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    v1.0.30
    OpenPayerBilling CodesChemotherapy DrugsHCPCS hcpcs-j9021-asparaginase-rylaze-injection-0-1-mg
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    HCPCS Level II J9021: Injection, asparaginase (Rylaze), 0.1 mg

    HCPCS Level II code J9021 describes administration of recombinant asparaginase (Rylaze) measured per 0.1 mg, representing a parenteral chemotherapy or biologic injection typically billed for inpatient or outpatient oncology settings such as hospital infusion centers or clinic infusion suites; this code is used to report the specific drug product and unit-of-measure for clinical documentation and claims processing.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A pediatric or young adult patient with acute lymphoblastic leukemia (ALL) receiving systemic chemotherapy in an outpatient infusion center or inpatient oncology ward. The patient is scheduled to receive recombinant asparaginase (J9021, 0.1 mg units) as part of an induction or consolidation chemotherapy regimen. Typical workflow: review of oncology orders and recent labs (including hepatic panel, coagulation studies, and serum asparagine if available), assessment for prior hypersensitivity to asparaginase products, verification of venous access (peripheral IV or central line), preparation of the reconstituted product by pharmacy, administration by an oncology nurse with appropriate monitoring for hypersensitivity reactions and pancreatitis, documentation of lot number and expiration, and billing using J9021 with any applicable modifier (for example JW for discarded drug or QK/QX for pharmacist/qualified person services). Typical site of service: outpatient hospital infusion center, physician office oncology clinic, or inpatient hospital floor depending on clinical status. Typical patient scenario: a 10-year-old child on day 8 of induction presenting to the pediatric oncology infusion unit for scheduled asparaginase dosing; baseline labs reviewed and within acceptable ranges, no prior anaphylaxis, dose prepared by pharmacy and administered via peripheral IV with 60 minutes of observation post-infusion for immediate reactions.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96413Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drugCommonly billed for the initial IV infusion session when J9021 is administered as the primary chemotherapeutic agent during a visit.
    96415Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary infusion)Used when infusion of J9021 and concurrent agents requires infusion time beyond the first hour.
    96401Chemotherapy administration, subcutaneous or intramuscular; non-hormonal antineoplasticUsed if J9021 is administered intramuscularly or subcutaneously per specific protocol (less common for recombinant asparaginase formulations).
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularMay be used for a single injection administration when protocol or payer requires this code for non-IV routes.
    36415Collection of venous blood by venipuncture

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    2084P0800X
    363L00000X
    3336C0002X
    367500000X
    332000000X
    226000000X
    246YC3301X

    Related ICD-10-CM Codes

    30 rows

    ICD-10-CM CodeDescription
    C91.00Acute lymphoblastic leukemia not having achieved remission
    C91.01Acute lymphoblastic leukemia, in remission
    C91.02Acute lymphoblastic leukemia, in relapse
    C91.10Chronic lymphocytic leukemia of B-cell type not having achieved remission
    C91.11Chronic lymphocytic leukemia of B-cell type in remission
    C91.12Chronic lymphocytic leukemia of B-cell type in relapse
    C91.30Prolymphocytic leukemia of B-cell type not having achieved remission
    C91.31Prolymphocytic leukemia of B-cell type, in remission
    C91.32Prolymphocytic leukemia of B-cell type, in relapse
    C91.40Hairy cell leukemia not having achieved remission

    Showing 1–10 of 30

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    HCPCS-J9000-DOXORUBICIN-10MG-INJECTION

    HCPCS J9000: Doxorubicin Hydrochloride Injection, 10 mg

    HCPCS-J9003-LEUPROLIDE-INJECTABLE-CAMCEVI-1MG

    HCPCS Level II J9003: Leuprolide injectable (camcevi etm), 1 mg

    HCPCS-J9010-ALEMTUZUMAB-INJECTION-10MG

    HCPCS Level II J9010: Injection, alemtuzumab, 10 mg

    HCPCS-J9011-DATOPOTAMAB-DERUXTECAN-INJECTION-1MG

    HCPCS J9011: Datopotamab Deruxtecan Injection, 1 mg

    HCPCS-J9015-ALDESLEUKIN-INJECTION-SINGLE-USE-VIAL

    HCPCS Level II J9015: Aldesleukin Injection, Single-Use Vial

    HCPCS-J9017-ARSENIC-TRIOXIDE-INJECTION-1MG

    HCPCS J9017: Arsenic Trioxide Injection, 1 mg

    HCPCS-J9019-ASPARAGINASE-ERWINAZE-INJECTION-1000-IU

    HCPCS Level II J9019: Asparaginase (Erwinaze) Injection, 1,000 IU

    HCPCS-J9020-ASPARAGINASE-INJECTION-10000-UNITS

    HCPCS J9020: Asparaginase Injection, 10,000 Units

    HCPCS-J9022-ATEZOLIZUMAB-INJECTION-10MG

    HCPCS J9022: Injection, atezolizumab 10 mg

    HCPCS-J9023-AVELUMAB-10MG-INJECTION

    HCPCS J9023: Avelumab Injection, 10 mg

    Showing 1–10 of 227

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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    Performed prior to J9021 administration for baseline labs (liver enzymes, coagulation, amylase/lipase).
    99070Supplies and materials (e.g., syringes, needles), non-covered by the serviceMay be used to bill for non-covered administration supplies associated with J9021 when allowed by payer.