| Acupuncture RCT (Hollifield et al. 2024) | Single RCT (n=93) verum acupuncture > sham for combat-related PTSD (between-group mean difference 7.1; P = .005); limitations include generalizability and durability. |
| Acupuncture systematic reviews/meta-analyses | Mixed evidence: some meta-analyses show benefit for sleep quality and depression severity; variable/low quality; possible dose-response with more sessions better. |
| Animal-Assisted Therapy systematic reviews (Pandey 2024, Rehn 2023, Chen 2022, Hediger 2021) | Preliminary positive findings across ASD, dementia, PTSD but studies small, heterogeneous, often low quality; limited durability and standardization. |
| Art Therapy systematic reviews | Some positive outcomes for ASD and cancer-related anxiety/depression and older adults with depression; evidence limited by small studies and heterogeneity. |
| Brainspotting (Horton 2023) | Nonrandomized controlled study (n=63) showed reduced depression and anxiety vs treatment-as-usual; small sample and variable clinician training. |
| Dance/movement Therapy systematic reviews/meta-analyses | Mixed results: some meta-analyses show no significant effects; others show reductions in depressive/anxiety/stress symptoms with methodological limitations. |
| Equine Therapy systematic reviews | Some improvements reported for ASD, PTSD, SUD, ADHD but many studies small, heterogeneous, limited durability; need rigorous trials. |
| Equine-assisted services for SUD (scoping review) | Some studies show increased treatment completion and retention but evidence limited by small samples and study quality. |
| Music therapy (Cochrane 2025) | Cochrane review in dementia: small beneficial effect for depressive symptoms (SMD -0.23); limited sustained effects beyond treatment. |
| Music therapy (Wang 2023) | Systematic review/meta-analysis in older adults with depression: SMD -1.40 favoring music therapy; low-moderate GRADE; high heterogeneity. |
| Music therapy for PTSD (Wang 2024) | Systematic review found passive music listening yielded most consistent benefits; studies small with limited long-term data. |
| Dance therapy (Christopher 2025; Karkou 2023) | Reviews/meta-analyses show mixed or minimal effects for stress/depression and dementia-related outcomes; low-certainty evidence and methodological limits. |
| Equine-assisted interventions for ASD (Xiao 2023) | Systematic review/meta-analysis (25 studies) suggests improvements in social and behavioral functioning but only 11 of 25 met high-quality standards; limited durability. |
| Equine therapy for veterans with PTSD (Li & Garcia 2023) | Systematic review (10 studies) reported symptom reductions and functional improvements but limited by small samples, lack of randomization/blinding, and limited durability data. |
| Reiki (Guo 2024) | Meta-analysis of 13 RCTs (n=824) showed anxiety reduction (SMD -0.82) with protocol variability and short-term follow-up; further research needed. |
| Naturopathic detoxification (KB220/NAAT and related) | Pilot and observational studies report improvements in abstinence/craving measures but are limited by small samples and nonrandomized designs; more rigorous trials needed. |
| Acupuncture for SUD (Hayes 2021; Krause 2020) | Reviews and RCTs show low-quality evidence with potential but unproven benefit; mixed trial results and methodological limitations. |
| Music therapy for SUD (Ghetti 2022 Cochrane) | Cochrane review: moderate reductions in craving and increased motivation as add-on to standard care; low-to-moderate confidence due to study limitations. |
| General evidence implication | Overall limited, low-to-moderate quality evidence across modalities; many studies small, heterogeneous, with short follow-up and inconsistent protocols. |