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    OpenPayerPolicy UpdatesUrologyAetna microwave thermotherapy Coverage Update | Op…
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    CurrentAetnaPolicy 0682

    Microwave Thermotherapy

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    Defines Aetna's coverage stance for microwave thermotherapy (focused microwave thermotherapy/phase array thermotherapy) across multiple indications and lists related policies and coding references; affects providers requesting coverage for these therapies.

    Policy Summary
    PayerAetna
    PolicyMicrowave Thermotherapy
    Policy CodePolicy 0682
    Change TypeNo material changes
    Effective DateFeb 17, 2004
    Last ReviewSep 19, 2023
    Next Review DateJul 25, 2024
    Key ActionConfirm and document tumor size, location, intent and imaging when requesting authorization for microwave thermotherapy.
    SourceLink
    POLICY UPDATE CHANGES

    No material clinical or coverage changes in this revision.

    ≈20indications labeled experimental
    22bladder studies reviewed
    59%NMIBC recurrence reduction
    92.7%renal IAS (overall)
    4.0%bone tumor comp rate

    Coverage Criteria

    Experimental and Investigational

    Aetna considers microwave thermotherapy experimental and investigational for the following indications because of insufficient evidence of effectiveness:

    Experimental/Investigational indications: Bladder cancer; Bone cancer / limb salvage; Breast cancer; Breast cancer metastasis; Cervical ectopy; Chronic low back pain; Chronic neck pain; Chronic pelvic pain syndrome (including cancer pelvic pain); Chronic prostatitis; Dysmenorrhea; Keratoconus; Kidney cancer; Lung cancer; Nasopharyngeal cancer; Osteosarcoma; Pancreatic cancer; Rheumatoid arthritis.

    List not all-inclusive.

    Potential appropriate uses (based on available evidence)

    Considered when ALL of the following supporting elements are documented:

    Core documentation and intent: Documented diagnosis with imaging, lesion size and location, treatment intent (palliative symptom control or local tumor ablation), prior therapies and rationale for MWA over alternatives

    See imaging/follow-up schedules in documentation module

    Evidence-suggested favorable scenarios: (1) RCC ≤ 4 cm adjacent to renal sinus where initial ablation success (IAS) reported as 100% in Gao et al.; (2) painful osseous metastases or osteoid osteomas when prior conservative or systemic therapies are inadequate and short- to mid-term pain relief is the goal; (3) limb-salvage situations where intraoperative microwave devitalization has been used in retrospective series

    Data are primarily from single-center retrospective series, systematic reviews of small non-comparative studies, and Level III evidence

    Not supported / insufficient evidence

    Considered NOT supported when any of the following apply:

    Lack of guideline support: Indications where major guidelines (e.g., EAU, NCCN) do not mention microwave thermotherapy (examples cited include non‑muscle‑invasive bladder cancer, head and neck/nasopharyngeal cancer, kidney cancer, and lung or pancreatic cancers)

    Absence in guideline documents cited in the policy

    Non‑oncologic chronic pain indications: Chronic low back pain and chronic neck pain: randomized trials of therapeutic microwave diathermy did not show additional benefit over exercise or sham treatments

    RCT evidence reported in policy shows no added benefit

    Cervical ectopy: For symptomatic cervical ectopy, RCTs and meta-analysis reported better safety and effectiveness for focused ultrasound compared with microwave therapy; studies had high risk of bias

    MW therapy shown inferior or less favorable versus FU in meta-analysis

    Study eligibility examples

    Reported study eligibility and selection criteria (examples):

    Limb‑salvage microwave hyperthermia eligibility (study): Patients had at least 20‑mm distance from tumor edge to articular surface; good clinical and imaging response to neoadjuvant chemotherapy; no pathologic fracture; salvageable major arteries (posterior tibial and dorsalis pedis)

    From retrospective limb‑salvage series (Han et al. and Li et al.)

