HCPCS Level II Q2049: Doxorubicin Hydrochloride Liposomal Injection, 10 mg

HCPCS Level II code Q2049 represents an injection of doxorubicin hydrochloride, liposomal formulation (imported Lipodox) in a 10 mg presentation; the service is an oncology chemotherapy administration typically provided as an intravenous infusion in an outpatient infusion center or hospital outpatient department for treatment of cancer.

Customize your policy alerts

Sign up for hcpcs Q2049 policy alerts

Get alerted when payer policies referencing Q2049 are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Explore openpayer tools

View all tools

HCPCS Level II Q2049: Doxorubicin Hydrochloride Liposomal Injection, 10 mg

Customize your policy alerts

Sign up for hcpcs Q2049 policy alerts

Get alerted when payer policies referencing Q2049 are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Clinical & Coding Specifications

Clinical Context

A typical patient is an adult with a solid tumor or recurrent epithelial ovarian cancer, metastatic breast cancer, or Kaposi sarcoma receiving intravenous chemotherapy with liposomal doxorubicin (Q2049, 10 mg vial of imported Lipodox). The patient arrives to an outpatient infusion center or hospital outpatient oncology infusion suite for preparation and administration. Pre-infusion workflow includes verification of diagnosis and prior authorization, assessment of performance status, review of current labs (complete blood count, hepatic function tests), and confirmation of vascular access (peripheral IV or central line). Pharmacy compounds the dose per weight or body surface area using aseptic technique and dispenses syringes/vials and infusion tubing. The infusion nurse performs time-out, documents pre-medications if indicated (antiemetic, corticosteroid, H2 blocker), and initiates infusion with monitoring for infusion reactions, extravasation risk, myelosuppression, mucositis, and cardiotoxicity. Post-infusion care includes observation for delayed infusion reactions, disposition instructions, scheduling of follow-up labs and oncology clinic visit, and documentation of administered Q2049 dose, lot number, and route in the medical record and claim form.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96365`	Intravenous infusion, initial, therapeutic, prophylactic, or diagnostic; up to 1 hour	Often billed for the initial continuous infusion period when chemotherapy is administered in the outpatient infusion setting.
`96366`	Intravenous infusion, each additional hour (list separately in addition to code for primary service)	Used when infusion duration exceeds one hour and additional hours are required.
`96413`	Chemotherapy administration, intravenous infusion technique; each additional hour (list separately in addition to code for primary service)	Used as add-on for prolonged IV chemotherapy infusion beyond base chemotherapy administration code.
`96417`	Chemotherapy administration, push technique, up to 30 minutes	Used if liposomal doxorubicin is administered as a short intravenous push per protocol (rare; check protocol).
`96379`	Unlisted infusion procedure (specify)	Used if there is no specific code that describes a unique infusion service or when reporting complex infusion-related procedures not captured by standard codes.

Related Modifiers

5 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
23	Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…	- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RC0000X	Cardiovascular Disease Physician	An internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
363L00000X	Nurse Practitioner	(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
333600000X	Pharmacy	A facility used by pharmacists for the compounding and dispensing of medicinal preparations and other associated professional and administrative servi…
2086S0105X	Surgery of the Hand (Surgery) Physician	A surgeon with expertise in the investigation, preservation and restoration by medical, surgical and rehabilitative means, of all structures of the up…
207VB0002X	Obesity Medicine (Obstetrics & Gynecology) Physician	A physician who specializes in the treatment of obesity demonstrates competency in and a thorough understanding of the treatment of obesity and the ge…
207ND0101X	MOHS-Micrographic Surgery Physician	The highly-trained surgeons that perform Mohs Micrographic Surgery are specialists both in dermatology and pathology. With their extensive knowledge o…
261QS0132X	Ophthalmologic Surgery Clinic/Center	Ambulatory Health Care Facilities · Clinic/Center

Related ICD-10-CM Codes

27 rows

ICD-10-CM Code	Description
C18.9	Malignant neoplasm of colon, unspecified
C20	Malignant neoplasm of rectum
C22.0	Liver cell carcinoma
C25.9	Malignant neoplasm of pancreas, unspecified
C34.11	Malignant neoplasm of upper lobe, right bronchus or lung
C34.90	Malignant neoplasm of unspecified part of unspecified bronchus or lung
C43.9	Malignant melanoma of skin, unspecified
C45.9	Mesothelioma, unspecified
C50.911	Malignant neoplasm of unspecified site of right female breast
C53.9	Malignant neoplasm of cervix uteri, unspecified

