysterectomies may not require PA; check code-level guidance. Examples of laparoscopic CPTs under review include 58150, 58152, 58180, 58292, 58541-58544, 58550.
Home health care: Prior authorization required only in outpatient settings (including the member's home) for listed home health HCPCS (examples: S9335, S9339, S9355, S9562, T1000-T1003).
Infertility and injectable therapies: Selected infertility services and injectable specialty drugs require prior authorization (examples: infertility codes 58770, 89398; injectable therapy J-codes such as J0896, J1437, J1439 and Q0138). Submit requests via the Specialty Pharmacy Transactions tile or specialty phone lines.
Inpatient admissions and post-acute services: Prior authorization and notification of admission date required for specified post-acute inpatient facilities (acute care hospitals, acute inpatient rehab, critical access hospitals, long-term acute care, skilled nursing facilities) prior to admission when applicable.
Pain management and potentially unproven services: Prior authorization required for many pain management procedures (examples: 0278T, 62320-62327, 62350, 64451, 64454, 64484, 64520, 64620, 64640, G0260) and for potentially unproven services (examples: 20985, 22505, 25259, 26340, 27275, 27860, 28446, 28890, 31634, 31660).
Physical, occupational, speech & respiratory therapy: Prior authorization required; Optum Physical Health-contracted providers must submit an initial Patient Summary Form (PSF) within 3 days of initiating treatment and receive authorization within 10 days of the initial visit. Examples of therapy CPTs: 97010, 97124, 97533, 97537, 94060, 97172, S5181, 97169, S5150, S8990, 97170, S5151, S9125, 97171, S5180.
Radiation therapy: Prior authorization required for listed radiation therapy modalities and codes (IGRT, IMRT, proton beam, select CPT/HCPCS such as 77014, 77385, 77387, 77401-77412 and G60xx series). Standard radiation therapy PA required only when obtained with certain cancer diagnosis ranges (e.g., C34.00-C34.92, C50.011-C50.929, C61, C79.51-C79.52, C84.7A, D05.00-D05.92).
Radiology services managed by eviCore: Prior authorization/notification required for certain CT, MRI, MRA, PET scans and other radiology services; submit via Provider Portal or eviCore per cardiac/radiology transaction instructions.
Durable rules and site-of-service review: Many procedures and DME authorizations include site-of-service review — inpatient vs outpatient determinations may affect PA requirements (e.g., hysterectomy site-specific guidance).
Out-of-network services: Prior authorization required for certain out-of-network referrals or for directing members to non-contracted providers; patients using non-network providers may face increased out-of-pocket costs or no coverage.
Examples are illustrative, not exhaustive: Providers must consult UnitedHealthcare Provider Portal (Prior Authorization and Notification tool), eviCore where managed, or designated phone numbers (e.g., 800-666-1353, 877-842-3210, 888-936-7246) for complete, code-level PA requirements and submission instructions.