CurrentCapital BluecrossPolicy AHS - G2005 - Vitamin D Testing, 1

Vitamin D Testing

Defines when serum 25-hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D testing meet coverage criteria, limits on frequency, acceptable fraction testing (D2/D3), and lists clinical indications/conditions where testing is appropriate; includes related codes and assay discussion.

Policy Summary

PayerCapital Bluecross

PolicyVitamin D Testing

Policy CodePolicy AHS - G2005 - Vitamin D Testing, 1

Change TypeNo material change

Effective DateNov 16, 2015

Next Review Date

Key ActionDocument that the individual has an underlying disease/condition from Note 1 when ordering 25-hydroxyvitamin D testing; for 1,25-dihydroxyvitamin D testing document clinical indication consistent with Note 2.

SourceLink

POLICY UPDATE CHANGES

No material clinical or coverage changes identified in this brief (has_material_change=false).

1Retest interval (tests per 6 months allowed)

2Primary tests referenced

~30Conditions listed in Note 1 and Note 2 (approximate count)

50+References cited in this part

Scope: Defines coverage for serum 25-hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (calcitriol) testing, lists applicable CPT/HCPCS codes (primary: 82306 for 25OHD and 82652 for 1,25-dihydroxyvitamin D), acceptable fraction testing (D2/D3), and clinical indications where testing is appropriate.

Coverage stance: covered_with_criteria — 25-hydroxyvitamin D testing and 1,25-dihydroxyvitamin D testing meet coverage criteria when specified clinical criteria are met (see policy nodes/notes).

Effective / Last review dates: Effective 2015-11-16; Last review 2026-05-01.

Headline thresholds: Retest interval limit: No more than one 25-hydroxyvitamin D test every six months; deficiency threshold commonly used: <20 ng/mL (deficient) and <30 ng/mL considered insufficient by some; toxicity threshold: >200 ng/mL (>500 nmol/L).

Primary tests referenced: 25OHD (preferred biomarker for vitamin D status) and 1,25-dihydroxyvitamin D (used to evaluate disorders of vitamin D metabolism); retesting of 25OHD is limited to the six-month interval unless clinical circumstances justify otherwise.

Key thresholds and quick facts

Retest frequencyNo more than one 25-hydroxyvitamin D test every six months

Primary tests referenced25-hydroxyvitamin D and 1,25-dihydroxyvitamin D (CPT 82306, 82652)

Conditions countApproximately 30 conditions listed in Note 1 and Note 2

References count50+ references cited in policy

Coverage stancecovered_with_criteria

StatusCURRENT (last review 2026-05-01)

OpenPayer

Vitamin D Testing

Coverage Summary