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    v1.0.28
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j7665-mannitol-inhalation-5mg
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    HCPCS Level II J7665: Mannitol Inhalation, 5 mg

    HCPCS Level II code J7665 represents mannitol administered via inhaler, 5 mg unit for inhalation therapy; the service is a nebulized/inhalation medication administration typically provided in outpatient clinics, pulmonary function labs, or hospital outpatient departments when inhaled osmotic agents are used for respiratory diagnostic or therapeutic purposes.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only).

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    Table of contents

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    • Billing CodesCPT, HCPCS, DRG & more
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    Clinical & Coding Specifications

    Clinical Context

    A typical adult patient with suspected exercise-induced bronchoconstriction or intermittent asthma presents to a pulmonary function testing or allergy clinic for bronchial challenge testing using inhaled mannitol. The patient history includes episodic wheeze, cough, or chest tightness triggered by exercise or environmental exposures. After baseline spirometry is performed, the clinician administers incremental doses of J7665 (Mannitol, administered through an inhaler, 5 mg) via a standardized dry powder inhaler protocol to provoke airway hyperresponsiveness. Spirometry is repeated after each dose to measure forced expiratory volume in one second (FEV1). The test is stopped when FEV1 falls by the predetermined threshold (commonly ≥10–15%) or the maximum cumulative dose is reached. The procedure typically occurs in an outpatient pulmonary function laboratory, allergy clinic, or hospital outpatient department staffed by a respiratory therapist or pulmonary function technologist under pulmonologist or allergist supervision. Emergency medications and rescue bronchodilators are immediately available; post-test monitoring continues until the patient returns to baseline respiratory status.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    94070Bronchial provocation studies (eg, methacholine, exercise, cold air challenge); non-specific bronchoprovocationDirectly related; used for reporting bronchial challenge testing and may be used in conjunction with inhaled mannitol testing when reporting provocation studies.
    94060Bronchospasm evaluation; spirometry as part of bronchodilator responseUsed before and after mannitol administration to document baseline lung function and response to challenge.
    94640Pressurized or nonpressurized inhalation treatment for acute airway obstruction or for sputum induction for diagnostic purposesUsed if bronchospasm occurs during testing and inhalation treatment (bronchodilator) is administered as rescue therapy.
    94620Pulmonary stress testing of respiratory function (eg, exercise), with ventilatory and gas exchange measurementsMay be performed in related workups for exercise-induced bronchoconstriction when exercise challenge is part of the diagnostic pathway.
    94729Carbon dioxide measurement for measurement of exhaled gases; single determinationMay be used in specialized pulmonary function labs assessing gas exchange during challenge testing.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    364S00000XClinical Nurse SpecialistA registered nurse who, through a graduate degree program in nursing, or through a formal post-basic education program or continuing education courses…
    163WG0600XGerontology Registered NurseNursing Service Providers · Registered Nurse
    136A00000XRegistered Dietetic TechnicianA Dietetic Technician, Registered (DTR)/Nutrition and Dietetics Technician, Registered (NDTR) is an individual holding a nationally protected title is…
    207RT0003XTransplant Hepatology PhysicianAn internist with special knowledge and the skill required of a gastroenterologist to care for patients prior to and following hepatic transplantation…
    364SE1400XEthics Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
    207R00000XInternal Medicine PhysicianA physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
    209800000XLegal Medicine (M.D./D.O.) PhysicianLegal Medicine is a special field of medicine that focuses on various aspects of medicine and law. Historically, the practice of legal medicine made c…
    1835P0200XPediatric PharmacistA licensed pharmacist who has demonstrated specialized knowledge and skill in the delivery of patient care services by pharmacists that ensures the sa…

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    B97.89Other viral agents as the cause of diseases classified elsewhere
    J18.9Pneumonia, unspecified organism
    J20.9Acute bronchitis, unspecified
    J21.9Acute bronchiolitis, unspecified
    J22Unspecified acute lower respiratory infection
    J44.0Chronic obstructive pulmonary disease with (acute) lower respiratory infection
    J44.1Chronic obstructive pulmonary disease with (acute) exacerbation
    J44.9Chronic obstructive pulmonary disease, unspecified
    J45.20Mild intermittent asthma, uncomplicated
    J45.21Mild intermittent asthma with (acute) exacerbation

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Chimeric Antigen Receptor (CAR) T-Cell TherapyColorado Rocky Mountain Health Plans2026-08-01
    Allogeneic Hematopoietic Progenitor Cell TherapyAmbetter Georgia2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Idaho Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for New Jersey Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Ohio Only)UnitedHealthcare2026-08-01
    Reblozyl (luspatercept-aamt) Medical Benefit Drug PolicyUnitedHealthcare2026-08-01

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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