Gastrointestinal Stromal Tumor (GIST): Approve for 1 year if A) patient is >= 18 years of age AND B) patient meets ONE of the following: i) patient has tried imatinib; OR ii) patient has succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumor.
FDA‑approved indication
Pancreatic Neuroendocrine Tumors: Approve for 1 year if A) patient is >= 18 years of age AND B) patient has advanced or metastatic disease.
FDA‑approved indication
Renal Cell Cancer: Approve for 1 year if A) patient is >= 18 years of age AND B) patient has relapsed or advanced disease.
FDA‑approved indication
Bone Cancer (Recurrent Chordoma): Approve for 1 year if A) patient is >= 18 years of age AND B) patient has recurrent chordoma.
Other use with supportive evidence (NCCN)
Meningioma: Approve for 1 year if A) patient is >= 18 years of age AND B) patient has recurrent or progressive disease.
Other use with supportive evidence
Myeloid/Lymphoid Neoplasms with Eosinophilia: Approve for 1 year if A) patient is >= 18 years of age AND B) patient has eosinophilia AND C) the tumor has an FLT3 rearrangement.
Other use with supportive evidence
Pheochromocytoma/Paraganglioma: Approve for 1 year if A) patient is >= 18 years of age AND B) patient has unresectable or metastatic disease.
Other use with supportive evidence
Soft Tissue Sarcoma: Approve for 1 year if A) patient is >= 18 years of age AND B) patient has ONE of the following diagnoses: i) alveolar soft part sarcoma; OR ii) angiosarcoma; OR iii) solitary fibrous tumor; OR iv) extraskeletal myxoid chondrosarcoma.
Other use with supportive evidence (NCCN)
Thymic Carcinoma: Approve for 1 year if A) patient is >= 18 years of age AND B) patient has tried at least one systemic chemotherapy regimen (examples: carboplatin, paclitaxel, cisplatin, doxorubicin, cyclophosphamide, or etoposide).
Other use with supportive evidence
Thyroid Carcinoma, Differentiated: Approve for 1 year if A) patient is >= 18 years of age AND B) patient meets ONE of the following: i) both a) papillary or follicular thyroid carcinoma AND b) disease refractory to radioactive iodine therapy; OR ii) oncocytic (formerly Hürthle cell) carcinoma.
Other use with supportive evidence
Thyroid Carcinoma, Medullary: Approve for 1 year if A) patient is >= 18 years of age AND B) patient has tried at least one systemic therapy (examples: vandetanib, cabozantinib, selpercatinib, pralsetinib).
Other use with supportive evidence