Initial Therapy — Covered when ALL of the following general requirements AND the indication-specific criteria are met
Covered when ALL of the following general requirements AND the indication‑specific criteria are met
General requirements: Submission of the member's chart/medical record documenting medical necessity; pretreatment TB screening with TB skin test or interferon gamma release assay (unless exempt because of prior biologic/targeted DMARD use); baseline disease severity assessment using an objective measure/tool; patient up to date with age-appropriate vaccinations; no concurrent live vaccines; no active infection; Cosentyx will not be used concomitantly with other injectable biologic response modifiers or specified targeted agents
General prerequisites apply to all indications
FDA-approved indications: Member has one of the listed indications: moderate to severe plaque psoriasis, active psoriatic arthritis, active ankylosing spondylitis, active non-radiographic axial spondyloarthritis, active enthesitis-related arthritis, or moderate to severe hidradenitis suppurativa
Indication-specific criteria follow
Psoriasis (age >=6): Prescribed by or in consultation with a dermatologist or rheumatologist; BSA >= 10% affected OR involvement of crucial body areas (e.g., hands, feet, face, neck, scalp, genitals/groin, intertriginous areas); and documentation of either (a) inadequate response or intolerance to >=3 months of methotrexate, cyclosporine, or acitretin OR (b) inadequate response or intolerance to >=3 months of phototherapy unless intolerant; inadequate response/intolerance to Zoryve cream within 12 months (unless BSA >20%); and inadequate response, intolerance, or contraindication to >=3 months adalimumab and >=6 months ustekinumab biosimilar at maximum tolerated doses
Initial authorization: 6 months
Psoriatic arthritis (>=2 years): Prescribed by or in consultation with a dermatologist or rheumatologist; documented moderate to severe active disease AND either (axial disease: inadequate response/intolerance to >=4-week trial of one NSAID unless contraindicated) OR (peripheral arthritis/dactylitis/active enthesitis: inadequate response to >=3-month trial of one oral DMARD such as methotrexate, azathioprine, or sulfasalazine unless intolerant); and inadequate response, intolerance, or contraindication to >=3 months adalimumab and >=6 months ustekinumab biosimilar at maximum tolerated doses; new patients must initiate at 150 mg before increasing to 300 mg unless coexistent plaque psoriasis
Initial authorization: 6 months
Ankylosing spondylitis (>=18 years): Prescribed by or in consultation with a rheumatologist; documented active disease; inadequate response or intolerance to >=2 NSAIDs over 4 weeks total unless contraindicated; and inadequate response, intolerance, or contraindication to >=3-month trial of adalimumab at maximum tolerated doses; new patients should start at 150 mg before increasing to 300 mg
Initial authorization: 6 months
Non-radiographic axial spondyloarthritis (nr-axSpA) (>=18 years): Prescribed by or in consultation with a rheumatologist; objective signs of inflammation demonstrated by elevated CRP above the upper limit of normal and/or sacroiliitis on MRI; absence of definitive radiographic sacroiliac joint damage; inadequate response or intolerance to >=2 NSAIDs over 4 weeks total unless contraindicated; and inadequate response, intolerance, or contraindication to >=3-month trial of adalimumab at maximum tolerated dosesElevated CRP above ULN and/or sacroiliitis on MRI
Initial authorization: 6 months
Enthesitis-related arthritis (ERA) (>=4 years): Prescribed by or in consultation with a rheumatologist; active disease demonstrated by >=3 active joints and at least one site of active enthesitis at baseline or by history; inadequate response or intolerance to NSAIDs, sulfasalazine, or methotrexate
Initial authorization: 6 months
Hidradenitis suppurativa (adults): Prescribed by or in consultation with a dermatologist; inadequate response to oral antibiotics for >=90 days or intolerance/contraindication to antibiotics; and inadequate response, intolerance, or contraindication to >=3-month trial of adalimumab and >=6-month trial of ustekinumab at maximum tolerated doses
Initial authorization: 6 months