HCPCS Level II J9021: Injection, asparaginase (Rylaze), 0.1 mg

HCPCS Level II code J9021 describes administration of recombinant asparaginase (Rylaze) measured per 0.1 mg, representing a parenteral chemotherapy or biologic injection typically billed for inpatient or outpatient oncology settings such as hospital infusion centers or clinic infusion suites; this code is used to report the specific drug product and unit-of-measure for clinical documentation and claims processing.

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HCPCS Level II J9021: Injection, asparaginase (Rylaze), 0.1 mg

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Clinical & Coding Specifications

Clinical Context

A pediatric or young adult patient with acute lymphoblastic leukemia (ALL) receiving systemic chemotherapy in an outpatient infusion center or inpatient oncology ward. The patient is scheduled to receive recombinant asparaginase (J9021, 0.1 mg units) as part of an induction or consolidation chemotherapy regimen. Typical workflow: review of oncology orders and recent labs (including hepatic panel, coagulation studies, and serum asparagine if available), assessment for prior hypersensitivity to asparaginase products, verification of venous access (peripheral IV or central line), preparation of the reconstituted product by pharmacy, administration by an oncology nurse with appropriate monitoring for hypersensitivity reactions and pancreatitis, documentation of lot number and expiration, and billing using J9021 with any applicable modifier (for example JW for discarded drug or QK/QX for pharmacist/qualified person services). Typical site of service: outpatient hospital infusion center, physician office oncology clinic, or inpatient hospital floor depending on clinical status. Typical patient scenario: a 10-year-old child on day 8 of induction presenting to the pediatric oncology infusion unit for scheduled asparaginase dosing; baseline labs reviewed and within acceptable ranges, no prior anaphylaxis, dose prepared by pharmacy and administered via peripheral IV with 60 minutes of observation post-infusion for immediate reactions.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96413`	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug	Commonly billed for the initial IV infusion session when `J9021` is administered as the primary chemotherapeutic agent during a visit.
`96415`	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary infusion)	Used when infusion of `J9021` and concurrent agents requires infusion time beyond the first hour.
`96401`	Chemotherapy administration, subcutaneous or intramuscular; non-hormonal antineoplastic	Used if `J9021` is administered intramuscularly or subcutaneously per specific protocol (less common for recombinant asparaginase formulations).
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	May be used for a single injection administration when protocol or payer requires this code for non-IV routes.
`36415`	Collection of venous blood by venipuncture	Performed prior to `J9021` administration for baseline labs (liver enzymes, coagulation, amylase/lipase).
`99070`	Supplies and materials (e.g., syringes, needles), non-covered by the service	May be used to bill for non-covered administration supplies associated with `J9021` when allowed by payer.

Related Modifiers

5 rows

Modifier	Description	When to Use
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
2084P0800X	Psychiatry Physician	A Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
363L00000X	Nurse Practitioner	(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
3336C0002X	Clinic Pharmacy	A pharmacy in a clinic, emergency room or hospital (outpatient) that dispenses medications to patients for self-administration under the supervision o…
367500000X	Certified Registered Nurse Anesthetist	(1) A licensed registered nurse with advanced specialty education in anesthesia who, in collaboration with appropriate health care professionals, prov…
332000000X	Military/U.S. Coast Guard Pharmacy	A Department of Defense (DoD) or U.S. Coast Guard entity whose primary function is to store, prepare and dispense pharmaceuticals and other associated…
226000000X	Recreational Therapist Assistant	Recreational Therapist Assistants work in support of or assistant to Recreational Therapists treating patients with disabilities, injuries, and illnes…
246YC3301X	Hospital Based Coding Specialist	None

Related ICD-10-CM Codes

30 rows

ICD-10-CM Code	Description
C91.00	Acute lymphoblastic leukemia not having achieved remission
C91.01	Acute lymphoblastic leukemia, in remission
C91.02	Acute lymphoblastic leukemia, in relapse
C91.10	Chronic lymphocytic leukemia of B-cell type not having achieved remission
C91.11	Chronic lymphocytic leukemia of B-cell type in remission
C91.12	Chronic lymphocytic leukemia of B-cell type in relapse
C91.30	Prolymphocytic leukemia of B-cell type not having achieved remission
C91.31	Prolymphocytic leukemia of B-cell type, in remission
C91.32	Prolymphocytic leukemia of B-cell type, in relapse
C91.40	Hairy cell leukemia not having achieved remission

