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    OpenPayerBilling CodesTemporary CodesHCPCS hcpcs-q4277-woundplus-membrane-e-graft-per-sq-cm
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    HCPCS Q4277: Woundplus membrane or e-graft, per sq cm

    HCPCS Level II code Q4277 describes the Woundplus membrane or e-graft billed per square centimeter, representing a biologic wound care membrane product used for soft tissue and wound repair; service type: application of a biologic membrane graft; typical site of service: outpatient wound care centers, hospital outpatient departments, or ambulatory surgical centers where grafts are applied.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient receiving Q4277 is an adult with a non-healing full-thickness or complex partial-thickness skin defect such as a chronic diabetic foot ulcer, venous stasis ulcer, or a surgical dehiscence where advanced biologic wound matrix therapy is indicated. The wound is measured in square centimeters and the Q4277 product (Woundplus membrane or e-graft) is applied in the outpatient wound clinic, specialty clinic, or ambulatory surgery center.

    Clinical workflow: the wound is assessed and measured, appropriate debridement is performed (sharp, mechanical, or enzymatic) and infection control measures addressed. Hemostasis is obtained, the site is prepared with sterile technique, and the Q4277 membrane is trimmed to size and applied to the wound bed. The graft is secured with sutures, staples, adhesive, or secondary dressing as clinically indicated. Post-application dressing and patient instructions are provided, and follow-up visits are scheduled for assessment, dressing changes, and possible reapplication. Providers typically document size in square centimeters, indication, debridement performed, vascular status, infection status, and precise product units billed as Q4277 per square centimeter.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    11042Debridement, subcutaneous tissue, first 20 sq cm or lessOften performed immediately prior to application of Q4277 to prepare the wound bed.
    97597Debridement (eg, high pressure waterjet, sharp) epithelialized roll under 20 sq cm, first 20 sq cmUsed for selective debridement and may be billed with documentation when applicable before graft placement.
    15271Application of a skin substitute graft to trunk, arms, legs; first 100 sq cm or less, or per square centimeter codes depending on productOften performed alongside biologic membranes; CPT codes for skin substitute application may represent related procedural coding in facility or physician contexts.
    13131Repair, complex, forehead, cheeks, chin, mouth, eyelids, nose, ears; 2.1 cm to 7.5 cmUsed when complex wound closure or reconstruction is performed in addition to or instead of membrane application.
    12002Simple repair of superficial wounds; 2.6 cm to 7.5 cmMay be used for closure of donor sites or adjacent simple repairs associated with wound management.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    207P00000XEmergency Medicine PhysicianAn emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    207SG0201XClinical Genetics (M.D.) PhysicianA clinical geneticist demonstrates competence in providing comprehensive diagnostic, management and counseling services for genetic disorders.
    2080P0208XPediatric Infectious Diseases PhysicianA pediatrician trained to care for children in the diagnosis, treatment and prevention of infectious diseases. This specialist can apply specific know…
    3336L0003XLong Term Care PharmacyA pharmacy that dispenses medicinal preparations delivered to patients residing within an intermediate or skilled nursing facility, including intermed…
    261QA1903XAmbulatory Surgical Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    A48.1Legionnaires' disease
    B95.61Methicillin susceptible Staphylococcus aureus infection as the cause of diseases classified elsewhere
    D60.9Acquired pure red cell aplasia, unspecified
    D64.9Anemia, unspecified
    E10.621Type 1 diabetes mellitus with foot ulcer
    E11.621Type 2 diabetes mellitus with foot ulcer
    G62.9Polyneuropathy, unspecified
    I70.211Atherosclerosis of native arteries of extremities with intermittent claudication, right leg
    I83.019Varicose veins of right lower extremity with ulcer of unspecified site
    K86.1Other chronic pancreatitis

    Showing 1–10 of 27

    Related Codes

    HCPCS-LEVEL-II-Q4139-INJECTABLE-AMNIOMATRIX-BIODMATRIX-1-CC

    HCPCS Q4139: Amniomatrix or Biodmatrix, Injectable, 1 cc

    HCPCS-LEVEL-II-Q4256-AREA-BASED-PROCEDURAL-ADD-ON-PER-SQ-CM

    HCPCS Q4256: MLG-complete Skin Graft Material, Per Sq Cm

    HCPCS-LEVEL-II-Q5132-ADALIMUMAB-AFZB-ABRILADA-10MG-INJECTION

    HCPCS Level II Q5132: Injection, adalimumab-afzb (Abrilada), 10 mg

    HCPCS-Q0035-CARDIOKYMOGRAPHY-CARDIAC-MOTION-RECORDING

    HCPCS Level II Q0035: Cardiokymography

    HCPCS-Q0081-INFUSION-THERAPY-NON-CHEMOTHERAPEUTIC-PER-VISIT

    HCPCS Level II Q0081: Infusion Therapy, Non‑Chemotherapeutic, Per Visit

    HCPCS-Q0083-CHEMOTHERAPY-NON-INFUSION-ADMINISTRATION

    HCPCS Q0083: Chemotherapy Administration, Non-Infusion Methods

    HCPCS-Q0084-CHEMOTHERAPY-INFUSION-ADMINISTRATION-PER-VISIT

    HCPCS Q0084: Chemotherapy Infusion Administration, Per Visit

    HCPCS-Q0085-CHEMOTHERAPY-INFUSION-PLUS-OTHER-TECHNIQUES-PER-VISIT

    HCPCS Q0085: Chemotherapy Infusion Plus Other Technique(s), Per Visit

    HCPCS-Q0091-PAP-SMEAR-SPECIMEN-COLLECTION-TRANSPORT

    HCPCS Q0091: Screening Papanicolaou Smear Collection and Transport

    HCPCS-Q0092-PORTABLE-XRAY-EQUIPMENT-SETUP

    HCPCS Q0092: Set-up Portable X-ray Equipment

    Showing 1–10 of 629

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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