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    v1.0.28
    OpenPayerBilling CodesTemporary CodesHCPCS hcpcs-q4265-neostim-per-sq-cm-add-on
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    HCPCS Level II Q4265: Neostim per Square Centimeter (Add-on)

    HCPCS Level II code Q4265 describes billing for Neostim therapy applied per square centimeter as an add-on procedure billed in addition to a primary procedure; the service represents a localized neuromodulation stimulation product or technique and is typically used as a procedure-level supply or device component provided during an outpatient or facility-based procedure such as wound care or localized stimulation in a clinic or ambulatory surgery setting.

    For related coverage guidance, see recent payer policy updates: B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays, Hepatitis Testing (A, B, C, D) Coverage Criteria.

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    Clinical & Coding Specifications

    Clinical Context

    A patient with chronic wound-related pain or impaired wound healing after surgical debridement presents to an outpatient wound care clinic or hospital inpatient service. The clinician applies a topical neurostimulation agent, billed as Q4265 (Neostim tl, per square centimeter), as an add-on to a primary wound care procedure such as debridement, negative-pressure wound therapy dressing change, or complex dressing application. Typical workflow: wound assessment and measurement; documentation of wound size in square centimeters; preparation of wound bed; application of the neostimulation topical agent to the measured wound surface; photographing and documenting the area treated and quantity applied (area × unit dosing); billing Q4265 as an add-on code in conjunction with the primary procedure code for the debridement or other wound intervention; application of appropriate modifiers based on circumstance (e.g., anesthesia, increased procedural services, discontinued procedure, assistant surgeon). Typical sites of service include outpatient wound care clinics, ambulatory surgery centers, emergency departments, and inpatient acute care units. Typical patient scenarios include diabetic foot ulcers, venous stasis ulcers, pressure injuries, or post-surgical wounds with delayed healing where topical neurostimulation is used to promote local neuromodulation and analgesia as an adjunct to primary wound therapy.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    11042Debridement, subcutaneous tissue (eg, carbuncle, cutaneous abscess), first 20 sq cm or lessCommonly billed when surgical debridement of necrotic tissue is performed prior to application of a topical neurostimulation agent billed with Q4265.
    97607Negative pressure wound therapy application, dressing change; simple or complexOften performed before or after topical agent application as part of comprehensive wound management.
    15271Application of skin substitute graft to trunk, arms, legs; first 100 sq cm or less, or major portion of graftMay be performed in conjunction with topical adjuncts during reconstruction or grafting procedures where neuromodulatory agents are used adjunctively.
    97597Debridement (eg, high-pressure waterjet, sharp); selective debridement including topical application for wound bed preparation, first 20 sq cmUsed for selective debridement services where topical agents may be applied immediately following the procedure.
    99070Supplies and materials (except eyeglasses), noncovered items, used during patient care, billed when specific supply is not included in procedure codeUsed to report additional supplies when the topical agent or its delivery supplies are not included in the primary procedure and must be separately billed.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    163W00000XRegistered Nurse(1) A registered nurse is a person qualified by graduation from an accredited nursing school (depending upon schooling, a registered nurse may receive…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    174400000XSpecialistAn individual educated and trained in an applied knowledge discipline used in the performance of work at a level requiring knowledge and skills beyond…
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    156FX1101XOphthalmic AssistantAn ophthalmic assistant assists ophthalmologists by performing duties including, but not limited to, patient charting, patient education, and basic ey…
    261QR0800XRecovery Care Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    163WC1500XCommunity Health Registered NurseNursing Service Providers · Registered Nurse

    Related ICD-10-CM Codes

    17 rows

    ICD-10-CM CodeDescription
    E11.40Type 2 diabetes mellitus with diabetic neuropathy, unspecified
    G56.01Carpal tunnel syndrome, right upper limb
    G56.02Carpal tunnel syndrome, left upper limb
    G58.0Intercostal neuropathy
    G60.0Hereditary motor and sensory neuropathy
    G60.9Hereditary and idiopathic neuropathy, unspecified
    G62.9Polyneuropathy, unspecified
    G89.0Central pain syndrome
    G89.4Chronic pain syndrome
    L59.9Disorder of the skin and subcutaneous tissue related to radiation, unspecified

    Showing 1–10 of 17

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    9 rows

    PolicyPayerEffective Date
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Testing for Vector-Borne InfectionsOscar Health2026-10-01
    Coronavirus Testing in the Outpatient SettingOscar Health2026-10-01
    Testing for Diagnosis of Active or Latent TuberculosisOscar Health2026-10-01

    Related Codes

    HCPCS-LEVEL-II-Q4139-INJECTABLE-AMNIOMATRIX-BIODMATRIX-1-CC

    HCPCS Q4139: Amniomatrix or Biodmatrix, Injectable, 1 cc

    HCPCS-LEVEL-II-Q4256-AREA-BASED-PROCEDURAL-ADD-ON-PER-SQ-CM

    HCPCS Q4256: MLG-complete Skin Graft Material, Per Sq Cm

    HCPCS-LEVEL-II-Q5132-ADALIMUMAB-AFZB-ABRILADA-10MG-INJECTION

    HCPCS Level II Q5132: Injection, adalimumab-afzb (Abrilada), 10 mg

    HCPCS-Q0035-CARDIOKYMOGRAPHY-CARDIAC-MOTION-RECORDING

    HCPCS Level II Q0035: Cardiokymography

    HCPCS-Q0081-INFUSION-THERAPY-NON-CHEMOTHERAPEUTIC-PER-VISIT

    HCPCS Level II Q0081: Infusion Therapy, Non‑Chemotherapeutic, Per Visit

    HCPCS-Q0083-CHEMOTHERAPY-NON-INFUSION-ADMINISTRATION

    HCPCS Q0083: Chemotherapy Administration, Non-Infusion Methods

    HCPCS-Q0084-CHEMOTHERAPY-INFUSION-ADMINISTRATION-PER-VISIT

    HCPCS Q0084: Chemotherapy Infusion Administration, Per Visit

    HCPCS-Q0085-CHEMOTHERAPY-INFUSION-PLUS-OTHER-TECHNIQUES-PER-VISIT

    HCPCS Q0085: Chemotherapy Infusion Plus Other Technique(s), Per Visit

    HCPCS-Q0091-PAP-SMEAR-SPECIMEN-COLLECTION-TRANSPORT

    HCPCS Q0091: Screening Papanicolaou Smear Collection and Transport

    HCPCS-Q0092-PORTABLE-XRAY-EQUIPMENT-SETUP

    HCPCS Q0092: Set-up Portable X-ray Equipment

    Showing 1–10 of 629

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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