Showing 1–10 of 30

Related Codes

HCPCS-J9000-DOXORUBICIN-10MG-INJECTION

HCPCS J9000: Doxorubicin Hydrochloride Injection, 10 mg

HCPCS-J9003-LEUPROLIDE-INJECTABLE-CAMCEVI-1MG

HCPCS Level II J9003: Leuprolide injectable (camcevi etm), 1 mg

HCPCS-J9010-ALEMTUZUMAB-INJECTION-10MG

HCPCS Level II J9010: Injection, alemtuzumab, 10 mg

HCPCS-J9011-DATOPOTAMAB-DERUXTECAN-INJECTION-1MG

HCPCS J9011: Datopotamab Deruxtecan Injection, 1 mg

HCPCS-J9015-ALDESLEUKIN-INJECTION-SINGLE-USE-VIAL

HCPCS Level II J9015: Aldesleukin Injection, Single-Use Vial

HCPCS-J9017-ARSENIC-TRIOXIDE-INJECTION-1MG

HCPCS J9017: Arsenic Trioxide Injection, 1 mg

HCPCS-J9019-ASPARAGINASE-ERWINAZE-INJECTION-1000-IU

HCPCS Level II J9019: Asparaginase (Erwinaze) Injection, 1,000 IU

HCPCS-J9020-ASPARAGINASE-INJECTION-10000-UNITS

HCPCS J9020: Asparaginase Injection, 10,000 Units

HCPCS-J9022-ATEZOLIZUMAB-INJECTION-10MG

HCPCS J9022: Injection, atezolizumab 10 mg

HCPCS-J9023-AVELUMAB-10MG-INJECTION

HCPCS J9023: Avelumab Injection, 10 mg

Showing 1–10 of 227

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96413`	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug	Commonly billed for the initial IV infusion session when `J9021` is administered as the primary chemotherapeutic agent during a visit.
`96415`	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary infusion)	Used when infusion of `J9021` and concurrent agents requires infusion time beyond the first hour.
`96401`	Chemotherapy administration, subcutaneous or intramuscular; non-hormonal antineoplastic	Used if `J9021` is administered intramuscularly or subcutaneously per specific protocol (less common for recombinant asparaginase formulations).
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	May be used for a single injection administration when protocol or payer requires this code for non-IV routes.
`36415`	Collection of venous blood by venipuncture	Performed prior to `J9021` administration for baseline labs (liver enzymes, coagulation, amylase/lipase).
`99070`	Supplies and materials (e.g., syringes, needles), non-covered by the service	May be used to bill for non-covered administration supplies associated with `J9021` when allowed by payer.

Related Modifiers

5 rows

Modifier	Description	When to Use
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
2084P0800X	Psychiatry Physician	A Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
363L00000X	Nurse Practitioner	(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
3336C0002X	Clinic Pharmacy	A pharmacy in a clinic, emergency room or hospital (outpatient) that dispenses medications to patients for self-administration under the supervision o…
367500000X	Certified Registered Nurse Anesthetist	(1) A licensed registered nurse with advanced specialty education in anesthesia who, in collaboration with appropriate health care professionals, prov…
332000000X	Military/U.S. Coast Guard Pharmacy	A Department of Defense (DoD) or U.S. Coast Guard entity whose primary function is to store, prepare and dispense pharmaceuticals and other associated…
226000000X	Recreational Therapist Assistant	Recreational Therapist Assistants work in support of or assistant to Recreational Therapists treating patients with disabilities, injuries, and illnes…
246YC3301X	Hospital Based Coding Specialist	None

Related ICD-10-CM Codes

30 rows

ICD-10-CM Code	Description
C91.00	Acute lymphoblastic leukemia not having achieved remission
C91.01	Acute lymphoblastic leukemia, in remission
C91.02	Acute lymphoblastic leukemia, in relapse
C91.10	Chronic lymphocytic leukemia of B-cell type not having achieved remission
C91.11	Chronic lymphocytic leukemia of B-cell type in remission
C91.12	Chronic lymphocytic leukemia of B-cell type in relapse
C91.30	Prolymphocytic leukemia of B-cell type not having achieved remission
C91.31	Prolymphocytic leukemia of B-cell type, in remission
C91.32	Prolymphocytic leukemia of B-cell type, in relapse
C91.40	Hairy cell leukemia not having achieved remission

Showing 1–10 of 30

Related Codes

HCPCS-J9000-DOXORUBICIN-10MG-INJECTION

HCPCS J9000: Doxorubicin Hydrochloride Injection, 10 mg

HCPCS-J9003-LEUPROLIDE-INJECTABLE-CAMCEVI-1MG

HCPCS Level II J9003: Leuprolide injectable (camcevi etm), 1 mg

HCPCS-J9010-ALEMTUZUMAB-INJECTION-10MG

HCPCS Level II J9010: Injection, alemtuzumab, 10 mg

HCPCS-J9011-DATOPOTAMAB-DERUXTECAN-INJECTION-1MG

HCPCS J9011: Datopotamab Deruxtecan Injection, 1 mg

HCPCS-J9015-ALDESLEUKIN-INJECTION-SINGLE-USE-VIAL

HCPCS Level II J9015: Aldesleukin Injection, Single-Use Vial

HCPCS-J9017-ARSENIC-TRIOXIDE-INJECTION-1MG

HCPCS J9017: Arsenic Trioxide Injection, 1 mg

HCPCS-J9019-ASPARAGINASE-ERWINAZE-INJECTION-1000-IU

HCPCS Level II J9019: Asparaginase (Erwinaze) Injection, 1,000 IU

HCPCS-J9020-ASPARAGINASE-INJECTION-10000-UNITS

HCPCS J9020: Asparaginase Injection, 10,000 Units

HCPCS-J9022-ATEZOLIZUMAB-INJECTION-10MG

HCPCS J9022: Injection, atezolizumab 10 mg

HCPCS-J9023-AVELUMAB-10MG-INJECTION

HCPCS J9023: Avelumab Injection, 10 mg

Showing 1–10 of 227

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

HCPCS Level II J9021: Injection, asparaginase (Rylaze), 0.1 mg

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HCPCS Level II J9021: Injection, asparaginase (Rylaze), 0.1 mg

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS J9021 represent and how is it measured?

In which sites of service and clinical workflow scenarios is J9021 commonly used?

Which CPT administration codes are commonly billed with J9021?

What pre-administration assessments and monitoring are described for patients receiving J9021?

Which diagnosis codes are associated with billing J9021 on the claim?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS J9021 represent and how is it measured?

In which sites of service and clinical workflow scenarios is J9021 commonly used?

Which CPT administration codes are commonly billed with J9021?

What pre-administration assessments and monitoring are described for patients receiving J9021?

Which diagnosis codes are associated with billing J9021 on the claim?

References