HCPCS Level II J3299: Triamcinolone Acetonide (XIPERE) Injection, 1 mg

HCPCS Level II code J3299 describes an injection of triamcinolone acetonide (XIPERE), 1 mg, used for intravitreal administration to treat ocular conditions; the service is an injectable medication typically provided in an ophthalmology clinic or ambulatory surgical center for intraocular therapy.

For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Antibody-Drug Conjugates, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only).

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HCPCS Level II J3299: Triamcinolone Acetonide (XIPERE) Injection, 1 mg

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Get alerted when payer policies referencing J3299 are released or updated.

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Clinical & Coding Specifications

Clinical Context

A typical adult patient presents to an ophthalmology clinic with symptomatic macular edema related to branch retinal vein occlusion. The patient reports decreased central vision and metamorphopsia over several weeks. After clinical examination, optical coherence tomography confirms cystoid macular edema with fluid involving the fovea. The treating retinal specialist determines that an intravitreal sustained‑release triamcinolone acetonide implant (J3299 — triamcinolone acetonide (XIPERE), 1 mg) is appropriate. The clinic obtains informed consent, documents indication, and screens for contraindications (active ocular infection, uncontrolled glaucoma). On the day of service, the patient is prepped in a procedure room or minor procedure suite within the ophthalmology clinic or ambulatory surgery center. Topical anesthetic and povidone‑iodine antisepsis are applied; sterile technique and eyelid speculum are used. The implant is injected intravitreally using manufacturer instructions. The provider documents lot number and quantity administered, any procedural difficulty, and observed immediate complications. Post‑procedure instructions are provided, intraocular pressure is measured before discharge, and a follow‑up visit is scheduled to monitor efficacy and intraocular pressure. Billing uses HCPCS Level II code J3299 for the drug; associated evaluation and management, injection, or imaging services are billed separately per payer rules.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`67028`	Intravitreal injection of a pharmacologic agent (separate procedure)	Commonly billed for the injection procedure when the drug is administered intravitreally; billed in addition to the drug HCPCS `J3299` when payer policy allows.
`92250`	Fundus photography with interpretation and report	Performed before or after implantation to document retinal status and response to therapy.
`92134`	Scanning computerized ophthalmic diagnostic imaging, posterior segment, with interpretation and report; unilateral or bilateral	Optical coherence tomography is commonly performed to quantify macular edema and monitor treatment effect.
`99213`	Office or other outpatient visit for the evaluation and management of an established patient, low to moderate complexity	Typical pre‑ or post‑injection follow‑up visit billed separately from the drug and injection procedure.
`67015`	Destruction of localized lesion of retina (cryo or photocoagulation)	May be performed before or after drug therapy for concomitant retinal pathology; included as an example of related retinal procedures.

Related Modifiers

5 rows

Modifier	Description	When to Use
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
82	Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…	- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207ZP0105X	Clinical Pathology/Laboratory Medicine Physician	A pathologist deals with the causes and nature of disease and contributes to diagnosis, prognosis and treatment through knowledge gained by the labora…
207R00000X	Internal Medicine Physician	A physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
363LF0000X	Family Nurse Practitioner	Physician Assistants & Advanced Practice Nursing Providers · Nurse Practitioner
2278P1006X	Pulmonary Function Technologist Certified Respiratory Therapist	An individual who is trained and qualified to perform pulmonary diagnostic tests. In the course of conducting these tests, the Pulmonary Function Tec…
332BN1400X	Nursing Facility Supplies (DME)	Suppliers · Durable Medical Equipment & Medical Supplies
156FX1201X	Optometric Assistant Technician	An optometric assistant assists optometrists by performing duties, including but not limited to, customer service, basic eye testing, and patient educ…
1041S0200X	School Social Worker	Behavioral Health & Social Service Providers · Social Worker
367A00000X	Advanced Practice Midwife	Advanced practice midwifery encompasses the independent provision of care during pregnancy, childbirth, and the postpartum period; sexual and reproduc…

Related Payer Policy Updates

Specialty: Hematology/Oncology1 / 3

10 rows

Policy	Payer	Effective Date
Epithelial Cell Cytology in Breast Cancer Risk Assessment	Oscar Health	2026-10-01
Antibody-Drug Conjugates	Premera Bluecross	2026-08-01
Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)	UnitedHealthcare	2026-08-01
Chimeric Antigen Receptor (CAR) T-Cell Therapy	Colorado Rocky Mountain Health Plans	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)	UnitedHealthcare	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for Idaho Only)	UnitedHealthcare	2026-08-01
Allogeneic Hematopoietic Progenitor Cell Therapy	Ambetter Georgia	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for New Jersey Only)	UnitedHealthcare	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for Ohio Only)	UnitedHealthcare	2026-08-01
Intraperitoneal Chemotherapy (HIPEC/IPHC and PIPAC)	priority health	2026-08-01

