HCPCS Level II Q2056: Ciltacabtagene Autoleucel CAR‑T Therapy

HCPCS Level II code Q2056 describes ciltacabtagene autoleucel administered as a single therapeutic dose of up to 100 million autologous BCMA-directed CAR-positive T cells, and explicitly includes leukapheresis and dose preparation procedures; service type: autologous cellular immunotherapy (CAR-T) infusion/administration; typical site of service: inpatient acute care or hospital outpatient infusion/oncology center settings depending on clinical need and facility capability.

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HCPCS Level II Q2056: Ciltacabtagene Autoleucel CAR‑T Therapy

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Get alerted when payer policies referencing Q2056 are released or updated.

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Clinical & Coding Specifications

Clinical Context

A 62-year-old patient with relapsed/refractory multiple myeloma who has exhausted standard therapies presents for autologous BCMA-directed CAR T-cell therapy using ciltacabtagene autoleucel (Q2056). The multidisciplinary workflow includes hematology/oncology evaluation, eligibility confirmation, informed consent, baseline organ function testing (CBC, CMP, cardiac and pulmonary assessment), infectious disease screening, and collection of peripheral blood mononuclear cells via leukapheresis. Collected cells are sent to manufacturing for CAR transduction and expansion. Prior to lymphodepleting chemotherapy, the patient is admitted or observed in an outpatient infusion center for pre-infusion assessments and eligibility re-check. Lymphodepleting chemotherapy (typically fludarabine and cyclophosphamide) is administered per protocol. On the scheduled day, the thawed autologous CAR T-cell product is prepared and infused under close monitoring for infusion reactions. Post-infusion, the patient is observed for cytokine release syndrome and neurotoxicity with frequent vital signs, laboratory monitoring, and access to tocilizumab and corticosteroids per institutional algorithms. The typical site of service is an inpatient hematology/oncology unit or an outpatient specialized cellular therapy infusion suite within an academic cancer center or accredited cellular therapy program. Billing for the therapeutic dose of ciltacabtagene autoleucel is reported with Q2056, which includes leukapheresis and dose preparation procedures bundled per the HCPCS description.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`36511`	Collection of peripheral blood stem cells for transplantation, per collection; for therapeutic leukapheresis or PBSC collection	Used for the leukapheresis procedure to collect autologous lymphocytes prior to CAR T manufacturing.
`36415`	Collection of venous blood by venipuncture	Used for routine peripheral blood samples for pre-treatment labs and monitoring.
`96365`	Intravenous infusion, therapeutic, prophylactic, or diagnostic; initial, up to 1 hour	Used for administration of lymphodepleting chemotherapy or supportive IV medications prior to infusion.
`96413`	Chemotherapy administration, intravenous infusion technique; each additional hour	Used for multi-hour lymphodepletion infusions when time-based reporting is required.
`99499`	Unlisted evaluation and management service	Occasionally used for institution-specific coordination or complex, non-standard billing encounters related to cellular therapy care coordination.

Related Modifiers

5 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
82	Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…	- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
2084P0800X	Psychiatry Physician	A Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
363L00000X	Nurse Practitioner	(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
261QM3000X	Medically Fragile Infants and Children Day Care	An entity, facility, or distinct part of a facility specially equipped and staffed to provide care for medically fragile children with varied and comp…
3336C0004X	Compounding Pharmacy	A pharmacy that specializes in the preparation of components into a drug preparation as the result of a Practitioner's Prescription Drug Order or init…
207QS0010X	Sports Medicine (Family Medicine) Physician	A family medicine physician that is trained to be responsible for continuous care in the field of sports medicine, not only for the enhancement of hea…
2088F0040X	Urogynecology and Reconstructive Pelvic Surgery (Urology) Physician	A subspecialist in Urogynecology and Reconstructive Pelvic Surgery is a physician in Urology or Obstetrics and Gynecology who, by virtue of education …
275N00000X	Medicare Defined Swing Bed Hospital Unit	A unit of a hospital that has a Medicare provider agreement and has been granted approval from HCFA to provide post-hospital extended care services an…