    Kidney (RCC adjacent to renal sinus) study entry (example): Patients with renal cell carcinoma adjacent to the renal sinus treated with US‑guided percutaneous MWA with contrast‑enhanced imaging performed pre‑ablation and at 1 day, 1 month, 3 months, and every 6 months after ablation; tumor size recorded with subgroup analysis for ≤4 cm versus >4 cm

    From Gao et al. retrospective study

    Osseous tumor/MWA with cementoplasty (example): Patients with painful extra‑spinal osseous metastases undergoing image‑guided MWA and cementoplasty with pain assessed by VAS pre‑procedure and at multiple post‑procedure timepoints (24 hours, 2–4 weeks, 20–24 weeks)

    From Deib et al. retrospective review

    Aetna classifies microwave thermotherapy (also referred to as focused microwave thermotherapy or focused microwave phased‑array thermotherapy) as experimental and investigational for a range of listed indications because the available evidence is insufficient to demonstrate effectiveness for these uses. Examples of indications designated experimental/investigational include bladder cancer; bone cancer/limb salvage; breast cancer and breast metastases; cervical ectopy; chronic low back pain; chronic neck pain; chronic pelvic pain syndrome; chronic prostatitis; dysmenorrhea; keratoconus; kidney cancer; lung cancer; nasopharyngeal cancer; osteosarcoma; pancreatic cancer; and rheumatoid arthritis.

    Several indications named in the policy are not supported or are not mentioned in major practice guidelines cited in the document. For example, the 2013 European Association of Urology update and the NCCN bladder cancer guideline (Version 2.2015) do not list microwave thermotherapy as a therapeutic option, and the policy also notes guideline absence for several other tumor types; this absence of guideline endorsement was a factor in classifying those indications as investigational.

    Study-based limb‑salvage use of intraoperative microwave hyperthermia has patient selection limits and contraindications reported in the literature. Eligibility in cited series included an available tumor‑to‑articular distance (for example, ≥ 20 mm from the tumor edge to the articular surface in study cohorts), good clinical and imaging response to neoadjuvant chemotherapy, absence of pathologic fracture, and salvageable major arteries. Patients who lacked adequate distance to the joint surface, had poor response to neoadjuvant therapy, pathologic fracture, or unsalvageable vascular anatomy were treated with amputation and were excluded from hyperthermia in the reports.

    The policy does not frame these procedures using the explicit phrase 'not medically necessary' in the experimental and investigational coverage section; instead, it classifies microwave thermotherapy as experimental and investigational for the listed indications and states that these indications are therefore excluded from coverage based on insufficient evidence of effectiveness.

    Randomized controlled trials of microwave diathermy for chronic low back pain and chronic neck pain did not demonstrate added clinical benefit over exercise programs or sham/unplugged treatments. Because RCT evidence failed to show superiority of microwave diathermy compared with standard conservative therapy, use of microwave diathermy for these chronic non‑oncologic pain indications is not supported by the evidence cited in the policy.

    The policy notes that the National Comprehensive Cancer Network’s kidney cancer guideline (Version 2.2017) does not mention microwave thermotherapy as a treatment option. The absence of this modality from the NCCN guideline is cited as evidence that microwave thermotherapy is not an established therapeutic option for kidney cancer in guideline recommendations.

