The American Society of Anesthesiologists (ASA) defines Monitored Anesthesia Care (MAC) as a specific anesthesia service for diagnostic or therapeutic procedures that includes pre-procedure visit, intra-procedure care and post-procedure anesthesia management; indications include procedure type, patient clinical condition, and potential need to convert to general or regional anesthetic. MAC may include varying levels of sedation, analgesia, and anxiolysis as necessary, and providers must be prepared and qualified to convert to general anesthesia when indicated.
ASA classifies levels of sedation/analgesia into four tiers: Minimal sedation (anxiolysis), Moderate sedation/analgesia (conscious sedation), Deep sedation/analgesia, and General anesthesia, with progressively greater impairment of responsiveness and ventilatory/cardiovascular function across the continuum.
Because sedation exists on a continuum, practitioners intending to produce a given level of sedation must be able to rescue patients whose sedation becomes deeper than intended. Those administering moderate sedation should be able to rescue patients who enter deep sedation, and those administering deep sedation should be able to rescue patients who enter general anesthesia.
Propofol is increasingly used for procedural sedation due to rapid onset and fast recovery, but it can induce general anesthesia and has no pharmacologic antagonist; ASA guidance emphasizes safety concerns and states personnel must be prepared to respond to deep sedation and loss of airway protection if complications occur during sedation.