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    v1.0.28
    OpenPayerBilling CodesTemporary CodesHCPCS hcpcs-q4233-surfactant-nudyn-0-5-cc
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    HCPCS Level II Q4233: Surfactor or Nudyn, 0.5 cc

    HCPCS Level II code Q4233 describes a 0.5 cc unit of surfactor or nudyn, a specialized intratracheal surfactant preparation used to treat or prevent neonatal respiratory distress by reducing surface tension in the lungs; the service is a medication administration of a pulmonary surfactant, typically delivered in a neonatal intensive care unit (NICU) or hospital inpatient setting for newborns requiring respiratory support.

    For related coverage guidance, see recent payer policy updates: B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays, Hepatitis Testing (A, B, C, D) Coverage Criteria.

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    Clinical & Coding Specifications

    Clinical Context

    A neonate born at 28 weeks gestation develops respiratory distress within minutes of birth characterized by tachypnea, retractions, and oxygen requirement despite supplemental oxygen and continuous positive airway pressure (CPAP). A chest radiograph demonstrates low lung volumes and diffuse reticulogranular opacities consistent with neonatal respiratory distress syndrome (surfactant deficiency). The neonatology team elects to administer intratracheal surfactant therapy using Q4233 (Surfactor or nudyn, per 0.5 cc) via endotracheal tube after endotracheal intubation in the neonatal intensive care unit (NICU).

    The clinical workflow includes pre-procedure stabilization and monitoring, endotracheal intubation by a neonatal provider, preparation of the surfactant dose based on weight and vial volume, aseptic instillation into the endotracheal tube, brief manual ventilation or positive-pressure ventilation to distribute surfactant, and post-procedure respiratory support and monitoring for changes in oxygenation, ventilation, heart rate, and potential complications (e.g., bradycardia, desaturation). Medication administration documentation includes product name, lot number, volume administered (recorded in 0.5 cc units), route (intratracheal), time, and the performing provider and assisting staff. Billing uses Q4233 units corresponding to the total 0.5 cc increments administered.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    31600Intubation, endotracheal, emergency procedureEndotracheal intubation is commonly performed immediately prior to intratracheal surfactant administration.
    31500Intubation, endotracheal, planned (non-emergency)Used when airway placement is planned in a controlled setting for surfactant delivery.
    94664Demonstration and/or evaluation of patient use of an aerosol generator, nebulizer, metered dose inhaler or IPPB device; initialMay be used for aerosolized respiratory therapies but is not a substitute for intratracheal surfactant; not typically billed with surfactant instillation.
    94010Ventilation assist and management, initiation of pressure or volume preset ventilator for assisted or controlled breathing; hospital inpatient/observationVentilator initiation and management commonly accompany surfactant administration in preterm infants requiring mechanical ventilation.
    94520Continuous positive airway pressure (CPAP) ventilation, initiation and managementCPAP support before or after surfactant therapy when noninvasive respiratory support is used.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    367500000XCertified Registered Nurse Anesthetist(1) A licensed registered nurse with advanced specialty education in anesthesia who, in collaboration with appropriate health care professionals, prov…
    2251P0200XPediatric Physical TherapistA licensed physical therapist, including but not limited to an individual who is a Board Certified Specialist in Pediatric Physical Therapy, who has d…
    246Q00000XPathology Specialist/Technologist(1) An individual educated and trained in clinical chemistry, microbiology or other biological sciences; and in gathering data on the blood, tissues, …
    207RA0001XAdvanced Heart Failure and Transplant Cardiology PhysicianSpecialists in Advanced Heart Failure and Transplant Cardiology would participate in the inpatient and outpatient management of patients with advanced…
    2084F0202XForensic Psychiatry PhysicianForensic Psychiatry is a subspecialty with psychiatric focus on interrelationships with civil, criminal and administrative law, evaluation and special…
    207SG0207XMedical Biochemical GeneticsA medical biochemical geneticist specializes in the diagnosis, evaluation, prevention, and treatment of patients with biochemical genetic disorders, d…
    207RP1001XPulmonary Disease PhysicianAn internist who treats diseases of the lungs and airways. The pulmonologist diagnoses and treats cancer, pneumonia, pleurisy, asthma, occupational an…

    Related ICD-10-CM Codes

    28 rows

    ICD-10-CM CodeDescription
    J21.0Acute bronchiolitis due to respiratory syncytial virus
    J21.1Acute bronchiolitis due to human metapneumovirus
    J21.8Acute bronchiolitis due to other specified organisms
    J21.9Acute bronchiolitis, unspecified
    J80Acute respiratory distress syndrome
    J95.2Acute pulmonary insufficiency following nonthoracic surgery
    J96.00Acute respiratory failure, unspecified whether with hypoxia or hypercapnia
    J96.01Acute respiratory failure with hypoxia
    J96.02Acute respiratory failure with hypercapnia
    J96.90Respiratory failure, unspecified, unspecified whether with hypoxia or hypercapnia

    Showing 1–10 of 28

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    10 rows

    PolicyPayerEffective Date
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Testing for Diagnosis of Active or Latent TuberculosisOscar Health2026-10-01
    Testing for Vector-Borne InfectionsOscar Health2026-10-01
    Coronavirus Testing in the Outpatient SettingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV)blue cross blue shield - louisiana2026-09-15

    Related Codes

    HCPCS-LEVEL-II-Q4139-INJECTABLE-AMNIOMATRIX-BIODMATRIX-1-CC

    HCPCS Q4139: Amniomatrix or Biodmatrix, Injectable, 1 cc

    HCPCS-LEVEL-II-Q4256-AREA-BASED-PROCEDURAL-ADD-ON-PER-SQ-CM

    HCPCS Q4256: MLG-complete Skin Graft Material, Per Sq Cm

    HCPCS-LEVEL-II-Q5132-ADALIMUMAB-AFZB-ABRILADA-10MG-INJECTION

    HCPCS Level II Q5132: Injection, adalimumab-afzb (Abrilada), 10 mg

    HCPCS-Q0035-CARDIOKYMOGRAPHY-CARDIAC-MOTION-RECORDING

    HCPCS Level II Q0035: Cardiokymography

    HCPCS-Q0081-INFUSION-THERAPY-NON-CHEMOTHERAPEUTIC-PER-VISIT

    HCPCS Level II Q0081: Infusion Therapy, Non‑Chemotherapeutic, Per Visit

    HCPCS-Q0083-CHEMOTHERAPY-NON-INFUSION-ADMINISTRATION

    HCPCS Q0083: Chemotherapy Administration, Non-Infusion Methods

    HCPCS-Q0084-CHEMOTHERAPY-INFUSION-ADMINISTRATION-PER-VISIT

    HCPCS Q0084: Chemotherapy Infusion Administration, Per Visit

    HCPCS-Q0085-CHEMOTHERAPY-INFUSION-PLUS-OTHER-TECHNIQUES-PER-VISIT

    HCPCS Q0085: Chemotherapy Infusion Plus Other Technique(s), Per Visit

    HCPCS-Q0091-PAP-SMEAR-SPECIMEN-COLLECTION-TRANSPORT

    HCPCS Q0091: Screening Papanicolaou Smear Collection and Transport

    HCPCS-Q0092-PORTABLE-XRAY-EQUIPMENT-SETUP

    HCPCS Q0092: Set-up Portable X-ray Equipment

    Showing 1–10 of 629

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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