    Coding and Billing

    HCPCS/CPT codes referencedmixed
    C9751Bronchoscopy, rigid or flexible, transbronchial ablation of lesion(s) by microwave energy, including fluoroscopic guidance, when performed, with computed tomography acquisition(s) and 3-d rendering, computer-assisted, image-guided navigation, and endobronchial ultrasound (ebus) guided transtracheal and/or transbronchial sampling (eg, aspiration[s]/biopsy[ies]) and all mediastinal and/or hilar lymph node stations or structures and therapeutic intervention(s).
    77280-77295Radiation therapy.
    ICD-10 codes noted as not covered for indications listedICD-10Not Covered
    C11.0-C11.9Malignant neoplasm of nasopharynx
    C25.0-C25.9Malignant neoplasm of pancreas
    C33-C34.92Malignant neoplasm of trachea, bronchus and lung
    C40.00-C41.9Malignant neoplasm of bone and articular cartilage of limbs
    C64.1-C64.9Malignant neoplasm of kidney, except renal pelvis
    C67.0-C67.9Malignant neoplasm of bladder
    C50.011-C50.929Malignant neoplasm of breast
    C79.81Secondary malignant neoplasm of breast
    D05.00-D05.92Carcinoma in situ of breast
    H18.601-H18.629Keratoconus
    1–10 of 17
    1/2
    Documented clinical studies and indications (no explicit billing codes in these chunks)mixed
    No codes listed
    inv-14: tumor size threshold — RCC ≤ 4 cm associated with higher initial ablation success (stat)
    Threshold (RCC)RCC ≤ 4 cm associated with higher initial ablation success (IAS 100% for ≤4 cm vs 75% for >4 cm)
    Study contextRetrospective US-guided percutaneous MWA study of 41 RCCs adjacent to renal sinus (Gao et al. 2016)
    Reported overall IASInitial ablation success achieved in 92.7% (38/41) overall
    Follow-up imaging schedule (study example)Contrast-enhanced US and CT or MR performed pre-ablation and at 1 day, 1 month, 3 months, and every 6 months after ablation
    inv-15: Tumor size threshold (RCC) — ≤ 4 cm associated with higher initial ablation success
    Actionable thresholdTumor size ≤ 4 cm (RCC) — associated with 100% initial ablation success in the cited series
    Evidence sourceGao et al. retrospective study of US-guided percutaneous MWA for RCC adjacent to renal sinus
    Clinical implicationSmaller tumors (≤4 cm) had superior IAS and favorable DFS/RRS/OS estimates in the study
    CaveatData are from a single retrospective series; guideline sources (NCCN) do not list microwave thermotherapy as an established option
    inv-16: Tumor-to-articular distance for limb-salvage eligibility — ≥ 20 mm available distance from tumor edge to articular surface
    Minimum distance≥ 20 mm available distance from tumor edge to articular surface (study eligibility for limb-salvage hyperthermia)
    Other eligibility elements (study)Good clinical and imaging response to neoadjuvant chemotherapy; no pathologic fracture; salvageable major arteries
    ContextCriteria derived from retrospective limb-salvage microwave hyperthermia series

    Provider Actions and Authorization Guidance

    Prior Authorization

    Prior authorization: tumor characteristics and intent

    Prior authorization may be required for microwave thermotherapy procedures depending on the service code and the member’s plan. When requesting prior authorization, document tumor characteristics (size, location, number of lesions) and the clinical intent of the procedure (curative, palliative, limb-sparing, pain control, or other intent). Provide prior-authorization reviewers with tumor measurements, imaging reports, and a statement of treatment intent to support clinical review.

    • Document tumor size, location, number of lesions, and clinical intent on the prior authorization request.
    • Confirm whether specific CPT/HCPCS codes referenced in the policy require prior authorization under the member’s benefit plan.
    Prior Authorization

    Prior authorization

    Prior authorization: confirm requirements with the payer and include supporting clinical documentation. If uncertain about whether a given CPT/HCPCS code for microwave procedures is covered, contact Aetna’s provider services or use the plan’s authorization portal to verify coverage and obtain any required approvals prior to scheduling.

    • Include relevant ICD-10 diagnosis codes when requesting authorization.
    • If applicable, attach prior imaging, pathology, and prior treatment history (e.g., prior chemotherapy, radiation, BCG) to the authorization submission.
    Denial Risk

    Denial risk for experimental/investigational indications

    Procedures and indications listed in this policy (for example: bladder cancer, bone cancer/limb salvage, chronic low back/neck pain, kidney cancer, osteosarcoma, and others) are considered experimental and investigational by Aetna for the listed indications and therefore are at high risk for denial when requested for these purposes.

    • Expect denial risk for microwave thermotherapy when used to treat indications listed as experimental/investigational (see policy list).
    • If proposing use outside listed indications, provide high-quality evidence and rationale; anticipate case-by-case medical review.
    Denial Risk

    Guideline absence may trigger review

    Absence of microwave thermotherapy from major guideline statements (e.g., EAU, NCCN) may prompt additional review or denial. Provide evidence-based justification if requesting coverage for indications not supported by these guidelines.

