| Vickers et al. (2012) meta-analysis | Acupuncture superior to sham and no‑acupuncture controls for chronic pain; modest effect vs sham (≈0.15–0.23 SD) and larger vs no‑acupuncture (≈0.42–0.57); n≈17,922 |
| NICE guideline (2021) | Mixed‑quality evidence: short‑term clinically important benefits vs sham/usual care for pain, QoL and function in some comparisons; certainty variable across outcomes and timepoints |
| Knee osteoarthritis (Cochrane & recent reviews) | May improve pain and function up to ~3–6 months post‑treatment versus sham, usual care, or some comparators; evidence low to very low certainty; adverse events generally mild (e.g., hematoma) |
| Tension‑type headache / Migraine (Cochrane reviews) | Trials/meta‑analyses show reduced headache frequency and pain vs routine care; mixed results vs sham with some trials favoring acupuncture; considered a valid nonpharmacologic option |
| Low back pain (systematic reviews/AHRQ) | Modest short‑term pain relief and some functional improvement vs sham or no treatment; certainty ranges low to moderate; effects often small and sometimes not clinically important |
| Chronic sciatica (Tu et al. 2024 RCT) | Acupuncture reduced leg pain (VAS) and ODI vs sham with benefits persisting to 52 weeks; no serious adverse events reported |
| Chemotherapy‑induced peripheral neuropathy (CIPN) reviews/meta‑analyses | Multiple reviews suggest benefit for pain, QoL and nerve conduction; evidence quality low to very low; acupuncture+electrical stimulation may be most effective |
| Nausea / P6 stimulation and CINV / PONV (Cochrane & trials) | Acupuncture and P6 stimulation effective for prevention/treatment of postoperative and chemotherapy‑induced nausea/vomiting; evidence often low certainty but consistent across many RCTs |
| Breast cancer / AI‑related arthralgia (Hershman et al., Mao/ASCO guidance) | RCTs and guidelines recommend acupuncture for aromatase inhibitor‑related joint pain; randomized trial showed reduced pain at 52 weeks |
| Acupuncture point injection therapy | Insufficient peer‑reviewed evidence to support safety and efficacy; considered experimental/investigational/unproven (policy conclusion) |
| Systematic evidence syntheses (multiple SRs/MAs) | Heterogeneous literature across conditions: benefits often small, variable durability, generally few serious adverse events; many trials small/low quality |
| Temporomandibular disorder (Busse et al. 2023) | Guideline issued conditional recommendation in favor of acupuncture for chronic TMD pain based on comparative effectiveness review |
| Durability analyses (meta‑analyses) | Some conditions (e.g., KOA, chronic pain) show effects lasting 3–6 months post‑treatment in pooled analyses, though certainty varies |
| Cancer pain / supportive care SRs | Systematic reviews find limited but suggestive evidence for symptom benefits (pain, nausea, fatigue) in cancer patients; trial sizes small and quality variable |
| Coding / Experimental use note | Acupuncture point injection when reported with standard injection CPTs (20550‑20553) is considered experimental/unproven |