HCPCS Level II J7171: Injection, recombinant ADAMTS13, 10 IU

HCPCS Level II code J7171 describes an injection of recombinant ADAMTS13 (adamts13, recombinant-krhn) dosed per 10 IU, used for replacement of the ADAMTS13 protease; the service is an injectable biologic therapy typically administered as an outpatient infusion or injection in an infusion center, hospital outpatient department, or specialty clinic for management of severe ADAMTS13 deficiency-related conditions.

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HCPCS Level II J7171: Injection, recombinant ADAMTS13, 10 IU

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Get alerted when payer policies referencing J7171 are released or updated.

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Clinical & Coding Specifications

Clinical Context

A typical patient is an adult admitted to an inpatient hematology or tertiary care medical center with acquired thrombotic thrombocytopenic purpura (aTTP) confirmed by severe ADAMTS13 deficiency and presence of ADAMTS13 autoantibodies. The patient presents with microangiopathic hemolytic anemia, thrombocytopenia, and organ ischemia (eg, neurologic symptoms, renal dysfunction). Initial management includes plasma exchange and immunosuppression (corticosteroids, rituximab). Recombinant ADAMTS13 (J7171) is administered as an intravenous injection in measured international units to restore ADAMTS13 activity when available under approved indications or investigational protocols.

Care pathway and workflow:

Admission to inpatient unit or specialty infusion center for acute aTTP or for scheduled replacement/maintenance dosing.
Baseline documentation: diagnosis codes, baseline labs (CBC, LDH, creatinine, haptoglobin), ADAMTS13 activity and inhibitor testing, consent for therapy if required.
Pharmacy preparation and verification of J7171 dose (10 IU vials or multiples) and shelf‑handling per manufacturer guidance.
Administration by trained infusion nurse under hematology oversight. Typical site of service is inpatient hospital, observation unit, or hospital-based infusion center. Dosing frequency and duration are determined by treating hematologist and protocol.
Monitoring during and after injection for infusion reactions, hemolysis parameters, platelet recovery, and organ function. Documentation includes lot number, units administered, route (intravenous), and any applicable modifier (eg, wasted product reported with JW).
Subsequent billing: report J7171 with appropriate modifier(s) to indicate single/multiple vials, product wastage, services related to inpatient status, or circumstances such as reduced services or discontinued administration.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`36415`	Collection of venous blood by venipuncture	Used for baseline and monitoring labs (CBC, hemolysis markers, ADAMTS13 testing) before or after `J7171` administration.

36561 | Insertion of non-tunneled centrally inserted central venous catheter (eg, for plasmapheresis) | Performed when central access is required for concurrent plasma exchange or frequent infusions in severe aTTP patients.

36514 | Collection of blood from catheter, percutaneous, initial tubing change | Used when drawing labs through central venous access associated with inpatient infusion therapy.

36215 | Selective catheter placement, arterial, for diagnostic angiography | Used only if diagnostic angiography is needed for organ ischemia evaluation related to thrombotic events; included as an adjunct procedure in complex cases.

96413 | Chemotherapy administration, intravenous infusion technique, up to 1 hour | Used when payer requires reporting an infusion/IV drug administration code for biologics given by infusion and time-based reporting is appropriate.

Related Modifiers

5 rows

Modifier	Description	When to Use
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
92	Modifier 92 (Alternative Laboratory Platform Testing) is used when laboratory tests are performed with single‑use, disposable, portable kits or transportable instruments. The AMA defines it for tests…	- Use modifier 92 when a laboratory test is performed using a single‑use, disposable analytical device or kit (an alternative laboratory platform) that is portable and may be taken to or near the…
99	Modifier 99 is a placeholder modifier used when more modifiers apply to a single procedure than the claim form or electronic field allows. The AMA classifies it under Provider Services and Ambulatory…	- Use CPT modifier -99 when more modifiers apply to a single procedure line than the claim form or payer field allows (CMS/Noridian: when more than four modifiers are needed); append modifier 99 on…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
2080P0207X	Pediatric Hematology & Oncology Physician	A pediatrician trained in the combination of pediatrics, hematology and oncology to recognize and manage pediatric blood disorders and cancerous disea…
163W00000X	Registered Nurse	(1) A registered nurse is a person qualified by graduation from an accredited nursing school (depending upon schooling, a registered nurse may receive…
363L00000X	Nurse Practitioner	(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
163WP0808X	Psychiatric/Mental Health Registered Nurse	Nursing Service Providers · Registered Nurse
170100000X	Ph.D. Medical Genetics	A medical geneticist works in association with a medical specialist, is affiliated with a clinical genetics program, and serves as a consultant to med…
261QR0404X	Cardiac Rehabilitation Clinic/Center	Ambulatory Health Care Facilities · Clinic/Center
2080P0202X	Pediatric Cardiology Physician	A pediatric cardiologist provides comprehensive care to patients with cardiovascular problems. This specialist is skilled in selecting, performing and…

