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    v1.0.28
    OpenPayerBilling CodesTemporary CodesHCPCS hcpcs-q0164-prochlorperazine-oral-anti-emetic-chemo-substitute
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    HCPCS Q0164: Prochlorperazine 5 mg Oral Anti‑emetic for Chemotherapy

    HCPCS Level II code Q0164 identifies prochlorperazine maleate 5 mg, oral, FDA-approved as a prescription anti-emetic used as a complete therapeutic substitute for an IV anti-emetic at the time of chemotherapy treatment; service type: oral anti-emetic medication provided as a chemotherapy adjunct for prevention or treatment of nausea/vomiting; typical site of service: oncology infusion centers, outpatient oncology clinics, or other settings where chemotherapy is administered.

    For related coverage guidance, see recent payer policy updates: B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays, Hepatitis Testing (A, B, C, D) Coverage Criteria.

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    Clinical & Coding Specifications

    Clinical Context

    A patient receiving outpatient chemotherapy for solid tumor malignancy experiences nausea and vomiting risk around infusion time. The oncology nurse documents that the patient has a history of severe chemotherapy-induced nausea and cannot receive or declines an IV anti-emetic during the infusion. The prescriber orders an FDA‑approved oral prochlorperazine maleate regimen, Q0164 (prochlorperazine maleate, 5 mg, oral), to be administered as a complete therapeutic substitute for an IV anti-emetic, with dosing limited to a 48‑hour regimen. The medication is dispensed by the infusion center pharmacy or clinic dispenser and administered or given to the patient at the time of chemotherapy when IV administration is not feasible or contraindicated. Typical workflow steps: prescriber documents indication and rationale for oral substitute in the medical record; pharmacist verifies dosing and dispense limits; nurse documents administration or patient receipt of the package and monitors for efficacy and adverse effects during the 48‑hour window. Billing is submitted using Q0164 with an appropriate modifier reflecting the service circumstance and the patient’s insurer rules.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96413Chemotherapy administration, IV infusion technique; each additional sequential infusion (typically 1 hour or more)Often billed for the IV chemotherapy administration at the same visit when Q0164 is used as an oral substitute for an IV anti‑emetic; documents the infusion service.
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularMay be billed for supportive injections given during the same visit (e.g., supportive agents) alongside the oral anti‑emetic.
    99213Office or other outpatient visit for the evaluation and management of an established patient, typically 15 minutesUsed when the prescriber documents assessment and orders Q0164 during a clinic visit associated with chemotherapy.
    96417Chemotherapy administration, push technique, each additional substance/drug administeredUse when other IV push medications are administered during the chemotherapy session in conjunction with the oral anti‑emetic substitution.
    99070Supplies and materials (e.g., drugs, appliances) provided by the physician over and above those usually included in the serviceMay be used by some payers to report separately provided oral anti‑emetic supplies when payer policy permits.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    103TS0200XSchool PsychologistA psychologist whose specialty is concerned with the science and practice of psychology with children, youth, families; learners of all ages; and the …
    2081S0010XSports Medicine (Physical Medicine & Rehabilitation) PhysicianA physician who specializes in Sports Medicine is responsible for continuous care related to the enhancement of health and fitness as well as the prev…
    163WL0100XLactation Consultant (Registered Nurse)Nursing Service Providers · Registered Nurse
    311Z00000XCustodial Care FacilityA facility providing care that serves to assist an individual in the activities of daily living, such as assistance in walking, getting in and out of …
    246QI0000XImmunology Pathology Specialist/TechnologistTechnologists, Technicians & Other Technical Service Providers · Specialist/Technologist, Pathology

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    9 rows

    PolicyPayerEffective Date
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Coronavirus Testing in the Outpatient SettingOscar Health2026-10-01
    Testing for Diagnosis of Active or Latent TuberculosisOscar Health2026-10-01
    Testing for Vector-Borne InfectionsOscar Health2026-10-01

    Related Codes

    HCPCS-LEVEL-II-Q4139-INJECTABLE-AMNIOMATRIX-BIODMATRIX-1-CC

    HCPCS Q4139: Amniomatrix or Biodmatrix, Injectable, 1 cc

    HCPCS-LEVEL-II-Q4256-AREA-BASED-PROCEDURAL-ADD-ON-PER-SQ-CM

    HCPCS Q4256: MLG-complete Skin Graft Material, Per Sq Cm

    HCPCS-LEVEL-II-Q5132-ADALIMUMAB-AFZB-ABRILADA-10MG-INJECTION

    HCPCS Level II Q5132: Injection, adalimumab-afzb (Abrilada), 10 mg

    HCPCS-Q0035-CARDIOKYMOGRAPHY-CARDIAC-MOTION-RECORDING

    HCPCS Level II Q0035: Cardiokymography

    HCPCS-Q0081-INFUSION-THERAPY-NON-CHEMOTHERAPEUTIC-PER-VISIT

    HCPCS Level II Q0081: Infusion Therapy, Non‑Chemotherapeutic, Per Visit

    HCPCS-Q0083-CHEMOTHERAPY-NON-INFUSION-ADMINISTRATION

    HCPCS Q0083: Chemotherapy Administration, Non-Infusion Methods

    HCPCS-Q0084-CHEMOTHERAPY-INFUSION-ADMINISTRATION-PER-VISIT

    HCPCS Q0084: Chemotherapy Infusion Administration, Per Visit

    HCPCS-Q0085-CHEMOTHERAPY-INFUSION-PLUS-OTHER-TECHNIQUES-PER-VISIT

    HCPCS Q0085: Chemotherapy Infusion Plus Other Technique(s), Per Visit

    HCPCS-Q0091-PAP-SMEAR-SPECIMEN-COLLECTION-TRANSPORT

    HCPCS Q0091: Screening Papanicolaou Smear Collection and Transport

    HCPCS-Q0092-PORTABLE-XRAY-EQUIPMENT-SETUP

    HCPCS Q0092: Set-up Portable X-ray Equipment

    Showing 1–10 of 629

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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