HCPCS Level II J9076: Cyclophosphamide Injection, 5 mg (Baxter)

HCPCS Level II code J9076 describes an injection of cyclophosphamide (Baxter), 5 mg, used as an antineoplastic/chemotherapy agent; the service is administration of an intravenous chemotherapy drug (medication supply) typically provided in oncology infusion centers or hospital outpatient infusion settings and documented as a drug administration line item on outpatient medical claims.

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HCPCS Level II J9076: Cyclophosphamide Injection, 5 mg (Baxter)

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Get alerted when payer policies referencing J9076 are released or updated.

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Clinical & Coding Specifications

Clinical Context

A 62-year-old female with relapsed non-Hodgkin lymphoma is scheduled for outpatient intravenous chemotherapy with single-agent cyclophosphamide (Baxter) for cytoreduction prior to combination therapy. The patient arrives to the oncology infusion clinic, is triaged by a registered nurse, vital signs documented, and pre-medication orders reviewed. The oncologist confirms indication, dosage calculated by body surface area, and pharmacy prepares the J9076 drug vial(s) in a sterile compounding area. The infusion nurse verifies identity, allergy history, and chemotherapy consent, administers an antiemetic per protocol, and gives the cyclophosphamide via IV push or short infusion as ordered. Post-administration monitoring includes observation for infusion reactions, assessment of nausea, and documentation of the administered amount in milligrams and vial count. Billing is submitted using J9076 reported per 5 mg unit with applicable modifiers to reflect service details (e.g., billing for drug wastage, split/shared services, professional component) and facility taxonomy codes for the treating provider type. Typical site of service is an oncology infusion center or outpatient hospital infusion department.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96365`	Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hour	May be used when cyclophosphamide is administered as an infusion requiring timed infusion reporting.
`96366`	Intravenous infusion, each additional hour	Use for extended infusion time beyond the initial hour when clinically indicated.
`96413`	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug	Commonly billed for chemotherapy infusion services when administration requires infusion technique and monitoring.
`96415`	Chemotherapy administration, each additional hour	Used for additional infusion time associated with chemotherapy beyond the initial hour.
`96417`	Chemotherapy administration under continuous infusion, per hour	Used when cyclophosphamide is administered as part of a continuous infusion protocol.
`90772`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	May be used if adjunctive supportive injections (e.g., antiemetics, growth factors) are given during the same encounter.

Related Modifiers

5 rows

Modifier	Description	When to Use
23	Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…	- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
66	Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…	- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RC0000X	Cardiovascular Disease Physician	An internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
207P00000X	Emergency Medicine Physician	An emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
253J00000X	Foster Care Agency	A Foster Care Agency is an agency that provides foster care as defined in the Code of Federal Regulations (CFR) as "24-hour substitute care for childr…
3416A0800X	Air Ambulance	Transportation Services · Ambulance
332B00000X	Durable Medical Equipment & Medical Supplies	A supplier of medical equipment such as respirators, wheelchairs, home dialysis systems, or monitoring systems, that are prescribed by a physician for…
207RC0001X	Clinical Cardiac Electrophysiology Physician	A field of special interest within the subspecialty of cardiovascular disease, specialty of Internal Medicine, which involves intricate technical proc…

Related ICD-10-CM Codes

27 rows

ICD-10-CM Code	Description
C18.9	Malignant neoplasm of colon, unspecified
C20	Malignant neoplasm of rectum
C22.0	Liver cell carcinoma
C33	Malignant neoplasm of trachea
C34.90	Malignant neoplasm of unspecified part of unspecified bronchus or lung
C50.911	Malignant neoplasm of unspecified site of right female breast
C61	Malignant neoplasm of prostate
C67.9	Malignant neoplasm of bladder, unspecified
C71.9	Malignant neoplasm of brain, unspecified
C81.90	Hodgkin lymphoma, unspecified, unspecified site

