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    OpenPayerBilling CodesTemporary CodesHCPCS hcpcs-q2055-idecabtagene-vicleucel-bcma-car-t-therapy
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    HCPCS Level II Q2055: Idecabtagene vicleucel BCMA-directed CAR T-cell therapy

    HCPCS Level II code Q2055 represents idecabtagene vicleucel administered as a single therapeutic dose of up to 510 million autologous B‑cell maturation antigen (BCMA)–directed CAR‑positive T cells, and the code includes leukapheresis and dose preparation procedures; service type: cellular immunotherapy administration and product delivery; typical site of service: inpatient or outpatient hospital or specialized cellular therapy center where leukapheresis and CAR T cell processing occur.

    For related coverage guidance, see recent payer policy updates: Truvada (Emtricitabine and Tenofovir Disoproxil Fumarate) for HIV Prevention and Treatment, HIV/AIDS Pharmacologic Prevention and Treatment, Long-Acting Injectable Antiretroviral Agents for HIV.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old patient with relapsed, refractory multiple myeloma after at least three prior lines of therapy presents for autologous BCMA-directed CAR T-cell therapy with idecabtagene vicleucel (Q2055). The clinical workflow begins with hematology/oncology evaluation confirming eligibility, baseline organ function testing (CBC, CMP, viral serologies), and performance status assessment. The patient undergoes leukapheresis in an ambulatory apheresis unit or hospital outpatient infusion center to collect peripheral blood mononuclear cells, which are shipped for CAR T manufacturing. Prior to lymphodepleting chemotherapy, the patient receives pre-treatment counseling and consent, and a central venous access plan is finalized.

    On return of the manufactured product, the patient is admitted or scheduled to an inpatient hematology oncology unit or specialized outpatient infusion center for product receipt, dose preparation, and infusion. Lymphodepletion (commonly fludarabine and cyclophosphamide) is administered per protocol, followed by administration of the single therapeutic dose of idecabtagene vicleucel (Q2055). Post-infusion monitoring includes inpatient observation for cytokine release syndrome and neurotoxicity with frequent vital signs, laboratory assessments, and use of tocilizumab or corticosteroids per institutional guidelines if complications occur. Follow-up visits include serial labs, infection prophylaxis management, and disease response assessment at planned intervals.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36511Collection of blood for transfusion, therapeutic apheresis, or stem cell collection; each collectionPerformed during leukapheresis to collect cells for manufacture prior to Q2055 product creation
    38206Therapeutic apheresis, with removal of cellular components; per sessionMay be used for specific apheresis procedures related to collection depending on payer and facility practice
    96401Chemotherapy administration, subcutaneous or intramuscular; non-hormonal, anti-neoplasticMay apply to administration of lymphodepleting agents when billed separately (site-dependent)
    96413Chemotherapy administration, intravenous infusion, up to 1 hourUsed for intravenous lymphodepleting chemotherapy administration prior to CAR T infusion
    36415Collection of venous blood by venipuncturePerformed for baseline and post-infusion laboratory monitoring
    36561Insertion of tunneled centrally inserted central venous catheter, without subcutaneous port or pumpUsed when placement of long-term central venous access is required for therapy or monitoring

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    207LP2900X
    363LA2200X
    363LF0000X
    163WX0002X
    1223D0001X
    364SF0001X
    246ZB0301X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    C83.30Diffuse large B-cell lymphoma, unspecified site
    C85.80Other specified types of non-Hodgkin lymphoma, unspecified site
    C90.00Multiple myeloma not having achieved remission
    C90.01Multiple myeloma in remission
    C90.02Multiple myeloma in relapse
    C90.10Plasma cell leukemia not having achieved remission
    C90.11Plasma cell leukemia in remission
    C90.12Plasma cell leukemia in relapse
    C90.20Extramedullary plasmacytoma not having achieved remission
    C90.21Extramedullary plasmacytoma in remission

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    10 rows

    PolicyPayerEffective Date
    Truvada (Emtricitabine and Tenofovir Disoproxil Fumarate) for HIV Prevention and Treatmentpremerabluecrossofwashington2026-10-01
    HIV/AIDS Pharmacologic Prevention and Treatmentpremerabluecrossofwashington2026-10-01
    Long-Acting Injectable Antiretroviral Agents for HIVColorado Rocky Mountain Health Plans2026-10-01
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Testing for Diagnosis of Active or Latent TuberculosisOscar Health2026-10-01

    Related Codes

    HCPCS-LEVEL-II-Q4139-INJECTABLE-AMNIOMATRIX-BIODMATRIX-1-CC

    HCPCS Q4139: Amniomatrix or Biodmatrix, Injectable, 1 cc

    HCPCS-LEVEL-II-Q4256-AREA-BASED-PROCEDURAL-ADD-ON-PER-SQ-CM

    HCPCS Q4256: MLG-complete Skin Graft Material, Per Sq Cm

    HCPCS-LEVEL-II-Q5132-ADALIMUMAB-AFZB-ABRILADA-10MG-INJECTION

    HCPCS Level II Q5132: Injection, adalimumab-afzb (Abrilada), 10 mg

    HCPCS-Q0035-CARDIOKYMOGRAPHY-CARDIAC-MOTION-RECORDING

    HCPCS Level II Q0035: Cardiokymography

    HCPCS-Q0081-INFUSION-THERAPY-NON-CHEMOTHERAPEUTIC-PER-VISIT

    HCPCS Level II Q0081: Infusion Therapy, Non‑Chemotherapeutic, Per Visit

    HCPCS-Q0083-CHEMOTHERAPY-NON-INFUSION-ADMINISTRATION

    HCPCS Q0083: Chemotherapy Administration, Non-Infusion Methods

    HCPCS-Q0084-CHEMOTHERAPY-INFUSION-ADMINISTRATION-PER-VISIT

    HCPCS Q0084: Chemotherapy Infusion Administration, Per Visit

    HCPCS-Q0085-CHEMOTHERAPY-INFUSION-PLUS-OTHER-TECHNIQUES-PER-VISIT

    HCPCS Q0085: Chemotherapy Infusion Plus Other Technique(s), Per Visit

    HCPCS-Q0091-PAP-SMEAR-SPECIMEN-COLLECTION-TRANSPORT

    HCPCS Q0091: Screening Papanicolaou Smear Collection and Transport

    HCPCS-Q0092-PORTABLE-XRAY-EQUIPMENT-SETUP

    HCPCS Q0092: Set-up Portable X-ray Equipment

    Showing 1–10 of 629

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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