HCPCS Level II J7643: Glycopyrrolate Inhalation Solution, Compounded

HCPCS Level II code J7643 identifies a compounded glycopyrrolate inhalation solution supplied in unit-dose form and billed per milligram; this code represents a pharmacy-administered inhalation medication product typically provided through durable medical equipment (DME) suppliers or outpatient infusion/pharmacy settings and used for inhalation therapy when a standard manufactured formulation is not available.

For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Antibody-Drug Conjugates, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only).

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HCPCS Level II J7643: Glycopyrrolate Inhalation Solution, Compounded

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Get alerted when payer policies referencing J7643 are released or updated.

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Clinical & Coding Specifications

Clinical Context

A typical patient is an adult with chronic obstructive pulmonary disease (COPD) or chronic bronchitis who requires inhaled anticholinergic bronchodilator therapy delivered via a device supplied as durable medical equipment (DME). The patient presents to a pulmonary clinic or home health infusion/respiratory therapy service where a pharmacist compounds unit-dose glycopyrrolate inhalation solution per the prescribing orders. The clinical workflow: the pulmonologist documents the indication and dose in the medical record and sends the prescription to the pharmacy; the pharmacy compounds the unit-dose product in milligram strength and labels it for administration through the patient’s DME nebulizer; respiratory therapy or home health staff verify device compatibility, perform initial patient education on nebulizer use and inhalation technique, and document administration or supply for home use. Billing uses HCPCS Level II code J7643 reported per milligram for the compounded unit-dose product; supplies, DME rental or purchase, and professional services may be billed separately using appropriate DME and service codes. Patient follow-up includes assessment of symptom control, inhalation technique, device maintenance, and adverse effects such as dry mouth or urinary retention.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`94640`	Pressurized or non-pressurized inhalation treatment for acute airway obstruction, nebulizer administration	Used when a nebulized bronchodilator (including compounded solutions) is administered in-clinic for acute bronchodilator therapy.
`94664`	Demonstration and/or evaluation of patient utilization of an aerosol generator, nebulizer, metered dose inhaler or IPPB device	Performed when respiratory therapy provides education and confirms correct nebulizer technique for use with the compounded unit-dose solution.
`99152`	Moderate sedation services provided by the same physician performing a procedure (initial 15 minutes)	Rarely applicable; included only when moderate sedation is medically necessary for administration in complex hospitalized patients (use per payer rules).
`99070`	Supplies and materials (except spectacles), non-covered items; used when additional supplies for nebulizer administration are supplied by the clinic	Billed when clinic-provided disposables or tubing beyond the medication are charged separately.
`A4282`	Nebulizer, with compressed air or ultrasonic nebulizer, nebulizer kit	Commonly billed as DME supply when a new nebulizer device or kit is furnished alongside the compounded unit-dose medication.

Related Modifiers

5 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
P5	Modifier P5 denotes a moribund patient who is not expected to survive without the operative procedure and is used only with anesthesia CPT codes 00100–01999. The anesthesia provider must append P5…	- Use modifier P5 only when the anesthesia provider determines the patient is moribund and not expected to survive without the operation, and append it only to anesthesia CPT codes 00100–01999…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RP1001X	Pulmonary Disease Physician	An internist who treats diseases of the lungs and airways. The pulmonologist diagnoses and treats cancer, pneumonia, pleurisy, asthma, occupational an…
3336C0002X	Clinic Pharmacy	A pharmacy in a clinic, emergency room or hospital (outpatient) that dispenses medications to patients for self-administration under the supervision o…
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
235Z00000X	Speech-Language Pathologist	The speech-language pathologist is the professional who engages in clinical services, prevention, advocacy, education, administration, and research in…
2080C0008X	Child Abuse Pediatrics Physician	A Child Abuse Pediatrician serves as a resource to children, families and communities by accurately diagnosing abuse; consulting with community agenci…

Related Payer Policy Updates

Specialty: Hematology/Oncology1 / 3

10 rows

Policy	Payer	Effective Date
Epithelial Cell Cytology in Breast Cancer Risk Assessment	Oscar Health	2026-10-01
Antibody-Drug Conjugates	Premera Bluecross	2026-08-01
Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)	UnitedHealthcare	2026-08-01
Chimeric Antigen Receptor (CAR) T-Cell Therapy	Colorado Rocky Mountain Health Plans	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)	UnitedHealthcare	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for Idaho Only)	UnitedHealthcare	2026-08-01
Allogeneic Hematopoietic Progenitor Cell Therapy	Ambetter Georgia	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for New Jersey Only)	UnitedHealthcare	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for Ohio Only)	UnitedHealthcare	2026-08-01
Intraperitoneal Chemotherapy (HIPEC/IPHC and PIPAC)	priority health	2026-08-01