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`67028`	Intravitreal injection of a pharmacologic agent (separate procedure)	Commonly billed for the injection procedure when the drug is administered intravitreally; billed in addition to the drug HCPCS `J3299` when payer policy allows.
`92250`	Fundus photography with interpretation and report	Performed before or after implantation to document retinal status and response to therapy.
`92134`	Scanning computerized ophthalmic diagnostic imaging, posterior segment, with interpretation and report; unilateral or bilateral	Optical coherence tomography is commonly performed to quantify macular edema and monitor treatment effect.
`99213`	Office or other outpatient visit for the evaluation and management of an established patient, low to moderate complexity	Typical pre‑ or post‑injection follow‑up visit billed separately from the drug and injection procedure.
`67015`	Destruction of localized lesion of retina (cryo or photocoagulation)	May be performed before or after drug therapy for concomitant retinal pathology; included as an example of related retinal procedures.

Related Modifiers

5 rows

Modifier	Description	When to Use
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
82	Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…	- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207ZP0105X	Clinical Pathology/Laboratory Medicine Physician	A pathologist deals with the causes and nature of disease and contributes to diagnosis, prognosis and treatment through knowledge gained by the labora…
207R00000X	Internal Medicine Physician	A physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
363LF0000X	Family Nurse Practitioner	Physician Assistants & Advanced Practice Nursing Providers · Nurse Practitioner
2278P1006X	Pulmonary Function Technologist Certified Respiratory Therapist	An individual who is trained and qualified to perform pulmonary diagnostic tests. In the course of conducting these tests, the Pulmonary Function Tec…
332BN1400X	Nursing Facility Supplies (DME)	Suppliers · Durable Medical Equipment & Medical Supplies
156FX1201X	Optometric Assistant Technician	An optometric assistant assists optometrists by performing duties, including but not limited to, customer service, basic eye testing, and patient educ…
1041S0200X	School Social Worker	Behavioral Health & Social Service Providers · Social Worker
367A00000X	Advanced Practice Midwife	Advanced practice midwifery encompasses the independent provision of care during pregnancy, childbirth, and the postpartum period; sexual and reproduc…

Related Payer Policy Updates

Specialty: Hematology/Oncology1 / 3

10 rows

Policy	Payer	Effective Date
Epithelial Cell Cytology in Breast Cancer Risk Assessment	Oscar Health	2026-10-01
Antibody-Drug Conjugates	Premera Bluecross	2026-08-01
Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)	UnitedHealthcare	2026-08-01
Chimeric Antigen Receptor (CAR) T-Cell Therapy	Colorado Rocky Mountain Health Plans	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)	UnitedHealthcare	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for Idaho Only)	UnitedHealthcare	2026-08-01
Allogeneic Hematopoietic Progenitor Cell Therapy	Ambetter Georgia	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for New Jersey Only)	UnitedHealthcare	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for Ohio Only)	UnitedHealthcare	2026-08-01
Intraperitoneal Chemotherapy (HIPEC/IPHC and PIPAC)	priority health	2026-08-01

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

HCPCS Level II J3299: Triamcinolone Acetonide (XIPERE) Injection, 1 mg

Sign up for hcpcs J3299 policy alerts

HCPCS Level II J3299: Triamcinolone Acetonide (XIPERE) Injection, 1 mg

Sign up for hcpcs J3299 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Payer Policy Updates

Related Codes

What does HCPCS code J3299 describe and how is it used in billing?

Which CPT codes are commonly billed alongside J3299?

Which modifiers are applicable to J3299 billing and when are they used?

What clinical scenario and documentation accompany use of J3299?

Which payers are mentioned and are there common policy themes for coverage?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Payer Policy Updates

Related Codes

What does HCPCS code J3299 describe and how is it used in billing?

Which CPT codes are commonly billed alongside J3299?

Which modifiers are applicable to J3299 billing and when are they used?

What clinical scenario and documentation accompany use of J3299?

Which payers are mentioned and are there common policy themes for coverage?

References