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    v1.0.31
    OpenPayerBilling CodesTemporary National Codes (Non-Medicare)HCPCS hcpcs-s9357-home-enzyme-replacement-infusion-administration
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    HCPCS S9357: Home Infusion Enzyme Replacement Therapy Administrative Services

    HCPCS Level II code S9357 describes a per diem home infusion therapy administrative and professional services bundle for enzyme replacement intravenous therapy (for example, imiglucerase), covering care coordination, professional pharmacy services, and necessary supplies and equipment while drugs and nursing visits are billed separately; service type is home infusion therapy administrative and coordination, and the typical site of service is the patient’s home (home health/home infusion setting).

    For related coverage guidance, see recent payer policy updates: Non-Emergency Facility to Facility Transfers, Non-Emergency Facility to Facility Transfers, Medical Necessity Guidelines Non-Emergency Transportation.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult with a confirmed lysosomal storage disorder such as Gaucher disease requiring regular enzyme replacement therapy (ERT) administered intravenously at home. The patient has an established treatment plan from a hematologist or metabolic specialist and receives home infusion services ordered by the treating physician. A certified home infusion pharmacy coordinates delivery of the enzyme product (billed separately), provides professional pharmacy services, supplies infusion equipment and disposables, and arranges nursing visits for vascular access, infusion administration, and patient monitoring. Per diem administrative services include prior authorization support, care coordination with the specialty clinic, education for the patient and caregiver on infusion procedures and adverse event recognition, and documentation of each infusion encounter. Typical workflow: physician orders ERT and home infusion per diem S9357; prior authorization and benefit verification are completed; home infusion pharmacy prepares schedule and ships supplies; a licensed nurse performs pre-infusion assessment, vascular access, infusion set-up, monitors vital signs during infusion, documents the encounter, and communicates any adverse events to the physician; pharmacy manages ongoing scheduling, medication logistics, and claims submission. The typical site of service is the patient’s home or other community residence where safe infusion can occur under nursing supervision.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96521Refusal of oral intake, replacement therapy, intravenous infusion technique requiring injection or infusion pump, initial 1 hourUsed when a nurse initiates and manages an infusion pump-based therapy session during a home infusion visit; may describe infusion technique time-based reporting when applicable.
    96365Intravenous infusion, therapeutic, prophylactic, or diagnostic; initial, up to 1 hourCodes nursing/infusion time for administration of intravenous therapies when billed separately from the per diem.
    96366Intravenous infusion, each additional hour (List separately in addition to code for primary service)Used for additional infusion time beyond initial hour when infusion duration exceeds base coding and is billed separately.
    36556Insertion of non-tunneled centrally inserted central venous catheter; age 5 years or olderBilled when central venous access is placed in a hospital or outpatient setting prior to home infusion; access procedures are performed before initiating home ERT.
    36415Collection of venous blood by venipunctureUsed for routine laboratory monitoring draws related to therapy; often performed prior to or during home infusion visits if indicated.
    99213Office or other outpatient visit for the evaluation and management of an established patient, typically 15 minutesUsed for periodic clinic follow-up visits by the ordering physician to assess response and manage ongoing therapy separate from home infusion per diem.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208D00000X
    207P00000X
    163WL0100X
    207QP0002X
    2080P0202X
    207QA0505X
    2279G1100X
    2278P1006X

    Related Payer Policy Updates

    Specialty: Emergency & Medical Transportation1 / 3

    10 rows

    PolicyPayerEffective Date
    Non-Emergency Facility to Facility TransfersCareSource Georgia2026-11-01
    Non-Emergency Facility to Facility Transferscaresourcegeorgia2026-11-01
    Medical Necessity Guidelines Non-Emergency TransportationMass General Brigham Health Plan2026-11-01
    Non-Emergent Transportation Medical PolicyHealth-New-England2026-11-01
    Non-Emergency Facility to Facility Transfershap_caresource_mi_coordinated_health2026-11-01
    Ambulance and Medical Transport Services (Ground, Air and Water) Corporate Medical Policybcbsvermont2026-10-01
    Emergency Air/Water Ambulance Services Medical GuidelineWPS Health Insurance2026-10-01
    Non-Emergent Ambulance ServicesConnectiCare2026-09-11
    Fixed Wing Air Ambulance TransportCigna2026-08-15
    Air AmbulanceAmbetter Georgia2026-08-01

    Related Codes

    HCPCS-LEVEL-II-S2152-SOLID-ORGAN-TRANSPLANTATION-GLOBAL-CARE

    HCPCS Level II S2152: Solid Organ Procurement and Transplantation

    HCPCS-LEVEL-II-S2266-INDUCED-ABORTION-29-TO-31-WEEKS

    HCPCS Level II S2266: Induced Abortion, 29 to 31 Weeks

    HCPCS-LEVEL-II-S3630-EOSINOPHIL-COUNT-BLOOD-DIRECT

    HCPCS Level II S3630: Eosinophil Count, Blood, Direct

    HCPCS-LEVEL-II-S4017-INCOMPLETE-ART-CYCLE-CANCELLED-PRIOR-TO-STIMULATION

    HCPCS Level II S4017: Incomplete Cycle — Cancelled Prior to Stimulation

    HCPCS-LEVEL-II-S8055-ULTRASOUND-GUIDANCE-MULTIFETAL-REDUCTION-TC

    HCPCS Level II S8055: Ultrasound Guidance for Multifetal Pregnancy Reduction

    HCPCS-LEVEL-II-S8940-EQUESTRIAN-HIPPOTHERAPY-PER-SESSION

    HCPCS Level II S8940: Equestrian/Hippotherapy, Per Session

    HCPCS-LEVEL-II-S9024-PARANASAL-SINUS-ULTRASOUND

    HCPCS Level II S9024: Paranasal Sinus Ultrasound

    HCPCS-LEVEL-II-S9366-HOME-TPN-1-2L-PER-DAY-HOME-INFUSION

    HCPCS Level II S9366: Home Infusion TPN, 1–2 L/day

    HCPCS-LEVEL-II-S9446-GROUP-PATIENT-EDUCATION-NON-PHYSICIAN

    HCPCS S9446: Patient Education, Non-Physician Provider, Group, Per Session

    HCPCS-LEVEL-II-S9451-EXERCISE-CLASS-NON-PHYSICIAN-SESSION

    HCPCS S9451: Exercise Classes, Non-Physician Provider, Per Session

    Showing 1–10 of 532

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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