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    v1.0.28
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j3471-hyaluronidase-ovine-preservative-free-injection
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    HCPCS Level II J3471: Hyaluronidase, Ovine Injection, Per USP Unit

    HCPCS Level II code J3471 describes an injection of hyaluronidase, ovine, preservative free, billed per 1 USP unit (up to 999 USP units); this is a pharmacologic enzyme injection typically administered via intramuscular or subcutaneous injection or as an adjunct to facilitate dispersion of other injected drugs, with the typical site of service being outpatient infusion or clinic-based injection settings.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Antibody-Drug Conjugates.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult undergoing ophthalmic or subcutaneous procedures where dispersion of injected medication is difficult due to tissue barriers or prior surgical scarring. For example, a 68-year-old patient presenting to an ophthalmology clinic for periocular injection of a corticosteroid for posterior orbital inflammation, or a patient in a surgical clinic requiring infiltration of local anesthetic around dense subcutaneous adhesions prior to a minor skin procedure. The clinical workflow includes consent and medication reconciliation, preparation of preservative-free ovine hyaluronidase reconstituted to the ordered units, verification of the per-unit dosing (J3471 billed per 1 USP unit), administration by the ophthalmologist or surgeon to increase tissue permeability and facilitate spread of concurrently injected agents, post-injection observation for allergic reaction, and documentation of units administered, injection site, lot numbers, and patient response in the medical record. Typical sites of service are outpatient surgical centers, hospital outpatient departments, ophthalmology clinics, and office-based procedure suites.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    67036Pars plana vitrectomy, mechanical; with removal of vitreous opacities (separate procedure)May be performed by ophthalmologists in the same clinical setting; hyaluronidase can be used periocularly to improve diffusion of adjunctive agents during complex retinal procedures.
    67800Repair of blepharoptosis; sutureEyelid procedures where hyaluronidase may be used to enhance local anesthetic spread or manage post-procedural injection issues in periocular tissues.
    12031Repair, complex, finger(s) single; 2.6 cm to 7.5 cmExample of minor surgical repair where hyaluronidase can facilitate local anesthetic infiltration in scarred tissue planes.
    20550Injection(s); single tendon sheath, or ligament, aponeurosis (e.g., plantar "fasciitis")Injections where hyaluronidase may be used adjunctively to improve dispersion of therapeutic agents in tight tendon sheath spaces.
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularCommon accompanying code for administration of the primary therapeutic agent that hyaluronidase is used to facilitate; hyaluronidase (J3471) billed separately per unit.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207R00000XInternal Medicine PhysicianA physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    207P00000XEmergency Medicine PhysicianAn emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    225700000XMassage TherapistAn individual trained in the manipulation of tissues (as by rubbing, stroking, kneading, or tapping) with the hand or an instrument for remedial or hy…
    207SG0205XPh.D. Medical Genetics PhysicianA medical geneticist works in association with a medical specialist, is affiliated with a clinical genetics program and serves as a consultant to medi…
    247100000XRadiologic TechnologistA medical imaging or radiation therapy professional who is appropriately educated and trained to perform medical imaging procedures using ionizing and…
    163WS0121XPlastic Surgery Registered NurseNursing Service Providers · Registered Nurse

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    B95.61Methicillin susceptible Staphylococcus aureus infection as the cause of diseases classified elsewhere
    H00.012Hordeolum externum right lower eyelid
    H00.021Hordeolum internum right upper eyelid
    H02.831Dermatochalasis of right upper eyelid
    H05.012Cellulitis of left orbit
    H05.033Periostitis of bilateral orbits
    H10.9Unspecified conjunctivitis
    H16.221Keratoconjunctivitis sicca, not specified as Sjogren's, right eye
    H18.10Bullous keratopathy, unspecified eye
    H54.7Unspecified visual loss

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    4 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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