Showing 1–10 of 27

Related Codes

HCPCS-J9000-DOXORUBICIN-10MG-INJECTION

HCPCS J9000: Doxorubicin Hydrochloride Injection, 10 mg

HCPCS-J9003-LEUPROLIDE-INJECTABLE-CAMCEVI-1MG

HCPCS Level II J9003: Leuprolide injectable (camcevi etm), 1 mg

HCPCS-J9010-ALEMTUZUMAB-INJECTION-10MG

HCPCS Level II J9010: Injection, alemtuzumab, 10 mg

HCPCS-J9011-DATOPOTAMAB-DERUXTECAN-INJECTION-1MG

HCPCS J9011: Datopotamab Deruxtecan Injection, 1 mg

HCPCS-J9015-ALDESLEUKIN-INJECTION-SINGLE-USE-VIAL

HCPCS Level II J9015: Aldesleukin Injection, Single-Use Vial

HCPCS-J9017-ARSENIC-TRIOXIDE-INJECTION-1MG

HCPCS J9017: Arsenic Trioxide Injection, 1 mg

HCPCS-J9019-ASPARAGINASE-ERWINAZE-INJECTION-1000-IU

HCPCS Level II J9019: Asparaginase (Erwinaze) Injection, 1,000 IU

HCPCS-J9020-ASPARAGINASE-INJECTION-10000-UNITS

HCPCS J9020: Asparaginase Injection, 10,000 Units

HCPCS-J9021-ASPARAGINASE-RYLAZE-INJECTION-0-1-MG

HCPCS Level II J9021: Injection, asparaginase (Rylaze), 0.1 mg

HCPCS-J9022-ATEZOLIZUMAB-INJECTION-10MG

HCPCS J9022: Injection, atezolizumab 10 mg

Showing 1–10 of 227

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96365`	Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hour	May be used when cyclophosphamide is administered as an infusion requiring timed infusion reporting.
`96366`	Intravenous infusion, each additional hour	Use for extended infusion time beyond the initial hour when clinically indicated.
`96413`	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug	Commonly billed for chemotherapy infusion services when administration requires infusion technique and monitoring.
`96415`	Chemotherapy administration, each additional hour	Used for additional infusion time associated with chemotherapy beyond the initial hour.
`96417`	Chemotherapy administration under continuous infusion, per hour	Used when cyclophosphamide is administered as part of a continuous infusion protocol.
`90772`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	May be used if adjunctive supportive injections (e.g., antiemetics, growth factors) are given during the same encounter.

Related Modifiers

5 rows

Modifier	Description	When to Use
23	Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…	- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
66	Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…	- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RC0000X	Cardiovascular Disease Physician	An internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
207P00000X	Emergency Medicine Physician	An emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
253J00000X	Foster Care Agency	A Foster Care Agency is an agency that provides foster care as defined in the Code of Federal Regulations (CFR) as "24-hour substitute care for childr…
3416A0800X	Air Ambulance	Transportation Services · Ambulance
332B00000X	Durable Medical Equipment & Medical Supplies	A supplier of medical equipment such as respirators, wheelchairs, home dialysis systems, or monitoring systems, that are prescribed by a physician for…
207RC0001X	Clinical Cardiac Electrophysiology Physician	A field of special interest within the subspecialty of cardiovascular disease, specialty of Internal Medicine, which involves intricate technical proc…

Related ICD-10-CM Codes

27 rows

ICD-10-CM Code	Description
C18.9	Malignant neoplasm of colon, unspecified
C20	Malignant neoplasm of rectum
C22.0	Liver cell carcinoma
C33	Malignant neoplasm of trachea
C34.90	Malignant neoplasm of unspecified part of unspecified bronchus or lung
C50.911	Malignant neoplasm of unspecified site of right female breast
C61	Malignant neoplasm of prostate
C67.9	Malignant neoplasm of bladder, unspecified
C71.9	Malignant neoplasm of brain, unspecified
C81.90	Hodgkin lymphoma, unspecified, unspecified site

Showing 1–10 of 27

Related Codes

HCPCS-J9000-DOXORUBICIN-10MG-INJECTION

HCPCS J9000: Doxorubicin Hydrochloride Injection, 10 mg

HCPCS-J9003-LEUPROLIDE-INJECTABLE-CAMCEVI-1MG

HCPCS Level II J9003: Leuprolide injectable (camcevi etm), 1 mg

HCPCS-J9010-ALEMTUZUMAB-INJECTION-10MG

HCPCS Level II J9010: Injection, alemtuzumab, 10 mg

HCPCS-J9011-DATOPOTAMAB-DERUXTECAN-INJECTION-1MG

HCPCS J9011: Datopotamab Deruxtecan Injection, 1 mg

HCPCS-J9015-ALDESLEUKIN-INJECTION-SINGLE-USE-VIAL

HCPCS Level II J9015: Aldesleukin Injection, Single-Use Vial

HCPCS-J9017-ARSENIC-TRIOXIDE-INJECTION-1MG

HCPCS J9017: Arsenic Trioxide Injection, 1 mg

HCPCS-J9019-ASPARAGINASE-ERWINAZE-INJECTION-1000-IU

HCPCS Level II J9019: Asparaginase (Erwinaze) Injection, 1,000 IU

HCPCS-J9020-ASPARAGINASE-INJECTION-10000-UNITS

HCPCS J9020: Asparaginase Injection, 10,000 Units

HCPCS-J9021-ASPARAGINASE-RYLAZE-INJECTION-0-1-MG

HCPCS Level II J9021: Injection, asparaginase (Rylaze), 0.1 mg

HCPCS-J9022-ATEZOLIZUMAB-INJECTION-10MG

HCPCS J9022: Injection, atezolizumab 10 mg

Showing 1–10 of 227

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

HCPCS Level II J9076: Cyclophosphamide Injection, 5 mg (Baxter)

Sign up for hcpcs J9076 policy alerts

HCPCS Level II J9076: Cyclophosphamide Injection, 5 mg (Baxter)

Sign up for hcpcs J9076 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS code J9076 represent and where is it typically used?

When should modifiers JW or JZ be used with J9076?

Which CPT codes are commonly reported with J9076 for administration services?

What clinical and documentation steps are described that relate to billing J9076?

Which provider taxonomy codes are listed as relevant for services involving J9076?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS code J9076 represent and where is it typically used?

When should modifiers JW or JZ be used with J9076?

Which CPT codes are commonly reported with J9076 for administration services?

What clinical and documentation steps are described that relate to billing J9076?

Which provider taxonomy codes are listed as relevant for services involving J9076?

References