Summary & Overview
HCPCS J3415: Injection, Pyridoxine HCl 100 mg
HCPCS Level II code J3415 denotes a 100 mg injectable dose of pyridoxine hydrochloride (vitamin B6). This code is used to bill for administration of a therapeutic injectable formulation of pyridoxine, commonly administered in outpatient clinics, physician offices, and infusion centers. Nationally, accurate coding of drugs like J3415 affects medication coverage determinations, billing clarity, and how payers reimburse for injectable nutrients and adjunct therapies.
Key payers in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of the clinical context for injectable pyridoxine, common sites of service, and which payers typically cover such injections. The publication also summarizes expected benchmarks for coding and billing practice, highlights relevant policy updates affecting drug administration billing, and outlines practical clinical scenarios where J3415 is used.
This article serves clinicians, practice managers, and billing professionals seeking a national perspective on coding and billing for injectable pyridoxine. It emphasizes coding precision, payer considerations, and the clinical settings where J3415 is most relevant. Data not available in the input is indicated where applicable.
Billing Code Overview
HCPCS Level II code J3415 is defined as Injection, pyridoxine hcl, 100 mg. This HCPCS Level II code represents a single-dose injectable formulation of pyridoxine hydrochloride (vitamin B6) supplied in a 100 mg unit.
Service Type: Therapeutic injectable medication
Typical Site of Service: Outpatient clinic, physician office, or infusion center, where injectable medications are administered by clinical staff.
Clinical & Coding Specifications
Clinical Context
A typical patient is an adult with documented pyridoxine (vitamin B6) deficiency or a clinical indication requiring parenteral supplementation, such as severe malabsorption, short bowel syndrome, persistent vomiting, or when oral therapy is not tolerated or reliably absorbed. The patient often presents to an outpatient infusion center, hospital inpatient ward, or emergency department for administration of J3415 (Injection, pyridoxine HCl, 100 mg). The clinical workflow includes verification of physician order, review of allergies and current medications, confirmation of indication and recent laboratory values (for example, low serum pyridoxal 5'-phosphate or clinical signs of neuropathy/seizure in certain metabolic disorders), preparation of the 100 mg vial/dose by pharmacy or medication technician, and administration via intramuscular or intravenous route per facility protocol. Vital signs are obtained before and after administration; documentation includes dose, route, lot number, expiration, and any immediate adverse reaction. Billing uses HCPCS code J3415 with an applicable modifier if required for the encounter type, payer rules, or unusual circumstances (for example, professional component, discontinued service, or multiple payer conditions).
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
00 | No modifier — standard reporting |