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`94640`	Pressurized or non-pressurized inhalation treatment for acute airway obstruction, nebulizer administration	Used when a nebulized bronchodilator (including compounded solutions) is administered in-clinic for acute bronchodilator therapy.
`94664`	Demonstration and/or evaluation of patient utilization of an aerosol generator, nebulizer, metered dose inhaler or IPPB device	Performed when respiratory therapy provides education and confirms correct nebulizer technique for use with the compounded unit-dose solution.
`99152`	Moderate sedation services provided by the same physician performing a procedure (initial 15 minutes)	Rarely applicable; included only when moderate sedation is medically necessary for administration in complex hospitalized patients (use per payer rules).
`99070`	Supplies and materials (except spectacles), non-covered items; used when additional supplies for nebulizer administration are supplied by the clinic	Billed when clinic-provided disposables or tubing beyond the medication are charged separately.
`A4282`	Nebulizer, with compressed air or ultrasonic nebulizer, nebulizer kit	Commonly billed as DME supply when a new nebulizer device or kit is furnished alongside the compounded unit-dose medication.

Related Modifiers

5 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
P5	Modifier P5 denotes a moribund patient who is not expected to survive without the operative procedure and is used only with anesthesia CPT codes 00100–01999. The anesthesia provider must append P5…	- Use modifier P5 only when the anesthesia provider determines the patient is moribund and not expected to survive without the operation, and append it only to anesthesia CPT codes 00100–01999…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RP1001X	Pulmonary Disease Physician	An internist who treats diseases of the lungs and airways. The pulmonologist diagnoses and treats cancer, pneumonia, pleurisy, asthma, occupational an…
3336C0002X	Clinic Pharmacy	A pharmacy in a clinic, emergency room or hospital (outpatient) that dispenses medications to patients for self-administration under the supervision o…
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
235Z00000X	Speech-Language Pathologist	The speech-language pathologist is the professional who engages in clinical services, prevention, advocacy, education, administration, and research in…
2080C0008X	Child Abuse Pediatrics Physician	A Child Abuse Pediatrician serves as a resource to children, families and communities by accurately diagnosing abuse; consulting with community agenci…

Related Payer Policy Updates

Specialty: Hematology/Oncology1 / 3

10 rows

Policy	Payer	Effective Date
Epithelial Cell Cytology in Breast Cancer Risk Assessment	Oscar Health	2026-10-01
Antibody-Drug Conjugates	Premera Bluecross	2026-08-01
Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)	UnitedHealthcare	2026-08-01
Chimeric Antigen Receptor (CAR) T-Cell Therapy	Colorado Rocky Mountain Health Plans	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)	UnitedHealthcare	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for Idaho Only)	UnitedHealthcare	2026-08-01
Allogeneic Hematopoietic Progenitor Cell Therapy	Ambetter Georgia	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for New Jersey Only)	UnitedHealthcare	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for Ohio Only)	UnitedHealthcare	2026-08-01
Intraperitoneal Chemotherapy (HIPEC/IPHC and PIPAC)	priority health	2026-08-01

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

HCPCS Level II J7643: Glycopyrrolate Inhalation Solution, Compounded

Sign up for hcpcs J7643 policy alerts

HCPCS Level II J7643: Glycopyrrolate Inhalation Solution, Compounded

Sign up for hcpcs J7643 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Payer Policy Updates

Related Codes

What does HCPCS code J7643 represent?

How is J7643 billed and can additional items be billed separately?

Which CPT and DME/service codes are commonly used alongside J7643?

In what clinical scenarios and workflow is J7643 typically used?

Which diagnoses are commonly associated with billing J7643?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Payer Policy Updates

Related Codes

What does HCPCS code J7643 represent?

How is J7643 billed and can additional items be billed separately?

Which CPT and DME/service codes are commonly used alongside J7643?

In what clinical scenarios and workflow is J7643 typically used?

Which diagnoses are commonly associated with billing J7643?

References