Related ICD-10-CM Codes

26 rows

ICD-10-CM Code	Description
C81.90	Hodgkin lymphoma, unspecified, unspecified site
C82.90	Follicular lymphoma, unspecified, unspecified site
C83.30	Diffuse large B-cell lymphoma, unspecified site
C84.90	Mature T/NK-cell lymphomas, unspecified, unspecified site
C85.80	Other specified types of non-Hodgkin lymphoma, unspecified site
C85.89	Other specified types of non-Hodgkin lymphoma, extranodal and solid organ sites
C85.90	Non-Hodgkin lymphoma, unspecified, unspecified site
C90.00	Multiple myeloma not having achieved remission
C90.01	Multiple myeloma in remission
C90.02	Multiple myeloma in relapse

Showing 1–10 of 26

HCPCS Q4139: Amniomatrix or Biodmatrix, Injectable, 1 cc

HCPCS-LEVEL-II-Q4256-AREA-BASED-PROCEDURAL-ADD-ON-PER-SQ-CM

HCPCS Q4256: MLG-complete Skin Graft Material, Per Sq Cm

HCPCS-LEVEL-II-Q5132-ADALIMUMAB-AFZB-ABRILADA-10MG-INJECTION

HCPCS Level II Q5132: Injection, adalimumab-afzb (Abrilada), 10 mg

HCPCS-Q0035-CARDIOKYMOGRAPHY-CARDIAC-MOTION-RECORDING

HCPCS Level II Q0035: Cardiokymography

HCPCS-Q0081-INFUSION-THERAPY-NON-CHEMOTHERAPEUTIC-PER-VISIT

HCPCS Level II Q0081: Infusion Therapy, Non‑Chemotherapeutic, Per Visit

HCPCS-Q0083-CHEMOTHERAPY-NON-INFUSION-ADMINISTRATION

HCPCS Q0083: Chemotherapy Administration, Non-Infusion Methods

HCPCS-Q0084-CHEMOTHERAPY-INFUSION-ADMINISTRATION-PER-VISIT

HCPCS Q0084: Chemotherapy Infusion Administration, Per Visit

HCPCS-Q0085-CHEMOTHERAPY-INFUSION-PLUS-OTHER-TECHNIQUES-PER-VISIT

HCPCS Q0085: Chemotherapy Infusion Plus Other Technique(s), Per Visit

HCPCS-Q0091-PAP-SMEAR-SPECIMEN-COLLECTION-TRANSPORT

HCPCS Q0091: Screening Papanicolaou Smear Collection and Transport

HCPCS-Q0092-PORTABLE-XRAY-EQUIPMENT-SETUP

HCPCS Q0092: Set-up Portable X-ray Equipment

Showing 1–10 of 629

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`36511`	Collection of peripheral blood stem cells for transplantation, per collection; for therapeutic leukapheresis or PBSC collection	Used for the leukapheresis procedure to collect autologous lymphocytes prior to CAR T manufacturing.
`36415`	Collection of venous blood by venipuncture	Used for routine peripheral blood samples for pre-treatment labs and monitoring.
`96365`	Intravenous infusion, therapeutic, prophylactic, or diagnostic; initial, up to 1 hour	Used for administration of lymphodepleting chemotherapy or supportive IV medications prior to infusion.
`96413`	Chemotherapy administration, intravenous infusion technique; each additional hour	Used for multi-hour lymphodepletion infusions when time-based reporting is required.
`99499`	Unlisted evaluation and management service	Occasionally used for institution-specific coordination or complex, non-standard billing encounters related to cellular therapy care coordination.

Related Modifiers

5 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
82	Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…	- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
2084P0800X	Psychiatry Physician	A Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
363L00000X	Nurse Practitioner	(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
261QM3000X	Medically Fragile Infants and Children Day Care	An entity, facility, or distinct part of a facility specially equipped and staffed to provide care for medically fragile children with varied and comp…
3336C0004X	Compounding Pharmacy	A pharmacy that specializes in the preparation of components into a drug preparation as the result of a Practitioner's Prescription Drug Order or init…
207QS0010X	Sports Medicine (Family Medicine) Physician	A family medicine physician that is trained to be responsible for continuous care in the field of sports medicine, not only for the enhancement of hea…
2088F0040X	Urogynecology and Reconstructive Pelvic Surgery (Urology) Physician	A subspecialist in Urogynecology and Reconstructive Pelvic Surgery is a physician in Urology or Obstetrics and Gynecology who, by virtue of education …
275N00000X	Medicare Defined Swing Bed Hospital Unit	A unit of a hospital that has a Medicare provider agreement and has been granted approval from HCFA to provide post-hospital extended care services an…

