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    v1.0.28
    OpenPayerBilling CodesTemporary CodesHCPCS hcpcs-q0144-azithromycin-1g-oral
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    HCPCS Level II Q0144: Azithromycin dihydrate oral 1 gram

    HCPCS Level II code Q0144 represents azithromycin dihydrate, oral formulation supplied as capsules or powder totaling 1 gram, used for outpatient oral antibiotic therapy; the service is the dispensing/supply of a single-dose oral macrolide antibiotic and the typical site of service is outpatient pharmacy or clinic-based dispensing for ambulatory patients.

    For related coverage guidance, see recent payer policy updates: B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays, Hepatitis Testing (A, B, C, D) Coverage Criteria.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult presenting to an urgent care clinic or outpatient primary care office with symptoms of acute bacterial infection such as suspected sexually transmitted infection (e.g., chlamydia), community-acquired otitis media, or certain soft tissue infections where a single-dose oral macrolide is appropriate. The clinician performs a focused history and physical, documents the indication and any allergies, and may obtain point-of-care testing (e.g., NAAT for chlamydia/gonorrhea) or cultures as indicated. When a single 1 gram oral dose of azithromycin is selected, the medication is dispensed or administered in-office with documentation of the lot number, route (oral), and dosing. For billing, the product is reported with HCPCS Level II code Q0144 for azithromycin dihydrate, oral, capsules/powder, 1 gram. Common payer interactions include verifying coverage for pharmacy-dispensed versus in-office supplied medication and appending an appropriate modifier when billing circumstances require it (for example, modifier 25 if a significant, separately identifiable evaluation and management service was provided the same day). Typical sites of service are outpatient clinic, urgent care, emergency department, or community sexual health clinics where single‑dose oral therapy is delivered.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    99202Office or other outpatient visit for the evaluation and management of a new patient, straightforward medical decision makingMay be billed the same day when a new patient evaluation leads to prescribing Q0144; append 25 if a distinct E/M is documented.
    99213Office or other outpatient visit for the evaluation and management of an established patient, low to moderate complexityCommonly performed for follow-up or for evaluation and prescription of single‑dose azithromycin in established patients.
    87801Infectious agent detection by nucleic acid (e.g., NAAT)Often ordered in the workup for sexually transmitted infections prior to or at the time of dispensing Q0144 for chlamydial infection.
    87070Culture, bacterial; any other source, except urine, blood or stool, aerobic, with isolation and presumptive identification of isolatesMay be obtained when bacterial infection is suspected and guides antibiotic choice including azithromycin.
    99070Supplies and materials (e.g., drugs administration)Used when billing for non-covered supplies or items provided in the office; payer policies differ for drug supply versus pharmacy billing of Q0144.
    96372Therapeutic, prophylactic, or diagnostic injection (specify subcutaneous or intramuscular)Not directly for oral medication but included when injectable alternatives are used in related clinical workflows.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    2086S0122XPlastic and Reconstructive Surgery PhysicianA surgeon who specializes in plastic and reconstructive surgery.
    2080S0012XPediatric Sleep Medicine PhysicianA Pediatrician who practices Sleep Medicine is certified in the subspecialty of sleep medicine and specializes in the clinical assessment, physiologic…
    164X00000XLicensed Vocational NurseAn individual with post-high school vocational training and practical experience in the provision of nursing care at a level less than that required f…
    207VC0200XCritical Care Medicine (Obstetrics & Gynecology) PhysicianAn obstetrician/gynecologist, who specializes in critical care medicine diagnoses, treats and supports female patients with multiple organ dysfunction…

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    A03.9Shigellosis, unspecified
    A41.9Sepsis, unspecified organism
    A49.1Streptococcal infection, unspecified site
    A54.00Gonococcal infection of lower genitourinary tract, unspecified
    A54.03Gonococcal cervicitis, unspecified
    A56.00Chlamydial infection of lower genitourinary tract, unspecified
    B95.5Unspecified streptococcus as the cause of diseases classified elsewhere
    H66.90Otitis media, unspecified, unspecified ear
    J00Acute nasopharyngitis [common cold]
    J01.90Acute sinusitis, unspecified

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    9 rows

    PolicyPayerEffective Date
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Testing for Vector-Borne InfectionsOscar Health2026-10-01
    Coronavirus Testing in the Outpatient SettingOscar Health2026-10-01
    Testing for Diagnosis of Active or Latent TuberculosisOscar Health2026-10-01

    Related Codes

    HCPCS-LEVEL-II-Q4139-INJECTABLE-AMNIOMATRIX-BIODMATRIX-1-CC

    HCPCS Q4139: Amniomatrix or Biodmatrix, Injectable, 1 cc

    HCPCS-LEVEL-II-Q4256-AREA-BASED-PROCEDURAL-ADD-ON-PER-SQ-CM

    HCPCS Q4256: MLG-complete Skin Graft Material, Per Sq Cm

    HCPCS-LEVEL-II-Q5132-ADALIMUMAB-AFZB-ABRILADA-10MG-INJECTION

    HCPCS Level II Q5132: Injection, adalimumab-afzb (Abrilada), 10 mg

    HCPCS-Q0035-CARDIOKYMOGRAPHY-CARDIAC-MOTION-RECORDING

    HCPCS Level II Q0035: Cardiokymography

    HCPCS-Q0081-INFUSION-THERAPY-NON-CHEMOTHERAPEUTIC-PER-VISIT

    HCPCS Level II Q0081: Infusion Therapy, Non‑Chemotherapeutic, Per Visit

    HCPCS-Q0083-CHEMOTHERAPY-NON-INFUSION-ADMINISTRATION

    HCPCS Q0083: Chemotherapy Administration, Non-Infusion Methods

    HCPCS-Q0084-CHEMOTHERAPY-INFUSION-ADMINISTRATION-PER-VISIT

    HCPCS Q0084: Chemotherapy Infusion Administration, Per Visit

    HCPCS-Q0085-CHEMOTHERAPY-INFUSION-PLUS-OTHER-TECHNIQUES-PER-VISIT

    HCPCS Q0085: Chemotherapy Infusion Plus Other Technique(s), Per Visit

    HCPCS-Q0091-PAP-SMEAR-SPECIMEN-COLLECTION-TRANSPORT

    HCPCS Q0091: Screening Papanicolaou Smear Collection and Transport

    HCPCS-Q0092-PORTABLE-XRAY-EQUIPMENT-SETUP

    HCPCS Q0092: Set-up Portable X-ray Equipment

    Showing 1–10 of 629

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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