Related ICD-10-CM Codes

24 rows

ICD-10-CM Code	Description
D59.9	Acquired hemolytic anemia, unspecified
D62	Acute posthemorrhagic anemia
D68.1	Hereditary factor XI deficiency
D68.4	Acquired coagulation factor deficiency
D68.52	Prothrombin gene mutation
D68.9	Coagulation defect, unspecified
D69.0	Allergic purpura
D69.2	Other nonthrombocytopenic purpura
D69.3	Immune thrombocytopenic purpura
D69.49	Other primary thrombocytopenia

Showing 1–10 of 24

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Care pathway and workflow:

Admission to inpatient unit or specialty infusion center for acute aTTP or for scheduled replacement/maintenance dosing.
Baseline documentation: diagnosis codes, baseline labs (CBC, LDH, creatinine, haptoglobin), ADAMTS13 activity and inhibitor testing, consent for therapy if required.
Pharmacy preparation and verification of J7171 dose (10 IU vials or multiples) and shelf‑handling per manufacturer guidance.
Administration by trained infusion nurse under hematology oversight. Typical site of service is inpatient hospital, observation unit, or hospital-based infusion center. Dosing frequency and duration are determined by treating hematologist and protocol.
Monitoring during and after injection for infusion reactions, hemolysis parameters, platelet recovery, and organ function. Documentation includes lot number, units administered, route (intravenous), and any applicable modifier (eg, wasted product reported with JW).
Subsequent billing: report J7171 with appropriate modifier(s) to indicate single/multiple vials, product wastage, services related to inpatient status, or circumstances such as reduced services or discontinued administration.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`36415`	Collection of venous blood by venipuncture	Used for baseline and monitoring labs (CBC, hemolysis markers, ADAMTS13 testing) before or after `J7171` administration.

36514 | Collection of blood from catheter, percutaneous, initial tubing change | Used when drawing labs through central venous access associated with inpatient infusion therapy.

Related Modifiers

5 rows

Modifier	Description	When to Use
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
92	Modifier 92 (Alternative Laboratory Platform Testing) is used when laboratory tests are performed with single‑use, disposable, portable kits or transportable instruments. The AMA defines it for tests…	- Use modifier 92 when a laboratory test is performed using a single‑use, disposable analytical device or kit (an alternative laboratory platform) that is portable and may be taken to or near the…
99	Modifier 99 is a placeholder modifier used when more modifiers apply to a single procedure than the claim form or electronic field allows. The AMA classifies it under Provider Services and Ambulatory…	- Use CPT modifier -99 when more modifiers apply to a single procedure line than the claim form or payer field allows (CMS/Noridian: when more than four modifiers are needed); append modifier 99 on…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
2080P0207X	Pediatric Hematology & Oncology Physician	A pediatrician trained in the combination of pediatrics, hematology and oncology to recognize and manage pediatric blood disorders and cancerous disea…
163W00000X	Registered Nurse	(1) A registered nurse is a person qualified by graduation from an accredited nursing school (depending upon schooling, a registered nurse may receive…
363L00000X	Nurse Practitioner	(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
163WP0808X	Psychiatric/Mental Health Registered Nurse	Nursing Service Providers · Registered Nurse
170100000X	Ph.D. Medical Genetics	A medical geneticist works in association with a medical specialist, is affiliated with a clinical genetics program, and serves as a consultant to med…
261QR0404X	Cardiac Rehabilitation Clinic/Center	Ambulatory Health Care Facilities · Clinic/Center
2080P0202X	Pediatric Cardiology Physician	A pediatric cardiologist provides comprehensive care to patients with cardiovascular problems. This specialist is skilled in selecting, performing and…

Related ICD-10-CM Codes

24 rows

ICD-10-CM Code	Description
D59.9	Acquired hemolytic anemia, unspecified
D62	Acute posthemorrhagic anemia
D68.1	Hereditary factor XI deficiency
D68.4	Acquired coagulation factor deficiency
D68.52	Prothrombin gene mutation
D68.9	Coagulation defect, unspecified
D69.0	Allergic purpura
D69.2	Other nonthrombocytopenic purpura
D69.3	Immune thrombocytopenic purpura
D69.49	Other primary thrombocytopenia

Showing 1–10 of 24

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

HCPCS Level II J7171: Injection, recombinant ADAMTS13, 10 IU

Sign up for hcpcs J7171 policy alerts

HCPCS Level II J7171: Injection, recombinant ADAMTS13, 10 IU

Sign up for hcpcs J7171 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS code J7171 represent and where is it typically administered?

What clinical and billing documentation elements are recommended when reporting J7171?

Which CPT codes are commonly reported in episodes of care that include J7171 administration?

What diagnoses or clinical scenarios support use of J7171?

Which payers are noted as relevant for coverage of J7171 and does the page provide reimbursement rates?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS code J7171 represent and where is it typically administered?

What clinical and billing documentation elements are recommended when reporting J7171?

Which CPT codes are commonly reported in episodes of care that include J7171 administration?

What diagnoses or clinical scenarios support use of J7171?

Which payers are noted as relevant for coverage of J7171 and does the page provide reimbursement rates?

References