Showing 1–10 of 27

Related Payer Policy Updates

Specialty: Infectious Disease1 / 3

10 rows

Policy	Payer	Effective Date
B-Hemolytic Streptococcus Testing	Oscar Health	2026-10-01
Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays	Oscar Health	2026-10-01
Hepatitis Testing (A, B, C, D) Coverage Criteria	Oscar Health	2026-10-01
Pathogen Panel Testing	Oscar Health	2026-10-01
Lyme Disease Testing Coverage Criteria	Oscar Health	2026-10-01
Diagnostic Testing of Common Sexually Transmitted Infections	Oscar Health	2026-10-01
Testing for Diagnosis of Active or Latent Tuberculosis	Oscar Health	2026-10-01
Coronavirus Testing in the Outpatient Setting	Oscar Health	2026-10-01
Testing for Vector-Borne Infections	Oscar Health	2026-10-01
Human Immunodeficiency Virus (HIV)	blue cross blue shield - louisiana	2026-09-15

HCPCS Q4139: Amniomatrix or Biodmatrix, Injectable, 1 cc

HCPCS-LEVEL-II-Q4256-AREA-BASED-PROCEDURAL-ADD-ON-PER-SQ-CM

HCPCS Q4256: MLG-complete Skin Graft Material, Per Sq Cm

HCPCS-LEVEL-II-Q5132-ADALIMUMAB-AFZB-ABRILADA-10MG-INJECTION

HCPCS Level II Q5132: Injection, adalimumab-afzb (Abrilada), 10 mg

HCPCS-Q0035-CARDIOKYMOGRAPHY-CARDIAC-MOTION-RECORDING

HCPCS Level II Q0035: Cardiokymography

HCPCS-Q0081-INFUSION-THERAPY-NON-CHEMOTHERAPEUTIC-PER-VISIT

HCPCS Level II Q0081: Infusion Therapy, Non‑Chemotherapeutic, Per Visit

HCPCS-Q0083-CHEMOTHERAPY-NON-INFUSION-ADMINISTRATION

HCPCS Q0083: Chemotherapy Administration, Non-Infusion Methods

HCPCS-Q0084-CHEMOTHERAPY-INFUSION-ADMINISTRATION-PER-VISIT

HCPCS Q0084: Chemotherapy Infusion Administration, Per Visit

HCPCS-Q0085-CHEMOTHERAPY-INFUSION-PLUS-OTHER-TECHNIQUES-PER-VISIT

HCPCS Q0085: Chemotherapy Infusion Plus Other Technique(s), Per Visit

HCPCS-Q0091-PAP-SMEAR-SPECIMEN-COLLECTION-TRANSPORT

HCPCS Q0091: Screening Papanicolaou Smear Collection and Transport

HCPCS-Q0092-PORTABLE-XRAY-EQUIPMENT-SETUP

HCPCS Q0092: Set-up Portable X-ray Equipment

Showing 1–10 of 629

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Explore openpayer tools

View all tools

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96365`	Intravenous infusion, initial, therapeutic, prophylactic, or diagnostic; up to 1 hour	Often billed for the initial continuous infusion period when chemotherapy is administered in the outpatient infusion setting.
`96366`	Intravenous infusion, each additional hour (list separately in addition to code for primary service)	Used when infusion duration exceeds one hour and additional hours are required.
`96413`	Chemotherapy administration, intravenous infusion technique; each additional hour (list separately in addition to code for primary service)	Used as add-on for prolonged IV chemotherapy infusion beyond base chemotherapy administration code.
`96417`	Chemotherapy administration, push technique, up to 30 minutes	Used if liposomal doxorubicin is administered as a short intravenous push per protocol (rare; check protocol).
`96379`	Unlisted infusion procedure (specify)	Used if there is no specific code that describes a unique infusion service or when reporting complex infusion-related procedures not captured by standard codes.

Related Modifiers

5 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
23	Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…	- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RC0000X	Cardiovascular Disease Physician	An internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
363L00000X	Nurse Practitioner	(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
333600000X	Pharmacy	A facility used by pharmacists for the compounding and dispensing of medicinal preparations and other associated professional and administrative servi…
2086S0105X	Surgery of the Hand (Surgery) Physician	A surgeon with expertise in the investigation, preservation and restoration by medical, surgical and rehabilitative means, of all structures of the up…
207VB0002X	Obesity Medicine (Obstetrics & Gynecology) Physician	A physician who specializes in the treatment of obesity demonstrates competency in and a thorough understanding of the treatment of obesity and the ge…
207ND0101X	MOHS-Micrographic Surgery Physician	The highly-trained surgeons that perform Mohs Micrographic Surgery are specialists both in dermatology and pathology. With their extensive knowledge o…
261QS0132X	Ophthalmologic Surgery Clinic/Center	Ambulatory Health Care Facilities · Clinic/Center

