There is insufficient evidence of the efficacy of acupuncture as a treatment for fibromyalgia (AHRQ technology assessment, 2003).
Evidence supports acupuncture for migraine: randomized trials (eg, Vickers et al 2004; Allais et al 2003; Linde et al 2009) found clinically relevant benefits versus usual care or placebo in some studies.
Insufficient evidence exists for acupuncture for insomnia; further randomized trials are needed (Sok et al, 2003).
Some evidence supports acupuncture for hip and knee osteoarthritis, but benefits are small and may be due in part to placebo effects (Manheimer et al, 2010; Berman et al, 2004).
Acupuncture has demonstrated benefit for chronic low back pain in multiple studies and guidelines (eg, ACP 2017) recommend acupuncture as a nonpharmacologic option; however effects may be similar to other active therapies and often short-term.
Evidence regarding acupuncture and moxibustion for correction of breech presentation is inconsistent; systematic reviews (Coyle et al 2005) concluded insufficient evidence to recommend routine use.
Systematic reviews found no reliable evidence for acupuncture in xerostomia and insufficient evidence for irritable bowel syndrome and allergic rhinitis/asthma.
Acupuncture for Bell's palsy: Cochrane review (Chen et al 2010) found trials of inadequate quality to draw conclusions.
There is insufficient evidence to support acupuncture for respiratory symptoms and dyspnea palliation in cancer or advanced COPD (Ben-Aharon et al 2008; Bausewein et al 2008; Gibson et al 2010; Marciniuk et al 2011).
Limited or low-quality evidence exists across many other indications (examples below); most reviews cite small trials, heterogeneity, and methodological flaws that preclude firm conclusions:
- Dry eye: limited evidence with small trials showing improvements in some measures but overall low quality (Lee et al, 2011).
- Amblyopia (anisometropic): small randomized crossover trial reported adjunctive benefit but further study needed (Lam et al, 2011).
- Autism spectrum disorders: Cochrane review (Cheuk et al, 2011) found inadequate evidence; most trials poor quality and inconsistent.
- Chronic constipation: a large RCT reported benefit of electro-acupuncture versus sham for complete spontaneous bowel movements but longer-term data and blinding limitations remain (Liu et al, 2016).
- Cancer-related indications (fatigue, pain, lymphedema, hot flashes, sleep disturbance): systematic reviews/meta-analyses show mixed results with heterogeneity and limited-quality evidence; some trials suggest benefit for specific outcomes but overall conclusions call for more rigorous trials.
- Neuropathic pain: Cochrane review (Ju et al, 2017) found very low-quality evidence and insufficient data to support or refute acupuncture for neuropathic pain.
- Occipital neuralgia, oral ulcer, renal colic: recent meta-analyses report positive findings but are limited by small, heterogeneous, and often low-quality trials; higher-quality, multicenter RCTs are needed.
- Pediatric indications: systematic reviews found promising results for some conditions (eg, amblyopia, cerebral palsy, nocturnal enuresis) but overall many pediatric reviews were low quality and conclusions cautious (Yang et al, 2015).
- Numerous other indications (eg, Alzheimer’s disease, PTSD, alcohol withdrawal, osteoporosis, obstructive sleep apnea, diabetic gastroparesis, mild cognitive impairment, restless legs syndrome, plantar fasciitis, peptic ulcer, post-operative ileus, post-stroke shoulder pain, premature ejaculation, PMS/PMDD, sexual dysfunction, abdominal obesity, non-alcoholic fatty liver disease, osteoporotic fracture pain, Parkinson’s-related fatigue) have been evaluated in systematic reviews or RCTs with mixed or low-quality evidence; common themes are small sample sizes, heterogeneity of interventions, risk of bias, and need for larger rigorous trials.
Dry needling: evidence is mixed. Some RCTs suggest short-term pain reduction for myofascial trigger point syndromes (eg, Kietrys et al, 2013) but overall quality is low-to-moderate, longer-term benefits are uncertain, and professional organizations differ in their characterizations of dry needling versus acupuncture. Many reviewers conclude dry needling/dry needling-related trigger point injections lack consistent evidence as sole treatment for chronic non-malignant pain and should be considered investigational in many contexts.
Across conditions, methodological limitations (small trials, inadequate randomization or blinding, heterogeneous acupuncture techniques and comparators, subjective outcomes, publication bias, and predominance of single-country studies) limit confidence in effect estimates. High-quality, adequately powered, blinded (where feasible), multicenter RCTs with standardized interventions and clinically relevant objective outcomes are needed to clarify the effectiveness and safety of acupuncture and related techniques.