    • When guidelines do not mention the therapy, include peer-reviewed studies, systematic reviews, or RCT data to justify medical necessity.
    • For bladder cancer (NMIBC) consider including details on sequencing relative to BCG and other standard therapies.
    Note

    No explicit authorization or denial triggers in policy text

    The policy text does not specify explicit authorization or denial triggers (e.g., no numeric tumor-size cutoffs or mandated prior therapy sequences are listed). Authorization decisions will therefore be based on submitted clinical documentation and medical review.

    • Because explicit triggers are not provided, ensure completeness of records: imaging, pathology, prior treatments, and rationale for selecting microwave therapy.
    • Authorization outcomes are determined by clinical review; absence of detailed policy thresholds does not imply routine approval.
    Note

    No documentation requirements specified in these chunks

    No additional or alternative documentation requirements are specified in the provided policy chunks beyond standard prior-authorization submissions and clinical records. Follow payer-specific submission instructions and contact the plan for any additional required forms.

    • If plan-specific documentation rules exist (not included here), follow those instructions.
    • When in doubt, submit comprehensive clinical records to support medical necessity.
    Billing Rule

    Coding and diagnosis documentation

    When billing, include appropriate CPT/HCPCS and ICD-10 codes and document the diagnoses that justify the procedure. The policy contains lists of CPT/HCPCS/ICD-10 codes relevant to microwave thermotherapy—ensure claims include the correct diagnosis pointers and any required modifiers.

    • Attach imaging and operative reports that corroborate the diagnosis codes on the claim.
    • Verify each CPT/HCPCS used is appropriate for the billed indication and supported by documentation.
    Documentation Required

    Required clinical documentation

    Required clinical documentation to support authorization/medical review includes pre-procedure imaging, peri-procedural and immediate post-procedure imaging (when applicable), and follow-up imaging schedules. For example studies referenced in the policy used imaging at pre-ablation and at 1 day, 1 month, 3 months, then every 6 months post-ablation to document initial ablation success and ongoing control.

    • Provide imaging reports (CT/MR/CEUS) demonstrating tumor size and location pre-procedure.
    • Include post-procedure imaging and planned surveillance schedule to document treatment response.
    Note

    Therapeutic sequencing considerations for NMIBC

    Therapeutic sequencing: for non–muscle-invasive bladder cancer (NMIBC), chemo-hyperthermia (microwave-induced hyperthermia combined with intravesical chemotherapy) has been studied as an adjunct to intravesical chemotherapy and in settings where BCG is contraindicated or when patients are unsuitable for cystectomy. Document prior intravesical treatments (e.g., MMC, BCG), tumor recurrence history, and reason for selecting chemo-hyperthermia.

    • Indicate whether chemo-hyperthermia is being used as first-line adjuvant therapy, salvage therapy after BCG failure, or for BCG-contraindicated patients.
    • Provide recurrence history, prior treatment dates, and response to prior therapies.
    Step Therapy

    Non-oncologic conservative therapy precedence

    For non-oncologic indications such as chronic low back or neck pain, randomized trials cited in the policy found no added benefit of therapeutic microwave diathermy over exercise and education. Prioritize conservative therapies (exercise programs, education) before considering microwave approaches for these conditions and document prior conservative therapy attempts.

    • Document prior conservative treatments (physical therapy, exercise programs, medications) and their outcomes when requesting coverage for pain-related indications.
    • Note that RCT evidence did not demonstrate superiority of microwave diathermy compared with exercise/education.

    Background and Evidence Summary

    Microwave thermotherapy uses electromagnetic microwaves to raise local tissue temperature and has been investigated both as an ablative technique (microwave ablation) and as an adjunctive or hyperthermia treatment across a range of malignant and non‑malignant conditions. The clinical evidence summarized in the policy is largely comprised of pilot studies, retrospective series and some phase II work; for most listed indications there is insufficient high‑quality comparative evidence to establish effectiveness, and therefore these applications are considered experimental and investigational.

