HCPCS Level II J7189: Factor VIIa (NovoSeven RT), 1 microgram

HCPCS Level II code J7189 describes administration of Factor VIIa (antihemophilic factor, recombinant), (NovoSeven RT) measured per 1 microgram, typically used for hemostatic therapy in patients with bleeding disorders; the service type is recombinant coagulation factor infusion/administration and the typical site of service is hospital outpatient infusion centers or inpatient hospital settings where intravenous biologic factor replacement is provided.

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HCPCS Level II J7189: Factor VIIa (NovoSeven RT), 1 microgram

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Clinical & Coding Specifications

Clinical Context

A 45-year-old male with acquired hemophilia A presents to the emergency department with spontaneous soft tissue bleeding and a prolonged activated partial thromboplastin time (aPTT). The hematology team orders hemostatic therapy with recombinant activated factor VII, J7189 (Novoseven RT) dosed in microgram increments per weight and bleeding severity. The clinical workflow includes intravenous preparation by pharmacy, verification of dose and lot, bedside administration by an RN in the ED or inpatient unit, vital sign monitoring during and after infusion, documentation of dose administered in the medication administration record, and follow-up hematology orders for laboratory monitoring (bleeding control, hemoglobin/hematocrit) and repeat dosing as clinically indicated. Typical sites of service include the emergency department, inpatient hospital ward, intensive care unit, and outpatient infusion centers for refractory bleeding or perioperative hemostasis in at-risk patients.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96365`	Intravenous infusion, therapeutic, prophylactic, or diagnostic; initial, up to 1 hour	Used when `J7189` is administered as an initial IV infusion during an encounter requiring documentation of infusion time.
`96366`	Intravenous infusion, each additional hour (List separately in addition to code for primary infusion)	Used when infusion of hemostatic therapy or supportive IV fluids continues beyond the initial hour.
`36415`	Collection of venous blood by venipuncture	Performed for laboratory monitoring (hemoglobin, coagulation studies) before and after administration of `J7189`.
`99285`	Emergency department visit, high severity	Common ED evaluation complexity when patients present with major bleeding requiring `J7189`.
`99223`	Initial hospital care, typically 70 minutes or more	Used for initial inpatient evaluation of complex bleeding requiring hemostatic therapy and coordination of care.

Related Modifiers

5 rows

Modifier	Description	When to Use
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
76	Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…	- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
82	Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…	- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
363L00000X	Nurse Practitioner	(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
3336C0003X	Community/Retail Pharmacy	A pharmacy where pharmacists store, prepare, and dispense medicinal preparations and/or prescriptions for a local patient population in accordance wit…
367A00000X	Advanced Practice Midwife	Advanced practice midwifery encompasses the independent provision of care during pregnancy, childbirth, and the postpartum period; sexual and reproduc…
213ES0131X	Foot Surgery Podiatrist	Podiatric Medicine & Surgery Service Providers · Podiatrist
224ZF0002X	Feeding, Eating & Swallowing Occupational Therapy Assistant	Occupational therapy assistants provide environmental modifications under the supervision of an occupational therapist. OTAs develop and implement an…
3104A0625X	Assisted Living Facility (Mental Illness)	A facility providing supportive services to individuals who can function independently in most areas of activity, but need special guidance, assistanc…

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96365`	Intravenous infusion, therapeutic, prophylactic, or diagnostic; initial, up to 1 hour	Used when `J7189` is administered as an initial IV infusion during an encounter requiring documentation of infusion time.
`96366`	Intravenous infusion, each additional hour (List separately in addition to code for primary infusion)	Used when infusion of hemostatic therapy or supportive IV fluids continues beyond the initial hour.
`36415`	Collection of venous blood by venipuncture	Performed for laboratory monitoring (hemoglobin, coagulation studies) before and after administration of `J7189`.
`99285`	Emergency department visit, high severity	Common ED evaluation complexity when patients present with major bleeding requiring `J7189`.
`99223`	Initial hospital care, typically 70 minutes or more	Used for initial inpatient evaluation of complex bleeding requiring hemostatic therapy and coordination of care.

Related Modifiers

5 rows

Modifier	Description	When to Use
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
76	Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…	- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
82	Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…	- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
363L00000X	Nurse Practitioner	(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
3336C0003X	Community/Retail Pharmacy	A pharmacy where pharmacists store, prepare, and dispense medicinal preparations and/or prescriptions for a local patient population in accordance wit…
367A00000X	Advanced Practice Midwife	Advanced practice midwifery encompasses the independent provision of care during pregnancy, childbirth, and the postpartum period; sexual and reproduc…
213ES0131X	Foot Surgery Podiatrist	Podiatric Medicine & Surgery Service Providers · Podiatrist
224ZF0002X	Feeding, Eating & Swallowing Occupational Therapy Assistant	Occupational therapy assistants provide environmental modifications under the supervision of an occupational therapist. OTAs develop and implement an…
3104A0625X	Assisted Living Facility (Mental Illness)	A facility providing supportive services to individuals who can function independently in most areas of activity, but need special guidance, assistanc…

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

HCPCS Level II J7189: Factor VIIa (NovoSeven RT), 1 microgram

Sign up for hcpcs J7189 policy alerts

HCPCS Level II J7189: Factor VIIa (NovoSeven RT), 1 microgram

Sign up for hcpcs J7189 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does HCPCS J7189 represent and where is it typically administered?

Which modifiers are commonly used with J7189 and when should they be considered?

Which CPT codes are commonly billed alongside J7189 administration?

What diagnoses are relevant when documenting the medical necessity for J7189?

Which payers are referenced in this analysis and does the page provide reimbursement rates?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does HCPCS J7189 represent and where is it typically administered?

Which modifiers are commonly used with J7189 and when should they be considered?

Which CPT codes are commonly billed alongside J7189 administration?

What diagnoses are relevant when documenting the medical necessity for J7189?

Which payers are referenced in this analysis and does the page provide reimbursement rates?

References