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    v1.0.28
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j2785-regadenoson-injection-0-1-mg-pharmacologic-stress-agent
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    HCPCS Level II J2785: Regadenoson 0.1 mg Injection

    HCPCS Level II code J2785 represents an injection of regadenoson 0.1 mg, a single-dose pharmacologic stress agent used during pharmacologic myocardial perfusion imaging; the service is drug administration for cardiac stress testing and is typically provided in hospital outpatient departments, imaging centers, and ambulatory care settings.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only).

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    Clinical & Coding Specifications

    Clinical Context

    A 64-year-old patient with known coronary artery disease and baseline exertional dyspnea is referred for pharmacologic myocardial perfusion imaging because they are unable to achieve adequate exercise stress due to limited mobility and knee osteoarthritis. The nuclear medicine team verifies indications and allergies, obtains informed consent, and places IV access. Baseline vital signs and electrocardiographic monitoring are recorded. The patient receives a single intravenous bolus of J2785 (regadenoson, 0.1 mg) as a vasodilator stress agent while the nuclear medicine technologist prepares the radiotracer. Heart rate, blood pressure, and ECG are monitored continuously; symptomatic side effects such as flushing, chest discomfort, or dyspnea are assessed and managed per protocol. After the appropriate interval following regadenoson administration, the technologist injects the myocardial perfusion radiotracer and acquires stress images. Recovery and post-procedure monitoring continue until hemodynamically stable, then results are reviewed by the interpreting cardiologist or nuclear medicine physician and documented in the medical record. Typical sites of service include outpatient imaging centers, hospital outpatient departments, and ambulatory surgical centers where pharmacologic stress testing and nuclear cardiology studies are performed.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    78452Myocardial perfusion imaging, tomographic (SPECT), multiple studies, stress and rest, including attenuation correction when performed; single day imaging protocolCommonly paired with J2785 when regadenoson is used as the pharmacologic stress agent for SPECT perfusion imaging; regadenoson is administered before injection of radiotracer for the stress portion.
    78451Myocardial perfusion imaging, tomographic (SPECT), multiple studies, stress onlyUsed when only the stress portion is performed (e.g., when prior rest images are available); J2785 is administered for the stress acquisition.
    93015Cardiovascular stress test using maximal or submaximal treadmill or bicycle exercise, continuous ECG monitoring, with supervision, interpretation and reportWhen exercise testing is attempted but pharmacologic stress with J2785 is used because exercise was inadequate; documents the stress test interpretation component.
    93010Electrocardiogram, routine ECG with interpretation and reportPerformed before and during pharmacologic stress to monitor rhythm and ischemic changes concurrent with J2785 administration.
    96372Therapeutic, prophylactic, or diagnostic injection (subcutaneous or intramuscular)Sometimes used for reporting injection administration services in settings where payor policies require- however, J2785 is the HCPCS code reporting the drug itself and typically supersedes separate injection CPT billing.

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207R00000XInternal Medicine PhysicianA physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
    261QU0200XUrgent Care Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    2084P0800XPsychiatry PhysicianA Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    364SP1700XPerinatal Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
    2084N0402XNeurology with Special Qualifications in Child Neurology PhysicianA Child Neurologist specializes in neurology with special skills in diagnosis and treatment of neurologic disorders of the neonatal period, infancy, e…
    225700000XMassage TherapistAn individual trained in the manipulation of tissues (as by rubbing, stroking, kneading, or tapping) with the hand or an instrument for remedial or hy…
    1223X2210XOrofacial Pain DentistryA dentist who assesses, diagnoses, and treats patients with complex chronic orofacial pain and dysfunction disorders, oromotor and jaw behavior disord…

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    E11.9Type 2 diabetes mellitus without complications
    E78.5Hyperlipidemia, unspecified
    I05.9Rheumatic mitral valve disease, unspecified
    I20.0Unstable angina
    I20.1Angina pectoris with documented spasm
    I20.9Angina pectoris, unspecified
    I21.3ST elevation (STEMI) myocardial infarction of unspecified site
    I21.4Non-ST elevation (NSTEMI) myocardial infarction
    I25.10Atherosclerotic heart disease of native coronary artery without angina pectoris
    I25.110Atherosclerotic heart disease of native coronary artery with unstable angina pectoris

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Chimeric Antigen Receptor (CAR) T-Cell TherapyColorado Rocky Mountain Health Plans2026-08-01
    Allogeneic Hematopoietic Progenitor Cell TherapyAmbetter Georgia2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Idaho Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for New Jersey Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Ohio Only)UnitedHealthcare2026-08-01
    Reblozyl (luspatercept-aamt) Medical Benefit Drug PolicyUnitedHealthcare2026-08-01

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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