    Definitions

    inv-34: Microwave — electromagnetic wave definition (short gloss)
    Definition (gloss)Microwave: an electromagnetic wave with a wavelength between that of infrared and short waves.
    Physical domainElectromagnetic spectrum between infrared and short waves, used to transfer energy as heat in tissues.
    Clinical relevanceMicrowave energy is the basis for thermotherapy and ablation techniques described in this policy.
    inv-35: Microwave thermotherapy (FMT/MwHT/MWA) — alternate names and short definition
    Alternate namesAlso referred to as focused microwave thermotherapy, focused microwave phased array thermotherapy, microwave-induced hyperthermia, or microwave ablation.
    Short definitionA technique using microwave energy to raise local tissue temperature for therapeutic hyperthermia or ablation.
    Evidence noteConsidered experimental and investigational for multiple indications due to insufficient evidence of effectiveness.
    inv-16: Microwave ablation (MWA) — image-guided antenna technique definition and theorized advantages
    Definition (technique)Microwave ablation (MWA) is an image-guided technique where a microwave antenna is placed into a tumor to generate thermal necrosis.
    Theorized advantagesMay achieve higher intratumoral temperatures, larger ablation volumes, reduced treatment times, and improved convection compared with radiofrequency ablation.
    Procedure noteAdministered similarly to radiofrequency ablation with imaging localization and percutaneous antenna placement.
    inv-37: Microwave thermokeratoplasty — corneal reshaping microwave-based therapy definition
    DefinitionMicrowave thermokeratoplasty: a microwave-based thermotherapy applied to the cornea (studied combined with accelerated corneal collagen crosslinking) intended to reshape corneal curvature in keratoconus.
    Study outcomeIn a prospective trial, initial improvements in UDVA and K values were observed but effects largely regressed by 6–12 months, indicating need for further development.
    Safety noteNo significant endothelial cell loss or loss of corrected distance visual acuity at 12 months in the cited small trial.
    inv-38: Microwave thermotherapy / microwave ablation (MWA / MTA) — general technique definition with delivery notes
    General definitionMicrowave thermotherapy / microwave ablation (MWA/MTA) uses microwave energy to raise local tissue temperature for tumor ablation or hyperthermia, delivered percutaneously under imaging guidance or intraoperatively for limb-salvage procedures.
    Delivery notesTechniques include percutaneous image-guided antenna placement (MWA), focused phased-array approaches, and intraoperative devitalization in limb-salvage surgeries.
    Evidence contextClinical experience includes retrospective series for kidney tumors and limb-salvage osteosarcoma; evidence remains limited and largely nonrandomized.
    inv-39: MSTS score — Musculoskeletal Tumor Society functional score definition
    DefinitionMSTS score: Musculoskeletal Tumor Society functional score used to assess postoperative limb function.
    Usage exampleIn a retrospective limb-salvage study, mean ± SD MSTS scores were 85% ± 6% (hyperthermia) versus 66% ± 5% (amputation), indicating functional advantage with microwave-induced hyperthermia.
    InterpretationHigher MSTS percentage reflects better postoperative limb function; reported differences in the cited study were statistically significant (p = 0.008).

    Revision History

    2023-09-19last_reviewLatest

    Policy last reviewed on 2023-09-19.

    2004-02-17effective_date

    Policy originally became effective on 2004-02-17.

    2024-07-25next_review

    Next scheduled policy review date is 2024-07-25.

    Policy Summary
    PayerAetna
    PolicyMicrowave Thermotherapy
    Policy CodePolicy 0682
    Change TypeNo material changes
    Effective DateFeb 17, 2004
    Last ReviewSep 19, 2023
    Next Review DateJul 25, 2024
    Key ActionConfirm and document tumor size, location, intent and imaging when requesting authorization for microwave thermotherapy.
    SourceLink
    On This Page
    Coverage CriteriaCoding and BillingProvider Actions and Authorization GuidanceBackground and Evidence SummaryDefinitionsRevision History

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