J2788 Rho(D) Immune Globulin | HCPCS Reimbursement | OpenPayer

Summary & Overview

HCPCS Level II J2788: Rho(D) Immune Globulin Minidose Injection

HCPCS Level II code J2788 denotes a minidose injection of Rho(D) immune globulin, human — 50 micrograms (250 international units) — used to prevent Rh sensitization after exposure to Rh-positive blood. Nationally, this code is important for obstetric and post-exposure prophylaxis workflows and for appropriate billing of a commonly administered immunoglobulin product. Key payers addressed in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare.

Readers will find a concise overview of clinical context, typical sites of service, and billing considerations tied to J2788. The publication provides benchmark information on coverage patterns and reimbursement groupings, highlights any recent policy updates relevant to Rho(D) immune globulin administration, and clarifies coding nuances for the minidose product. The report is intended for revenue cycle managers, billing professionals, and clinical leaders seeking a national perspective on handling claims for Rho(D) immune globulin minidose injections.

AetnaBlue Cross Blue ShieldCigna HealthUnitedHealthcareMedicareJ2788HCPCS Level IIRho(D) immune globulinimmunoglobulin injectionobstetricsprophylaxisoutpatientbilling

Billing Code Overview

HCPCS Level II code J2788 describes an injection of Rho(D) immune globulin, human, minidose, 50 micrograms (250 i.u.). This medication is an immunoglobulin preparation given to prevent Rh isoimmunization in Rh-negative individuals exposed to Rh-positive blood.

Service type: Therapeutic prophylactic injection
Typical site of service: Outpatient clinic, obstetrics/gynecology office, or infusion center

Clinical & Coding Specifications

Clinical Context

A typical patient receiving J2788 is an Rh-negative person requiring Rh immune globulin prophylaxis in settings with potential exposure to Rh(D) positive fetal or neonatal red blood cells. Common scenarios include a non-sensitized pregnant person after delivery of an Rh-positive infant, after certain obstetric events (e.g., spontaneous or induced abortion, ectopic pregnancy, amniocentesis, external cephalic version), or after a transfusion-related exposure. The clinical workflow: confirmation of maternal Rh-negative status and paternal or neonatal Rh(D) positive status (when available); verification of patient history for prior sensitization (antibody screen); calculation of appropriate dose (minidose J2788 = 50 micrograms / 250 IU for limited exposures); informed consent and allergy check; preparation of medication in the clinic, labor and delivery unit, or outpatient infusion/office setting; administration via intramuscular injection; documentation of lot number, expiration, injection site, and patient response; post-administration observation for immediate adverse reaction per facility protocol; and updating the maternal chart and immunization/administration records. Typical site of service: outpatient clinic, labor and delivery unit, postpartum recovery, or physician office. Typical patient: an Rh-negative pregnant person postpartum after delivery of an Rh-positive neonate requiring routine mini-dose Rh immune globulin prophylaxis to prevent alloimmunization.

Coding Specifications

Modifier	Description	When to Use

HCPCS Level II J0800: Corticotropin Injection, up to 40 Units

HCPCS-J8501-APREPITANT-ORAL-5MG-ANTIEMETIC

HCPCS Level II J8501: Aprepitant, Oral, 5 mg

HCPCS-J0574-BUPRENORPHINE-NALOXONE-7-TO-10MG-ORAL

HCPCS J0574: Buprenorphine/Naloxone Oral, >6 mg to ≤10 mg Buprenorphine

HCPCS-J0577-BUPRENORPHINE-EXTENDED-RELEASE-SHORT-COURSE-INJECTION

HCPCS J0577: Buprenorphine Extended-Release Injection, Short Course

HCPCS-J3355-UROFOLLITROPIN-75-IU-INJECTION

HCPCS Level II J3355: Urofollitropin Injection, 75 IU

HCPCS-J7329-HYALURONAN-TRIVISC-INTRA-ARTICULAR-INJECTION-1MG

HCPCS J7329: Hyaluronan (Trivisc) Intra-articular Injection, 1 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS J0134: Injection, Acetaminophen (Fresenius Kabi), 10 mg

HCPCS-J2355-OPRELVEKIN-INJECTION-5MG

HCPCS J2355: Oprelvekin Injection, 5 mg

HCPCS-J3570-LAETRILE-AMYGDALIN-VITAMIN-B17

HCPCS Level II J3570: Laetrile (amygdalin, vitamin B17)

HCPCS-J2599-VASOPRESSIN-INJECTION-AMERICAN-REGENT

HCPCS J2599: Vasopressin Injection (American Regent), 1 Unit

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Taxonomy Code	Specialty	Notes
`207Q00000X`	Obstetrics & Gynecology	Obstetricians frequently order and administer Rh immune globulin in delivery and postpartum settings
`207R00000X`	Maternal & Fetal Medicine	MFM specialists manage high-risk pregnancies and perform procedures with potential fetal-maternal hemorrhage risk
`163W00000X`	Family Medicine	Family physicians provide prenatal and postpartum care and may administer `J2788` in office settings
`3336D0003X`	Diagnostic Radiology	Radiologists may be involved when procedures (e.g., amniocentesis) that trigger prophylaxis are performed;
`363LF0000X`	Infusion Therapy	Infusion or procedural nurses administer intramuscular immunoglobulin in outpatient infusion centers

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`O36.0130`	Maternal care for isoimmunization, first trimester, unspecified fetus and fetus number	Represents maternal Rh alloimmunization surveillance where prophylaxis decisions are relevant
`O36.0131`	Maternal care for isoimmunization, first trimester, fetus 1	Relevant when early pregnancy events prompt consideration of Rh immune globulin
`O36.1130`	Maternal care for isoimmunization, second trimester, unspecified fetus and fetus number	Relevant for mid-trimester events with potential fetomaternal hemorrhage
`O36.2130`	Maternal care for isoimmunization, third trimester, unspecified fetus and fetus number	Applies when third-trimester events or procedures raise need for Rh prophylaxis
`O36.3930`	Maternal care for other specified fetal problems, unspecified trimester, unspecified fetus	Used in contexts of fetal testing or procedures where prophylaxis may be indicated

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`90460`	Immunization administration through 18 years of age via any route of administration, with counseling by a physician or other qualified health care professional; first or only component of each vaccine or toxoid administered	Used when counseling and administration of an immune product like Rh immune globulin is separately billed in settings that permit administration codes (billing guidance varies by payer)
`90461`	Immunization administration through 18 years of age via any route of administration, with counseling by a physician or other qualified health care professional; each additional component	Use when multiple immunologic agents are administered during the same encounter and separate administration units are billed
`36591`	Collection of blood from a catheter, with syringe or tube, without infusion or transfusion, for blood sample (e.g., for type and screen)	Performed when obtaining maternal blood for type and antibody screen prior to administration
`36415`	Collection of venous blood by venipuncture	Commonly performed to obtain maternal type and screen or antibody testing related to administration decisions
`58150`	Total abdominal hysterectomy, but sterilization codes are context-specific; provided here as an example of obstetric/gynecologic procedures	Listed only as an example of concurrent obstetric/gynecologic procedures where Rh immune globulin administration may be required post-procedure

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