Related ICD-10-CM Codes

27 rows

ICD-10-CM Code	Description
C18.9	Malignant neoplasm of colon, unspecified
C20	Malignant neoplasm of rectum
C22.0	Liver cell carcinoma
C25.9	Malignant neoplasm of pancreas, unspecified
C34.11	Malignant neoplasm of upper lobe, right bronchus or lung
C34.90	Malignant neoplasm of unspecified part of unspecified bronchus or lung
C43.9	Malignant melanoma of skin, unspecified
C45.9	Mesothelioma, unspecified
C50.911	Malignant neoplasm of unspecified site of right female breast
C53.9	Malignant neoplasm of cervix uteri, unspecified

Showing 1–10 of 27

Related Payer Policy Updates

Specialty: Infectious Disease1 / 3

10 rows

Policy	Payer	Effective Date
B-Hemolytic Streptococcus Testing	Oscar Health	2026-10-01
Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays	Oscar Health	2026-10-01
Hepatitis Testing (A, B, C, D) Coverage Criteria	Oscar Health	2026-10-01
Pathogen Panel Testing	Oscar Health	2026-10-01
Lyme Disease Testing Coverage Criteria	Oscar Health	2026-10-01
Diagnostic Testing of Common Sexually Transmitted Infections	Oscar Health	2026-10-01
Testing for Diagnosis of Active or Latent Tuberculosis	Oscar Health	2026-10-01
Coronavirus Testing in the Outpatient Setting	Oscar Health	2026-10-01
Testing for Vector-Borne Infections	Oscar Health	2026-10-01
Human Immunodeficiency Virus (HIV)	blue cross blue shield - louisiana	2026-09-15

HCPCS Q4139: Amniomatrix or Biodmatrix, Injectable, 1 cc

HCPCS-LEVEL-II-Q4256-AREA-BASED-PROCEDURAL-ADD-ON-PER-SQ-CM

HCPCS Q4256: MLG-complete Skin Graft Material, Per Sq Cm

HCPCS-LEVEL-II-Q5132-ADALIMUMAB-AFZB-ABRILADA-10MG-INJECTION

HCPCS Level II Q5132: Injection, adalimumab-afzb (Abrilada), 10 mg

HCPCS-Q0035-CARDIOKYMOGRAPHY-CARDIAC-MOTION-RECORDING

HCPCS Level II Q0035: Cardiokymography

HCPCS-Q0081-INFUSION-THERAPY-NON-CHEMOTHERAPEUTIC-PER-VISIT

HCPCS Level II Q0081: Infusion Therapy, Non‑Chemotherapeutic, Per Visit

HCPCS-Q0083-CHEMOTHERAPY-NON-INFUSION-ADMINISTRATION

HCPCS Q0083: Chemotherapy Administration, Non-Infusion Methods

HCPCS-Q0084-CHEMOTHERAPY-INFUSION-ADMINISTRATION-PER-VISIT

HCPCS Q0084: Chemotherapy Infusion Administration, Per Visit

HCPCS-Q0085-CHEMOTHERAPY-INFUSION-PLUS-OTHER-TECHNIQUES-PER-VISIT

HCPCS Q0085: Chemotherapy Infusion Plus Other Technique(s), Per Visit

HCPCS-Q0091-PAP-SMEAR-SPECIMEN-COLLECTION-TRANSPORT

HCPCS Q0091: Screening Papanicolaou Smear Collection and Transport

HCPCS-Q0092-PORTABLE-XRAY-EQUIPMENT-SETUP

HCPCS Q0092: Set-up Portable X-ray Equipment

Showing 1–10 of 629

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

HCPCS Level II Q2049: Doxorubicin Hydrochloride Liposomal Injection, 10 mg

Sign up for hcpcs Q2049 policy alerts

OpenPayer

HCPCS Level II Q2049: Doxorubicin Hydrochloride Liposomal Injection, 10 mg

Sign up for hcpcs Q2049 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Payer Policy Updates

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Payer Policy Updates

Related Codes

References

HCPCS Level II Q2049: Doxorubicin Hydrochloride Liposomal Injection, 10 mg

Sign up for hcpcs Q2049 policy alerts

HCPCS Level II Q2049: Doxorubicin Hydrochloride Liposomal Injection, 10 mg

Sign up for hcpcs Q2049 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Payer Policy Updates

Related Codes

What does HCPCS code Q2049 represent and where is it typically used?

Which modifiers are commonly applicable to Q2049 and when should they be used?

Which CPT administration codes are commonly billed alongside Q2049?

What clinical documentation elements does the page say are important when administering Lipodox (Q2049)?

Which diagnoses and specialties are associated with Q2049 according to the content?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Payer Policy Updates

Related Codes

What does HCPCS code Q2049 represent and where is it typically used?

Which modifiers are commonly applicable to Q2049 and when should they be used?

Which CPT administration codes are commonly billed alongside Q2049?

What clinical documentation elements does the page say are important when administering Lipodox (Q2049)?

Which diagnoses and specialties are associated with Q2049 according to the content?

References