HCPCS J3385: Injection, velaglucerase alfa, 100 units

HCPCS Level II code J3385 describes an injectable biologic, velaglucerase alfa, supplied in 100-unit increments for enzyme replacement therapy; the service is an infusion/injection medication administration typically provided in hospital outpatient infusion centers, specialty infusion clinics, or physician office settings for treatment of conditions requiring glucocerebrosidase replacement.

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HCPCS J3385: Injection, velaglucerase alfa, 100 units

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Get alerted when payer policies referencing J3385 are released or updated.

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Clinical & Coding Specifications

Clinical Context

A 34-year-old adult with Gaucher disease type 1 presents to an outpatient infusion center for enzyme replacement therapy. The patient has a documented prescription for velaglucerase alfa dosed in units and arrives for a scheduled intravenous infusion every two weeks. Pre-infusion nursing assessment includes vital signs, review of prior infusion reactions, current weight for dose verification, and confirmation of any premedication orders (e.g., antihistamine, acetaminophen) if prior infusion reactions occurred. Pharmacy verifies the J3385 vial count required to meet the ordered dose and performs aseptic reconstitution and dilution per manufacturer guidelines. During infusion, nursing documents infusion start and stop times, any adverse reactions, and any modifier-applicable circumstances (for example, use of separate billing for drug wastage with modifier JW if wasted drug is discarded). Post-infusion the patient is observed for an appropriate period, discharged with appointment for the next infusion, and clinical documentation includes drug name velaglucerase alfa, total units administered, lot number, expiration date, route (intravenous), and site of service (typically outpatient infusion center or hospital outpatient department).

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96413`	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug	Used for billing the infusion administration time when velaglucerase alfa infusion duration fits the time-based chemotherapy/biologic infusion coding rules.
`96415`	Each additional hour (chemotherapy administration)	Used when infusion of velaglucerase alfa extends beyond the initial hour and additional time-based units are billed.
`90791`	Psychiatric diagnostic evaluation (placeholder for non-related behavioral health)	Data not typically related; included only when behavioral health evaluation coincides with infusion visit (not standard for this therapy).
`96365`	Intravenous infusion, therapeutic, prophylactic, or diagnostic; initial, up to 1 hour	Alternative infusion administration code sometimes used in non-oncology infusion centers for biologic drug administration when payer allows.
`96376`	Injection, therapeutic, prophylactic or diagnostic, intravenous push, single or initial substance/drug	Used if a portion of therapy requires IV push medication during the infusion visit (e.g., premedication), documented separately.

Related Modifiers

5 rows

Modifier	Description	When to Use
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
2080P0206X	Pediatric Gastroenterology Physician	A pediatrician who specializes in the diagnosis and treatment of diseases of the digestive systems of infants, children and adolescents. This speciali…
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
363L00000X	Nurse Practitioner	(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
261QS1200X	Sleep Disorder Diagnostic Clinic/Center	Ambulatory Health Care Facilities · Clinic/Center
251X00000X	Supports Brokerage Agency	A provider of service/function that assists participating individuals to make informed decisions about what will work best for them is consistent with…
2086H0002X	Hospice and Palliative Medicine (Surgery) Physician	A surgeon with special knowledge and skills to prevent and relieve the suffering experienced by patients with life-limiting illnesses. This specialist…
261QX0203X	Radiation Oncology Clinic/Center	Ambulatory Health Care Facilities · Clinic/Center

Related ICD-10-CM Codes

26 rows

ICD-10-CM Code	Description
C90.00	Multiple myeloma not having achieved remission
C92.00	Acute myeloblastic leukemia, not having achieved remission
D56.9	Thalassemia, unspecified
D57.1	Sickle-cell disease without crisis
D64.9	Anemia, unspecified
D69.6	Thrombocytopenia, unspecified
E75.21	Fabry (-Anderson) disease
E75.22	Gaucher disease
E75.23	Krabbe disease
E75.29	Other sphingolipidosis

Showing 1–10 of 26

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96413`	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug	Used for billing the infusion administration time when velaglucerase alfa infusion duration fits the time-based chemotherapy/biologic infusion coding rules.
`96415`	Each additional hour (chemotherapy administration)	Used when infusion of velaglucerase alfa extends beyond the initial hour and additional time-based units are billed.
`90791`	Psychiatric diagnostic evaluation (placeholder for non-related behavioral health)	Data not typically related; included only when behavioral health evaluation coincides with infusion visit (not standard for this therapy).
`96365`	Intravenous infusion, therapeutic, prophylactic, or diagnostic; initial, up to 1 hour	Alternative infusion administration code sometimes used in non-oncology infusion centers for biologic drug administration when payer allows.
`96376`	Injection, therapeutic, prophylactic or diagnostic, intravenous push, single or initial substance/drug	Used if a portion of therapy requires IV push medication during the infusion visit (e.g., premedication), documented separately.

Related Modifiers

5 rows

Modifier	Description	When to Use
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
2080P0206X	Pediatric Gastroenterology Physician	A pediatrician who specializes in the diagnosis and treatment of diseases of the digestive systems of infants, children and adolescents. This speciali…
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
363L00000X	Nurse Practitioner	(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
261QS1200X	Sleep Disorder Diagnostic Clinic/Center	Ambulatory Health Care Facilities · Clinic/Center
251X00000X	Supports Brokerage Agency	A provider of service/function that assists participating individuals to make informed decisions about what will work best for them is consistent with…
2086H0002X	Hospice and Palliative Medicine (Surgery) Physician	A surgeon with special knowledge and skills to prevent and relieve the suffering experienced by patients with life-limiting illnesses. This specialist…
261QX0203X	Radiation Oncology Clinic/Center	Ambulatory Health Care Facilities · Clinic/Center

Related ICD-10-CM Codes

26 rows

ICD-10-CM Code	Description
C90.00	Multiple myeloma not having achieved remission
C92.00	Acute myeloblastic leukemia, not having achieved remission
D56.9	Thalassemia, unspecified
D57.1	Sickle-cell disease without crisis
D64.9	Anemia, unspecified
D69.6	Thrombocytopenia, unspecified
E75.21	Fabry (-Anderson) disease
E75.22	Gaucher disease
E75.23	Krabbe disease
E75.29	Other sphingolipidosis

Showing 1–10 of 26

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

HCPCS J3385: Injection, velaglucerase alfa, 100 units

Sign up for hcpcs J3385 policy alerts

HCPCS J3385: Injection, velaglucerase alfa, 100 units

Sign up for hcpcs J3385 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS code J3385 represent and where is it typically administered?

Which HCPCS modifiers are commonly used with J3385 and when should they be applied?

How should infusion administration be billed in relation to J3385?

What diagnoses commonly support medical necessity for J3385?

What clinical and documentation steps are highlighted for a J3385 infusion visit?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS code J3385 represent and where is it typically administered?

Which HCPCS modifiers are commonly used with J3385 and when should they be applied?

How should infusion administration be billed in relation to J3385?

What diagnoses commonly support medical necessity for J3385?

What clinical and documentation steps are highlighted for a J3385 infusion visit?

References