Related ICD-10-CM Codes

26 rows

ICD-10-CM Code	Description
C81.90	Hodgkin lymphoma, unspecified, unspecified site
C82.90	Follicular lymphoma, unspecified, unspecified site
C83.30	Diffuse large B-cell lymphoma, unspecified site
C84.90	Mature T/NK-cell lymphomas, unspecified, unspecified site
C85.80	Other specified types of non-Hodgkin lymphoma, unspecified site
C85.89	Other specified types of non-Hodgkin lymphoma, extranodal and solid organ sites
C85.90	Non-Hodgkin lymphoma, unspecified, unspecified site
C90.00	Multiple myeloma not having achieved remission
C90.01	Multiple myeloma in remission
C90.02	Multiple myeloma in relapse

Showing 1–10 of 26

HCPCS Q4139: Amniomatrix or Biodmatrix, Injectable, 1 cc

HCPCS-LEVEL-II-Q4256-AREA-BASED-PROCEDURAL-ADD-ON-PER-SQ-CM

HCPCS Q4256: MLG-complete Skin Graft Material, Per Sq Cm

HCPCS-LEVEL-II-Q5132-ADALIMUMAB-AFZB-ABRILADA-10MG-INJECTION

HCPCS Level II Q5132: Injection, adalimumab-afzb (Abrilada), 10 mg

HCPCS-Q0035-CARDIOKYMOGRAPHY-CARDIAC-MOTION-RECORDING

HCPCS Level II Q0035: Cardiokymography

HCPCS-Q0081-INFUSION-THERAPY-NON-CHEMOTHERAPEUTIC-PER-VISIT

HCPCS Level II Q0081: Infusion Therapy, Non‑Chemotherapeutic, Per Visit

HCPCS-Q0083-CHEMOTHERAPY-NON-INFUSION-ADMINISTRATION

HCPCS Q0083: Chemotherapy Administration, Non-Infusion Methods

HCPCS-Q0084-CHEMOTHERAPY-INFUSION-ADMINISTRATION-PER-VISIT

HCPCS Q0084: Chemotherapy Infusion Administration, Per Visit

HCPCS-Q0085-CHEMOTHERAPY-INFUSION-PLUS-OTHER-TECHNIQUES-PER-VISIT

HCPCS Q0085: Chemotherapy Infusion Plus Other Technique(s), Per Visit

HCPCS-Q0091-PAP-SMEAR-SPECIMEN-COLLECTION-TRANSPORT

HCPCS Q0091: Screening Papanicolaou Smear Collection and Transport

HCPCS-Q0092-PORTABLE-XRAY-EQUIPMENT-SETUP

HCPCS Q0092: Set-up Portable X-ray Equipment

Showing 1–10 of 629

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

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HCPCS Level II Q2056: Ciltacabtagene Autoleucel CAR‑T Therapy

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HCPCS Level II Q2056: Ciltacabtagene Autoleucel CAR‑T Therapy

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

References

HCPCS Level II Q2056: Ciltacabtagene Autoleucel CAR‑T Therapy

Sign up for hcpcs Q2056 policy alerts

HCPCS Level II Q2056: Ciltacabtagene Autoleucel CAR‑T Therapy

Sign up for hcpcs Q2056 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS code Q2056 cover and where is the therapy typically provided?

Which modifiers might be used with Q2056 and when are they appropriate?

What CPT codes are commonly billed in conjunction with Q2056 and how do they relate?

Which ICD-10 diagnosis codes are referenced as relevant to billing Q2056?

Which payers are listed for Q2056 and what operational billing implications are highlighted?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS code Q2056 cover and where is the therapy typically provided?

Which modifiers might be used with Q2056 and when are they appropriate?

What CPT codes are commonly billed in conjunction with Q2056 and how do they relate?

Which ICD-10 diagnosis codes are referenced as relevant to billing Q2056?

Which payers are listed for Q2056 and what operational billing implications are highlighted?

References