Primary eligibility: Individual is an adult and TMS is requested for treatment of major depressive disorder (MDD)
form asks to confirm adult status and indication
Pharmacologic treatment history: Documented failure to significantly respond to prior treatment: either four trials of psychopharmacologic agents in the current depressive episode OR inability to tolerate pharmacologic agents as evidenced by four trials with distinct side effects; trials should include at least two different agent classes at or above the minimum effective dose and duration
form requires four trials or intolerance and two agent classes at effective dose/duration
Augmentation therapies: Treatment trials have included at least two evidence-based augmentation therapies
augmentation therapy defined on form
Prior positive TMS response: If history of prior TMS, documented greater than 50% improvement on a standardized depressive symptom rating scale>50% improvement
form asks for rating scale and result
Psychotherapy: Trial of an evidence-based psychotherapy known to be effective for MDD with adequate frequency and duration that did not result in significant improvement
form requests psychotherapy model, frequency/duration, and outcomes
Documentation of severity: Depressive symptoms documented by a standardized rating scale that reliably measures depressive symptoms with provided scores (e.g., BDI, GDS, HAMD, IDS-SR, MADRS, PHQ-9, QIDS)
acceptable scales listed on form
Device and parameter conformity: Proposed treatment is to be administered using an FDA-approved TMS device and consistent with the manufacturer's/FDA specified stimulation parameters unless justification provided30 sessions + 3-week taper
form asks if proposed treatment matches specified parameters (5 days/week x 6 weeks then 3-week taper)
Absolute exclusions: No active seizure disorder (except ECT-induced or isolated febrile seizures in infancy without recurrence), no acute or chronic psychotic symptoms/disorders in the current depressive episode, and no disqualifying neurological conditions (epilepsy, cerebrovascular disease, dementia, increased intracranial pressure, history of repetitive or severe head trauma, or CNS tumors); no implanted magnetic-sensitive medical device located <= 30 cm from the TMS coil unless documented as safe
form lists these contraindications and implanted device proximity